ArticleEpilepsy & behavior : E&B2016
Differential impact of contraceptive methods on seizures varies by antiepileptic drug category: Findings of the Epilepsy Birth Control Registry.
Article in Epilepsy & behavior : E&B, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A scoping review of hormonal clinical trials in menstrual cycle-related brain disorders: Studies in premenstrual mood disorder, menstrual migraine, and catamenial epilepsy.Frontiers in neuroendocrinology · 2023Pooled it
- Contraceptive management in people with epilepsy: A narrative review of drug interactions, special populations, and clinical guidance.Epileptic disorders : international epilepsy journal with videotape · 2026Review
- Review
- Special Considerations in the Management of Women with Epilepsy in Reproductive Years.Journal of personalized medicine · 2022Review
- Progesterone modulates neuronal excitability bidirectionally.Neuroscience letters · 2021Review
- A Clinical Approach to Catamenial Epilepsy: A Review.The Permanente journal · 2020Review
- Progesterone receptor activation regulates seizure susceptibility.Annals of clinical and translational neurology · 2019Article
- Hormonal contraception is not associated with increased risk for seizures in the general population: results from a cohort study using The Health Improvement Network.European journal of clinical pharmacology · 2018Observational
- Do oral contraceptives increase epileptic seizures?Expert review of neurotherapeutics · 2017Article
- Contraceptive Methods, Seizures, and Antiepileptic Drugs: More Questions Than Answers.Epilepsy currentsArticle
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe aim of this study was to determine whether categories of contraception differ in their impact on seizures in women with epilepsy and whether the impact varies by antiepileptic drug category.
methodsRetrospective survey data came from 2712 contraceptive experiences reported by 1144 women with epilepsy. We compared risk ratios for reports of increase and decrease in seizure frequency on hormonal versus nonhormonal contraception, stratified by antiepileptic drug categories.
resultsMore women with epilepsy reported a change in seizures on hormonal (28.2%) than on nonhormonal contraception (9.7%) (p<0.0001). The risk ratio for seizure increase on hormonal (18.7%) versus nonhormonal contraception (4.2%) was 4.47 (p<0.0001). The risk ratio for seizure decrease on hormonal (9.5%) versus nonhormonal contraception (5.5%) was 1.71, p<0.0001. On hormonal contraception, the risk ratio for seizure increase was greater than for decrease (1.98, p<0.0001). In comparison to combined pills, both hormonal patch and progestin-only pills had greater risk ratios for seizure increase. Depomedroxyprogesterone was the only hormonal method with a greater risk ratio for seizure decrease than combined pills. Seizure increase was greater for hormonal than nonhormonal contraception for each antiepileptic drug category (p<0.001). On hormonal contraception, relative to the non-enzyme-inducing antiepileptic drug category which had the lowest rate, each of the other categories had significantly greater risks for seizure increase, especially the enzyme-inhibiting (valproate) category (risk ratio=2.53, p=0.0002).
conclusionThe findings provide community-based, epidemiological survey evidence that contraceptive methods may differ in their impact on seizures and that this impact may vary by antiepileptic drug category.
Indexed as
Identifiers
27206228What OpenQuestion holds
Registered trials
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