Evidence map›Paper›PMID 27206556›Full record

ArticleJournal of cancer research and clinical oncology2016

High-risk and low-risk gastric cancer areas in Italy and its association with microsatellite instability.

Karol Polom, Daniele Marrelli, Valeria Pascale, Giandomenico Roviello, Costantino Voglino, Henry Rho, Carla Vindigni, Mario Marini, Raffaele Macchiarelli, Franco Roviello

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cancer research and clinical oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Karol PolomGeneral Surgery and Surgical Oncology Department, University of Siena, viale Bracci 16, 53-100, Siena, Italy. polom.karol@gmail.com.
Daniele MarrelliGeneral Surgery and Surgical Oncology Department, University of Siena, viale Bracci 16, 53-100, Siena, Italy.
Valeria PascaleGeneral Surgery and Surgical Oncology Department, University of Siena, viale Bracci 16, 53-100, Siena, Italy.
Giandomenico RovielloSection of Pharmacology and University Center DIFF-Drug Innovation Forward Future, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
Costantino VoglinoGeneral Surgery and Surgical Oncology Department, University of Siena, viale Bracci 16, 53-100, Siena, Italy.
Henry RhoUniversity of Medical Sciences, Poznan, Poland.
Carla VindigniDepartment of Pathology, Azienda Ospedaliera Universitaria Senese, Siena, Italy.
Mario MariniDepartment of Medicine, Surgery and Neurosciences, Unit of Endoscopy and Gastroenterology, University of Siena, Siena, Italy.
Raffaele MacchiarelliDepartment of Medicine, Surgery and Neurosciences, Unit of Endoscopy and Gastroenterology, University of Siena, Siena, Italy.
Franco RovielloGeneral Surgery and Surgical Oncology Department, University of Siena, viale Bracci 16, 53-100, Siena, Italy.
University of Siena · ITAzienda Ospedaliera Universitaria Senese · ITPoznan University of Medical Sciences · PLUniversity of Brescia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe different pathological characteristics and prognoses between gastric cancer patients coming from high-risk (group A) and low-risk (group B) areas of Italy were analyzed. We investigated a suspected difference in microsatellite instability (MSI) between these two groups.

methodsMSI analyses of 452 gastric cancer patients were performed using five quasimonomorphic mononucleotide repeats NR-21, NR-24, NR-27, BAT-25, and BAT-26. MSI analysis was done by PCR usage. An allelic profile of these five mononucleotides was detected on an automated DNA sequencer ABI PRISM 3100 Genetic Analyser. Data were analyzed according to high-risk and low-risk gastric cancer areas.

resultsMSI was observed in 23.9 % of all gastric cancer patients studied. Patients from group A showed a higher rate of MSI (28.4 %) than from group B (13.5 %) (p < 0.001). We analyzed this association together with tumor location and Lauren classification: A nonsignificant differences were seen when analyzing cardia and non-cardia tumors (p = 0.854) but significant for Lauren histotype (p = 0.028). There was no statistical difference in survival between high-risk and low-risk areas (p = 0.437), with a nonsignificant trend for better survival in the high-risk group, especially when measured over a longer period of time. Analyzing MSI or MSS in these groups, the survival curves were almost the same.

conclusionsA higher frequency of MSI in patients coming from high-risk areas may help explain geographical differences in gastric cancer. The trend of better survival in high-risk areas may be due to a higher rate of MSI gastric cancer patients.

Indexed as

Genetic Predisposition to DiseaseMicrosatellite InstabilityAgedFemaleHumansItalyMaleStomach NeoplasmsCancer riskGastric cancerMicrosatellite instabilityMolecular

Identifiers

PMID27206556
PMCPMC11819293
OpenAlexW2401125655

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.