ArticleBMC neuroscience2016
Increased hypothalamic serotonin turnover in inflammation-induced anorexia.
Article in BMC neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- The Effects of Pro-, Pre-, and Synbiotics on Muscle Wasting, a Systematic Review-Gut Permeability as Potential Treatment Target.Nutrients · 2021Pooled it
- Delta-9-tetrahydrocannabinol ameliorates oxidative stress, mitochondrial redox state, and neuroinflammation induced by high-fructose diet.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Emerging roles of OSM and EDA2R-NIK signalling in cancer-associated muscle wasting.Journal of muscle research and cell motility · 2026Review
- Cytokines and adolescent anorexia nervosa: a case-control study.BMC psychiatry · 2026Article
- Comprehensive insights into emerging advances in the Neurobiology of anorexia.Journal of advanced research · 2026Review
- Mechanisms and pharmacotherapy of cancer cachexia-associated anorexia.Pharmacology research & perspectives · 2025Review
- Role of the sympathetic nervous system in cancer-associated cachexia and tumor progression in tumor-bearing BALB/c mice.BMC neuroscience · 2024Article
- Current Therapeutic Targets in Cancer Cachexia: A Pathophysiologic Approach.American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting · 2023Review
- Lipopolysaccharide-induced hypothalamic inflammation in cancer cachexia-anorexia is amplified by tumour-derived prostaglandin E2.Journal of cachexia, sarcopenia and muscle · 2022Article
- Effects of early-life cecal microbiota transplantation from divergently selected inbred chicken lines on growth, gut serotonin, and immune parameters in recipient chickens.Poultry science · 2022Article
- Hypothalamic inflammation in metabolic disorders and aging.Cellular and molecular life sciences : CMLS · 2021Review
- Interleukin-6: Molecule in the Intersection of Cancer, Ageing and COVID-19.International journal of molecular sciences · 2020Review
- Cutaneous melanoma dissemination is dependent on the malignant cell properties and factors of intercellular crosstalk in the cancer microenvironment (Review).International journal of oncology · 2020Review
- Cancer cachexia and its pathophysiology: links with sarcopenia, anorexia and asthenia.Journal of cachexia, sarcopenia and muscle · 2020Review
- Molecular Basis for the Therapeutic Effects of Exercise on Mitochondrial Defects.Frontiers in physiology · 2020Review
- Time-Dependent Effects of Acute Handling on the Brain Monoamine System of the SalmonidFrontiers in neuroscience · 2020Article
- Inter-tissue communication in cancer cachexia.Nature reviews. Endocrinology · 2018Review
- Involvement of dopamine, but not norepinephrine, in the sex-specific regulation of juvenile socially rewarding behavior by vasopressin.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- Thymulin, free or bound to PBCA nanoparticles, protects mice against chronic septic inflammation.PloS one · 2018Article
- Hypothalamic Inflammation and Energy Balance Disruptions: Spotlight on Chemokines.Frontiers in endocrinology · 2017Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAnorexia can occur as a serious complication of disease. Increasing evidence suggests that inflammation plays a major role, along with a hypothalamic dysregulation characterized by locally elevated serotonin levels. The present study was undertaken to further explore the connections between peripheral inflammation, anorexia and hypothalamic serotonin metabolism and signaling pathways. First, we investigated the response of two hypothalamic neuronal cell lines to TNFα, IL-6 and LPS. Next, we studied transcriptomic changes and serotonergic activity in the hypothalamus of mice after intraperitoneal injection with TNFα, IL-6 or a combination of TNFα and IL-6.
resultsIn vitro, we showed that hypothalamic neurons responded to inflammatory mediators by releasing cytokines. This inflammatory response was associated with an increased serotonin release. Mice injected with TNFα and IL-6 showed decreased food intake, associated with altered expression of inflammation-related genes in the hypothalamus. In addition, hypothalamic serotonin turnover showed to be elevated in treated mice.
conclusionsOverall, our results underline that peripheral inflammation reaches the hypothalamus where it affects hypothalamic serotoninergic metabolism. These hypothalamic changes in serotonin pathways are associated with decreased food intake, providing evidence for a role of serotonin in inflammation-induced anorexia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.