ArticleBMC neurology2016
Demyelination as a harbinger of lymphoma: a case report and review of primary central nervous system lymphoma preceded by multifocal sentinel demyelination.
Article in BMC neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 50 citations in OpenAlex.
- Tumefactive Multiple Sclerosis Mimicking a High-Grade Glioma: A Case Report and Literature Review.Reports (MDPI) · 2026Article
- Primary central nervous system lymphoma and tumefactive demyelinating lesions in multiple sclerosis: a retrospective observational cohort study.Frontiers in oncology · 2026Article
- Case Report: Post-transplant lymphoproliferative disorder mimicking Baló's concentric sclerosis.Frontiers in oncology · 2026Article
- Primary large B-cell lymphoma of the central nervous system mimicking inflammatory myelitis at initial presentation.Journal of clinical and experimental hematopathology : JCEH · 2025Article
- Multiple sclerosis: a practical review for pathologists.Journal of pathology and translational medicine · 2025Article
- Paraneoplastic Tumefactive Demyelination With Underlying Anaplastic Thyroid Cancer: A Case Report and Review of the Literature.Journal of central nervous system disease · 2025Article
- Case Report: Hypothalamic demyelinating lesion preceding lymphoma arising outside the central nervous system.Frontiers in oncology · 2025Article
- CSF sphingolipids are correlated with neuroinflammatory cytokines and differentiate neuromyelitis optica spectrum disorder from multiple sclerosis.Journal of neurology, neurosurgery, and psychiatry · 2024Article
- A Single-Center Experience: Integrated Management in Primary Central Nervous System Lymphoma.Cureus · 2024Article
- Tumefactive demyelinating lesion and bilateral optic neuritis in a paediatric myelin oligodendrocyte glycoprotein antibody-associated disease.BMJ case reports · 2023Article
- Myelin oligodendrocyte glycoprotein antibody-associated disease preceding primary central nervous system lymphoma: causality or coincidence?Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Article
- Inflammatory brain lesions preceding primary central nervous system lymphoma: a case report and genetic analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Review
- The value of convolutional neural networks-based deep learning model in differential diagnosis of space-occupying brain diseases.Frontiers in neurology · 2023Article
- Neuroimaging and clinicopathological differences between tumefactive demyelinating lesions and sentinel lesions of primary central nervous system lymphoma.Frontiers in immunology · 2022Article
- Demyelinating sentinel lesion preceding a primary central nervous system lymphoma.Arquivos de neuro-psiquiatria · 2022Article
- Immunopathology of Tumefactive Demyelinating Lesions-From Idiopathic to Drug-Related Cases.Frontiers in neurology · 2022Review
- Sentinel inflammatory demyelinating lesions preceding primary CNS lymphoma.Arquivos de neuro-psiquiatria · 2021Article
- Primary Central Nervous System Lymphoma Mimicking Longitudinally Extensive Transverse Myelitis.The Neurohospitalist · 2021Article
- Inflammatory Brain Lesions as Omen of Primary Central Nervous System Lymphoma: A Case Report and Literature Review.Brain sciences · 2021Article
- Progressive Tumefactive Demyelination as the Only Result of Extensive Diagnostic Work-Up: A Case Report.Frontiers in neurology · 2021Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrimary central nervous system lymphoma (PCNSL) may rarely be preceded by "sentinel demyelination," a pathologic entity characterized by histologically confirmed demyelinating inflammatory brain lesions that mimic multiple sclerosis (MS) or acute disseminated encephalomyelitis (ADEM). Interpreting the overlapping radiologic and clinical characteristics associated with each of these conditions-contrast-enhancing demyelination of white matter and relapsing and remitting steroid-responsive symptoms respectively-can be a significant diagnostic challenge. CASE PRESENTATION: We describe a 57-year-old woman with an unusual clinical course who presented with multi-focal enhancing white matter lesions demonstrated to be inflammatory demyelination by brain biopsy. Despite a good initial response to steroids and rituximab for treatment of presumed tumefactive multiple sclerosis, the patient's condition rapidly deteriorated, and a repeat brain biopsy six months later was consistent with a diagnosis of diffuse large B-cell lymphoma.
conclusionsEarly clinical suspicion for PCNSL and awareness that biopsied lesions may initially show sentinel demyelination suggestive of alternate diagnoses may be essential for early initiation of appropriate therapies and mitigation of disease progression. Clinical, pathophysiological, and diagnostic aspects of sentinel demyelination and PCNSL are discussed.
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