Evidence map›Paper›PMID 27206921›Full record

ArticleBMC neurology2016

Static posturography across the EDSS scale in people with multiple sclerosis: a cross sectional study.

Alon Kalron, Dalia Nitzani, Anat Achiron

Open access · goldAbstract read
In one paragraph

Article in BMC neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 45 citations in OpenAlex.

  1. Article
  2. PROMs reveal early fall risk in the absence of clinical disability in people with multiple sclerosis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Article
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  5. Gait Kinematics Assessed by ViconSensors (Basel, Switzerland) · 2025
    Observational
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  7. Article
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  10. Postural Control in Relapsing-Remitting Multiple Sclerosis.International archives of otorhinolaryngology · 2022
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  17. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Alon KalronDepartment of Physical Therapy, School of Health Professions, Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel. alkalron@gmail.com.
Dalia NitzaniMultiple Sclerosis Center, Sheba Medical Center, Tel Hashomer, Israel.
Anat AchironMultiple Sclerosis Center, Sheba Medical Center, Tel Hashomer, Israel.
Sheba Medical Center · ILTel Aviv University · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPosturography is considered the gold standard objective measure of standing postural control in people with multiple sclerosis (PwMS). This reliable tool provides quantitative data related to risk of falling and white and gray matter brain damage due to MS. Nevertheless, it remains unclear whether and to what extent, postural control declines throughout the disease process. We therefore examined the impact of disability on posturography measures in PwMS.

methodsIn this cross-sectional study, the data pool was divided into seven levels of disability based on the Expanded Disability Status Scale (EDSS) score. The study group comprised 464 PwMS, mean disease duration was 6.2 (SD = 7.5) years and mean age 42.6 (SD = 14.1). Static postural control parameters were obtained from the Zebris FDM-T instrumented Treadmill (Medical GmbH, Germany).

resultsA significant positive correlation between the EDSS and posturography parameters was found. Scores for the ellipse area, center of pressure (CoP) path length and sway rate with eyes open were Spearman's rho =0.512, 0.527, 0.528; (P-value < 0.001), respectively. Non-significant differences were observed between the EDSS subgroups at the lower end of the spectrum (EDSS 0-2.5) in all posturography parameters. In contrast, MS patients with an EDSS score of 3.0-3.5 demonstrated a significant increase in the ellipse area with eyes open (~108 %) and closed (~169 %), CoP path length with eyes open (~83 %) and closed (~88 %) and sway rate with eyes open (~39 %) and closed (~148 %), compared with those who scored within the range of 0-2.5 in the EDSS. Non-significant differences were observed between MS patients with an EDSS score of 3.0-5.5. MS patients with an EDSS score of 6.0-6.5 were significantly poorer in 4 (out of 6) balance measures compared to other disability subgroups.

conclusionsPosturography CoP trajectories are appropriate outcome measures indicating disability deterioration in PwMS.

Indexed as

AdultAgedCross-Sectional StudiesDisability EvaluationFemaleHumansMaleMiddle AgedMultiple SclerosisPostural BalanceSeverity of Illness IndexYoung AdultBalanceDisabilityEDSSMultiple sclerosisNeurologicalPostural control

Identifiers

PMID27206921
PMCPMC4873986
OpenAlexW2402357952

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.