Evidence map›Paper›PMID 27207166›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2016

Purinergic signaling triggers endfoot high-amplitude Ca2+ signals and causes inversion of neurovascular coupling after subarachnoid hemorrhage.

Anthony C Pappas, Masayo Koide, George C Wellman

Open access · bronzeAbstract read
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Long-acting statin for aneurysmal subarachnoid hemorrhage: A randomized, double-blind, placebo-controlled trial.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2018
    Trial
  2. Review
  3. Review
  4. Astrocyte Regulation of Cerebral Blood Flow in Health and Disease.Cold Spring Harbor perspectives in biology · 2024
    Review
  5. Review
  6. Article
  7. Article
  8. The yin and yang of KMicrocirculation (New York, N.Y. : 1994) · 2018
    Review
  9. Inversion of neurovascular coupling after subarachnoid hemorrhage in vivo.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Anthony C PappasDepartment of Pharmacology, University of Vermont, Burlington, VT, USA.
Masayo KoideDepartment of Pharmacology, University of Vermont, Burlington, VT, USA.
George C WellmanDepartment of Pharmacology, University of Vermont, Burlington, VT, USA George.Wellman@uvm.edu.
University of Vermont · US

Funding

Impact of SAH on Parenchymal Arterioles and Neurovascular CouplingP01HL095488 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI BONEV, ADRIAN · 2010 to 2014
$11.4M
Center for Neuroscience ExcellenceP30GM103498 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI PARSONS, RODNEY L · 2012 to 2015
$4.3M
CENTER FOR NEUROSCIENCE EXCELLENCEP30RR032135 · NCRR · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI PARSONS, RODNEY L · 2011 to 2011
$1.1M
Acquisition of a Zeiss LSM 7 MP multiphoton microscopeS10OD010583 · OD · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI PARSONS, RODNEY L · 2012 to 2012
$599k
NCRR NIH HHS P30 RR032135NHLBI NIH HHS P01 HL095488NIGMS NIH HHS P30 GM103498NIH HHS S10 OD010583
6 · The paper itself

Abstract

Neurovascular coupling supports brain metabolism by matching focal increases in neuronal activity with local arteriolar dilation. Previously, we demonstrated that an emergence of spontaneous endfoot high-amplitude Ca

Indexed as

AnimalsAstrocytesCalcium SignalingDisease Models, AnimalMaleMicrocirculationMicroscopy, Fluorescence, MultiphotonNeurovascular CouplingPurinergic P2Y Receptor AntagonistsRats, Sprague-DawleyReceptors, Purinergic P2YSignal TransductionSubarachnoid HemorrhageSuraminVasodilationPurinergic P2Y Receptor AntagonistsReceptors, Purinergic P2YSuraminastrocyte Ca2+ signalingastrocyte endfeetneurovascular couplingpurinergic receptorsSubarachnoid hemorrhage

Identifiers

PMID27207166
PMCPMC5094310
OpenAlexW2403554986

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.