ArticleJournal of biomedical optics2016
In vivo photoacoustic microscopy of human cuticle microvasculature with single-cell resolution.
Article in Journal of biomedical optics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- Article
- Ultrasound-Based Techniques for Visualization of Dermal Microvasculature: A Scoping Review.Diagnostics (Basel, Switzerland) · 2026Review
- Optical histopathology based on the nonlabeling analysis with multiphoton excitation imaging.Pathology international · 2025Review
- Nailfold Video-Capillaroscopy in Sarcoidosis: New Perspectives and Challenges.Tomography (Ann Arbor, Mich.) · 2024Review
- Article
- Application of photoacoustic computed tomography in biomedical imaging: A literature review.Bioengineering & translational medicine · 2023Review
- Photoacoustic imaging for microcirculation.Microcirculation (New York, N.Y. : 1994) · 2022Review
- Tissue-mimicking phantoms for performance evaluation of photoacoustic microscopy systems.Biomedical optics express · 2022Article
- Probing single-cell oxygen reserve in sickled erythrocytes via in vivo photoacoustic microscopy.American journal of hematology · 2022Article
- Seeing through the Skin: Photoacoustic Tomography of Skin Vasculature and Beyond.JID innovations : skin science from molecules to population health · 2021Review
- High-resolution functional photoacoustic monitoring of vascular dynamics in human fingers.Photoacoustics · 2021Article
- Photoacoustic Tomography Opening New Paradigms in Biomedical Imaging.Advances in experimental medicine and biology · 2021Article
- NIH Workshop 2018: Towards Minimally Invasive or Noninvasive Approaches to Assess Tissue Oxygenation Pre- and Post-transfusion.Transfusion medicine reviews · 2021Review
- Photothermal therapy and photoacoustic imaging via nanotheranostics in fighting cancer.Chemical Society reviews · 2019Review
- Dual-axis illumination for virtually augmenting the detection view of optical-resolution photoacoustic microscopy.Journal of biomedical optics · 2018Article
- Repeatability of vessel density measurement in human skin by OCT-based microangiography.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2017Article
- Handheld Photoacoustic Microscopy Probe.Scientific reports · 2017Article
- Non-labeling multiphoton excitation microscopy as a novel diagnostic tool for discriminating normal tissue and colorectal cancer lesions.Scientific reports · 2017Article
- Advanced optoacoustic methods for multiscale imaging of in vivo dynamics.Chemical Society reviews · 2017Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
As a window on the microcirculation, human cuticle capillaries provide rich information about the microvasculature, such as its morphology, density, dimensions, or even blood flow speed. Many imaging technologies have been employed to image human cuticle microvasculature. However, almost none of these techniques can noninvasively observe the process of oxygen release from single red blood cells (RBCs), an observation which can be used to study healthy tissue functionalities or to diagnose, stage, or monitor diseases. For the first time, we adapted single-cell resolution photoacoustic (PA) microscopy (PA flowoxigraphy) to image cuticle capillaries and quantified multiple functional parameters. Our results show more oxygen release in the curved cuticle tip region than in other regions of a cuticle capillary loop, associated with a low of RBC flow speed in the tip region. Further analysis suggests that in addition to the RBC flow speed, other factors, such as the drop of the partial oxygen pressure in the tip region, drive RBCs to release more oxygen in the tip region.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.