Evidence map›Paper›PMID 27206635›Full record

ArticleBMC dermatology2016

Nipple adenoma in a female patient presenting with persistent erythema of the right nipple skin: case report, review of the literature, clinical implications, and relevancy to health care providers who evaluate and treat patients with dermatologic conditions of the breast skin.

Gina P Spohn, Shannon C Trotter, Gary Tozbikian, Stephen P Povoski

Open access · diamondAbstract readCase Reports
In one paragraph

Article in BMC dermatology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
3.4field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 57 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Nipple Adenoma: Systematic Review of Literature.Plastic and reconstructive surgery. Global open · 2024
    Article
  5. Article
  6. [Therapeutic peculiarities in diseases of the nipple skin].Dermatologie (Heidelberg, Germany) · 2022
    Review
  7. Article
  8. A tale of three common nipple diseases.Proceedings (Baylor University. Medical Center) · 2022
    Article
  9. Article
  10. Article
  11. Dermoscopy of nipple adenoma.Clinical case reports · 2020
    Article
  12. Nipple Ultrasound: A Pictorial Essay.Korean journal of radiology · 2020
    Review
  13. Article
  14. Article
  15. Erosive Adenomatosis of the Nipple: A Clinical Diagnostic Challenge.Clinical, cosmetic and investigational dermatology · 2020
    Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Gina P SpohnDivision of Dermatology, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, 43210, OH, USA. gina.spohn@osumc.edu.
Shannon C TrotterDivision of Dermatology, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, 43210, OH, USA.
Gary TozbikianDepartment of Pathology, The Ohio State University Wexner Medical Center, Columbus, 43210, OH, USA.
Stephen P PovoskiDivision of Surgical Oncology, Department of Surgery, Arthur G. James Cancer Hospital and Richard J. Solove Research Institute and Comprehensive Cancer Center, The Ohio State University Wexner Medical Center, Columbus, 43210, OH, USA. stephen.povoski@osumc.edu.
The Ohio State University Wexner Medical Center · USThe Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNipple adenoma is a very uncommon, benign proliferative process of lactiferous ducts of the nipple. Clinically, it often presents as a palpable nipple nodule, a visible nipple skin erosive lesion, and/or with discharge from the surface of the nipple skin, and is primarily seen in middle-aged women. Resultantly, nipple adenoma can clinically mimic the presentation of mammary Paget's disease of the nipple. The purpose of our current case report is to present a comprehensive review of the available data on nipple adenoma, as well as provide useful information to health care providers (including dermatologists, breast health specialists, and other health care providers) who evaluate patients with dermatologic conditions of the breast skin for appropriately clinically recognizing, diagnosing, and treating patients with nipple adenoma. CASE PRESENTATION: Fifty-three year old Caucasian female presented with a one year history of erythema and induration of the skin of the inferior aspect of the right nipple/areolar region. Skin punch biopsies showed subareolar duct papillomatosis. The patient elected to undergo complete surgical excision with right central breast resection. Final histopathologic evaluation confirmed nipple adenoma. The patient is doing well 31 months after her definitive surgical therapy.

conclusionsSince nipple adenoma represents a benign proliferative process of the nipple, complete surgical excision is curative. However, the coexistence of nipple adenoma and ipsilateral or contralateral breast cancer is well reported in the literature. The potential for a direct causal link or association of nipple adenoma and breast cancer cannot be fully excluded.

Indexed as

AdenomaBreast NeoplasmsErythemaFemaleHumansMiddle AgedNipplesAdenomaAdenomatosisBreastCase reportErosiveNipplePapillomatosisProliferation

Identifiers

PMID27206635
PMCPMC4873987
OpenAlexW2406985728

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.