Evidence map›Paper›PMID 27206422›Full record

ReviewNeurosurgical review2017

Seizure outcomes in nonresective epilepsy surgery: an update.

Dario J Englot, Harjus Birk, Edward F Chang

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neurosurgical review, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 2 pooled it
6.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 79 citations in OpenAlex.

  1. Pooled it
  2. Deep brain stimulation for refractory temporal lobe epilepsy: a systematic review and meta-analysis with an emphasis on alleviation of seizure frequency outcome.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Dario J EnglotDepartment of Neurological Surgery and UCSF Epilepsy Center, University of California, San Francisco, 505 Parnassus Avenue, Box 0112, M779, San Francisco, CA, 94143-0112, USA. englot@gmail.com.
Harjus BirkDepartment of Neurological Surgery and UCSF Epilepsy Center, University of California, San Francisco, 505 Parnassus Avenue, Box 0112, M779, San Francisco, CA, 94143-0112, USA.
Edward F ChangDepartment of Neurological Surgery and UCSF Epilepsy Center, University of California, San Francisco, 505 Parnassus Avenue, Box 0112, M779, San Francisco, CA, 94143-0112, USA.
Neurological Surgery · USUniversity of California, San Francisco · US

Funding

Resting-State Functional Connectivity Analysis in Focal Neocortical EpilepsyF32NS086353 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ENGLOT, DARIO J · 2014 to 2014
$59k
NINDS NIH HHS F32 NS086353
6 · The paper itself

Abstract

In approximately 30 % of patients with epilepsy, seizures are refractory to medical therapy, leading to significant morbidity and increased mortality. Substantial evidence has demonstrated the benefit of surgical resection in patients with drug-resistant focal epilepsy, and in the present journal, we recently reviewed seizure outcomes in resective epilepsy surgery. However, not all patients are candidates for or amenable to open surgical resection for epilepsy. Fortunately, several nonresective surgical options are now available at various epilepsy centers, including novel therapies which have been pioneered in recent years. Ablative procedures such as stereotactic laser ablation and stereotactic radiosurgery offer minimally invasive alternatives to open surgery with relatively favorable seizure outcomes, particularly in patients with mesial temporal lobe epilepsy. For certain individuals who are not candidates for ablation or resection, palliative neuromodulation procedures such as vagus nerve stimulation, deep brain stimulation, or responsive neurostimulation may result in a significant decrease in seizure frequency and improved quality of life. Finally, disconnection procedures such as multiple subpial transections and corpus callosotomy continue to play a role in select patients with an eloquent epileptogenic zone or intractable atonic seizures, respectively. Overall, open surgical resection remains the gold standard treatment for drug-resistant epilepsy, although it is significantly underutilized. While nonresective epilepsy procedures have not replaced the need for resection, there is hope that these additional surgical options will increase the number of patients who receive treatment for this devastating disorder-particularly individuals who are not candidates for or who have failed resection.

Indexed as

Drug Resistant EpilepsyElectric Stimulation TherapyEpilepsyHumansLaser TherapyNeurosurgical ProceduresRadiosurgerySeizuresTreatment OutcomeBrain stimulationDisconnectionEpilepsy surgeryReviewSeizure outcome

Identifiers

PMID27206422
PMCPMC5118196
OpenAlexW2401185702

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.