Evidence map›Paper›PMID 27206546›Full record

ArticleHormones and behavior2016

Divergence along the gonadal steroidogenic pathway: Implications for hormone-mediated phenotypic evolution.

Kimberly A Rosvall, Christine M Bergeon Burns, Sonya P Jayaratna, Ellen D Ketterson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hormones and behavior, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Testosterone regulatesProceedings. Biological sciences · 2020
    Article
  7. Review
  8. Article
  9. Article
  10. Evolution of the androgen-induced male phenotype.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2018
    Review
  11. Review
  12. Lipid signaling and fat storage in the dark-eyed junco.General and comparative endocrinology · 2017
    Article
  13. Gonads and the evolution of hormonal phenotypes.Integrative and comparative biology · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Kimberly A RosvallDepartment of Biology, Indiana University, 1001 E. Third Street, Bloomington, IN 47405, USA; Center for the Integrative Study of Animal Behavior, Indiana University, 1001 E. Third Street, Bloomington, IN 47405, USA. Electronic address: krosvall@indiana.edu.
Christine M Bergeon BurnsCenter for the Integrative Study of Animal Behavior, Indiana University, 1001 E. Third Street, Bloomington, IN 47405, USA.
Sonya P JayaratnaDepartment of Biology, Indiana University, 1001 E. Third Street, Bloomington, IN 47405, USA.
Ellen D KettersonDepartment of Biology, Indiana University, 1001 E. Third Street, Bloomington, IN 47405, USA; Center for the Integrative Study of Animal Behavior, Indiana University, 1001 E. Third Street, Bloomington, IN 47405, USA.

Funding

Common Themes in Reproductive DiversityT32HD049336 · NICHD · TRUSTEES OF INDIANA UNIVERSITY · PI DALE R SENGELAUB · 2005 to 2026
$4.4M
Integration and independence of neuroendocrine mechanisms of behaviorF32HD068222 · NICHD · TRUSTEES OF INDIANA UNIVERSITY · PI ROSVALL, KIMBERLY ANNE · 2011 to 2011
$51k
NICHD NIH HHS F32 HD068222NICHD NIH HHS T32 HD049336
6 · The paper itself

Abstract

Across a range of taxa, hormones regulate suites of traits that influence survival and reproductive success; however, the mechanisms by which hormone-mediated traits evolve are still unclear. We hypothesized that phenotypic divergence might follow from differential regulation of genes encoding key steps in hormone biosynthesis and thus the rate of hormone production. We tested this hypothesis in relation to the steroid hormone testosterone by comparing two subspecies of junco (Junco hyemalis) in the wild and in captivity. These subspecies have diverged over the last 10-15kyears in multiple testosterone-mediated traits, including aggression, ornamentation, and body size. We show that variation in gonadal gene expression along the steroid biosynthetic pathway predicts phenotypic divergence within and among subspecies, and that the more androgenized subspecies exhibits a more prolonged time-course of elevated testosterone following exogenous stimulation. Our results point to specific genes that fulfill key conditions for phenotypic evolution because they vary functionally in their expression among individuals and between populations, and they map onto population variation in phenotype in a common garden. Our findings therefore build an important bridge between hormones, genes, and phenotypic evolution.

Indexed as

Biological EvolutionGene ExpressionPhenotypeAggressionAnimalsBehavior, AnimalBody SizeGonadsMalePasseriformesSpecies SpecificityTestosteroneTestosterone3-β-Hydroxysteroid-dehydrogenaseCytochrome p450 17α-hydroxylaseCytochrome p450 side-chain cleavageIndividual variationSteroidogenic acute regulatory proteinTestes

Identifiers

PMID27206546
PMCPMC4996689

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.