ArticleJournal of autism and developmental disorders2019
Widespread Disrupted White Matter Microstructure in Autism Spectrum Disorders.
Article in Journal of autism and developmental disorders, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The impact of exercise interventions on core symptoms of 3-12-year-old children with autism spectrum disorder: a systematic review and network meta-analysis.European child & adolescent psychiatry · 2025Pooled it
- Disrupted focal white matter integrity in autism spectrum disorder: A voxel-based meta-analysis of diffusion tensor imaging studies.Progress in neuro-psychopharmacology & biological psychiatry · 2018Pooled it
- Sharing Our World: Impact of Group Motor Skill Learning on Joint Attention in Children with Autism Spectrum Disorder.Journal of autism and developmental disorders · 2026Article
- Facial emotion recognition function and white matter microstructural alterations in drug-naive, comorbidity-free autism.European archives of psychiatry and clinical neuroscience · 2025Article
- Mapping along-tract commissural and association white matter microstructural differences in autistic children and young adults.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Exploring the Autistic Brain: A Systematic Review of Diffusion Tensor Imaging Studies on Neural Connectivity in Autism Spectrum Disorder.Brain sciences · 2025Review
- White matter connectivity and social functioning in survivors of pediatric brain tumor.Journal of neuro-oncology · 2024Article
- Interleukin-6 Inhibits Expression of miR-204-5p, a Regulator of Oligodendrocyte Differentiation: Involvement of miR-204-5p in the Prevention of Chemical-Induced Oligodendrocyte Impairment.Molecular neurobiology · 2024Article
- Tract- and gray matter- based spatial statistics show white matter and gray matter microstructural differences in autistic males.Frontiers in neuroscience · 2023Article
- In Vivo Clonal Analysis Reveals Development Heterogeneity of Oligodendrocyte Precursor Cells Derived from Distinct Germinal Zones.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- Associations Between Limbic System White Matter Structure and Socio-Emotional Functioning in Children with ADHD + ASD.Journal of autism and developmental disorders · 2021Article
- Hericium erinaceus mycelium and its small bioactive compounds promote oligodendrocyte maturation with an increase in myelin basic protein.Scientific reports · 2021Article
- Alpha connectivity and inhibitory control in adults with autism spectrum disorder.Molecular autism · 2020Article
- Age-related differences in white matter diffusion measures in autism spectrum condition.Molecular autism · 2020Article
- Differences in White Matter Microstructure Among Children With Developmental Coordination Disorder.JAMA network open · 2020Article
- A diffusion-weighted imaging tract-based spatial statistics study of autism spectrum disorder in preschool-aged children.Journal of neurodevelopmental disorders · 2019Article
- The cingulum and cingulate U-fibers in children and adolescents with autism spectrum disorders.Human brain mapping · 2019Article
- Article
- A quantitative method for microstructural analysis of myelinated axons in the injured rodent brain.Scientific reports · 2017Article
- Heterogeneity in oligodendroglia: Is it relevant to mouse models and human disease?Journal of neuroscience research · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Autism Spectrum Disorders (ASDs) are characterised by impaired social communication and restricted repetitive behaviours. Researchers posit that these core features may be underpinned by disrupted structural connectivity. A tract based spatial statistical analysis of diffusion MRI data was performed to investigate white matter organisation (an indication of structural connectivity) in a well-defined cohort of 45 ASD and 45 age and IQ matched control participants. Aberrant structural connectivity characterised by reduced fractional anisotropy was observed in several fiber pathways in ASD relative to controls. Disrupted white matter organisation was associated with social deficits and restricted repetitive behaviours in ASD. Abnormal structural connectivity is apparent in ASD and may be linked to the core behavioural features of the disorder.
Indexed as
Identifiers
27207090What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.