Evidence map›Paper›PMID 27206415›Full record

ArticleZeitschrift fur Gerontologie und Geriatrie2018

Association between cystatin C and heart failure with preserved ejection fraction in elderly Chinese patients.

C C Xu, G X Fu, Q Q Liu, Y Zhong

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In one paragraph

Article in Zeitschrift fur Gerontologie und Geriatrie, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact, top 62% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

C C XuDepartment of Geriatrics, Shanghai Jiaotong University affiliated Shanghai Sixth People's Hospital, 600 Yishan Road, 200233, Xuhui District, Shanghai, China.
G X FuDepartment of Geriatrics, Shanghai Jiaotong University affiliated Shanghai Sixth People's Hospital, 600 Yishan Road, 200233, Xuhui District, Shanghai, China.
Q Q LiuClinical Laboratory, Shanghai Jiaotong University affiliated Shanghai Sixth People's Hospital, Xuhui District, Shanghai, China.
Y ZhongDepartment of Geriatrics, Shanghai Jiaotong University affiliated Shanghai Sixth People's Hospital, 600 Yishan Road, 200233, Xuhui District, Shanghai, China. zhongyuansh60@163.com.
Shanghai Sixth People's Hospital · CN

Funding

Grants from the science project of the Shanghai Jiaotong University affiliated Shanghai Sixth People's Hospital, China 1529
6 · The paper itself

Abstract

backgroundApproximately 50 % of patients with heart failure have a preserved ejection fraction (HFpEF). Cystatin C has been reported to be associated with cardiovascular events. This study was carried out to investigate whether cystatin C is associated with cardiac function and cardiac diastolic properties in elderly Chinese HFpEF patients. MATERIAL AND

methodsA cross-sectional study of 381 elderly Chinese HFpEF patients (81 women, average age 82 ± 6 years) was conducted. Serum concentrations of cystatin C and the New York Heart Association (NYHA) classification were assessed and early (E) to late (A) transmitral flow velocity ratios (E/A ratio) were measured to assess cardiac diastolic properties.

resultsCystatin C levels, N‑terminal pro brain natriuretic peptide (NT-proBNP) levels and age were significantly correlated to the NYHA class (r = 0.605 P < 0.001, r = 0.333 P < 0.001 and r = 0.254 P < 0.001, respectively). Cystatin C levels, age and body mass index (BMI) were negatively correlated to the E/A ratio (r = -0.224 P = 0.005, r = -0.258 P = 0.001 and r = -0.258 P = 0.003, respectively). The patients with cystatin C concentrations below 1.3 mg/l had a higher E/A ratio compared to those with cystatin C concentrations higher than 1.3 mg/l. Cystatin C was also significantly associated with both the NYHA classification and the E/A ratio even after adjustment for the creatinine clearance rate (CCr).

conclusionBoth cystatin C and NT-proBNP were found to be correlated to the NYHA classification. Independent of renal function, higher serum concentrations of cystatin C were associated with a worse NYHA classification and abnormal cardiac diastolic properties in elderly Chinese HFpEF patients.

Indexed as

AgedAged, 80 and overBlood Flow VelocityBody Mass IndexChinaCorrelation of DataCross-Sectional StudiesCystatin CDiastoleFemaleHeart FailureHumansMaleMitral ValveNatriuretic Peptide, BrainPeptide FragmentsCystatin CNatriuretic Peptide, BrainPeptide Fragmentspro-brain natriuretic peptide (1-76)Cystatin CDiastolic propertiesElderlyHeart failure with preserved ejection fractionNYHA classification

Identifiers

PMID27206415
OpenAlexW4242751623

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.