ArticleBMC genomics2016
Flashy flagella: flagellin modification is relatively common and highly versatile among the Enterobacteriaceae.
Article in BMC genomics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 43 citations in OpenAlex.
- Flagellar glycosylation with pseudaminic acids is widespread in the genus Clostridium.BMC microbiology · 2026Article
- How flagellar glycosylation of the phytopathogenic bacteriumApplied and environmental microbiology · 2026Article
- Distinct microbial and functional alterations across skin sites and disease severity in pediatric atopic dermatitis: a prospective study.Frontiers in medicine · 2026Article
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- Inhibitors of Lysinoalanine Cross-Linking in the Flagella Hook as Antimicrobials against Spirochetes.ACS chemical biology · 2025Article
- A flagella-dependentmBio · 2025Article
- Changes in potential pathogenicity-associated proteins ofFrontiers in microbiology · 2025Article
- Phages on filaments: A genetic screen elucidates the complex interactions between Salmonella enterica flagellin and bacteriophage Chi.PLoS pathogens · 2023Article
- Flagellin lysine methyltransferase FliB catalyzes a [4Fe-4S] mediated methyl transfer reaction.PLoS pathogens · 2021Article
- Draft Genome Sequence of Enterobacter mori Strain NSE2, Isolated from the Rhizosphere of aMicrobiology resource announcements · 2021Article
- Flagellar Structures from the Bacterium Caulobacter crescentus and Implications for PhageJournal of bacteriology · 2021Article
- Article
- Flagella by numbers: comparative genomic analysis of the supernumerary flagellar systems among the Enterobacterales.BMC genomics · 2020Article
- Methylation of Salmonella Typhimurium flagella promotes bacterial adhesion and host cell invasion.Nature communications · 2020Article
- Comparative genomic analysis of the secondary flagellar (flag-2) system in the order Enterobacterales.BMC genomics · 2020Article
- Distinct but Intertwined Evolutionary Histories of Multiple Salmonella enterica Subspecies.mSystems · 2020Article
- Polar Flagella Glycosylation inFrontiers in microbiology · 2020Article
- Article
- Duplicate divergence of two bacterial small heat shock proteins reduces the demand for Hsp70 in refolding of substrates.PLoS genetics · 2019Article
- Pantoea ananatis: genomic insights into a versatile pathogen.Molecular plant pathology · 2017Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPost-translational glycosylation of the flagellin protein is relatively common among Gram-negative bacteria, and has been linked to several phenotypes, including flagellar biosynthesis and motility, biofilm formation, host immune evasion and manipulation and virulence. However to date, despite extensive physiological and genetic characterization, it has never been reported for the peritrichously flagellate Enterobacteriaceae.
resultsUsing comparative genomic approaches we analyzed 2,000 representative genomes of Enterobacteriaceae, and show that flagellin glycosylation islands are relatively common and extremely versatile among members of this family. Differences in the G + C content of the FGIs and the rest of the genome and the presence of mobile genetic elements provide evidence of horizontal gene transfer occurring within the FGI loci. These loci therefore encode highly variable flagellin glycan structures, with distinct sugar backbones, heavily substituted with formyl, methyl, acetyl, lipoyl and amino groups. Additionally, an N-lysine methylase, FliB, previously identified only in the enterobacterial pathogen Salmonella enterica, is relatively common among several distinct taxa within the family. These flagellin methylase island loci (FMIs), in contrast to the FGI loci, appear to be stably maintained within these diverse lineages.
conclusionsThe prevalence and versatility of flagellin modification loci, both glycosylation and methylation loci, suggests they play important biological roles among the Enterobacteriaceae.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.