Evidence map›Paper›PMID 27203848›Full record

ArticleJournal of veterinary internal medicine2016

Bacterial Cholangitis, Cholecystitis, or both in Dogs.

A Tamborini, H Jahns, H McAllister, A Kent, B Harris, F Procoli, K Allenspach, E J Hall, M J Day, P J Watson and 1 more

Open access · goldAbstract readMulticenter Study
In one paragraph

Article in Journal of veterinary internal medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 71 citations in OpenAlex.

  1. Animals : an open access journal from MDPI · 2026
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  8. Magnetic Resonance Cholangiopancreatography for Cholangiopancreatic Duct Imaging in Dogs.Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 4 countries.

A TamboriniSchool of Veterinary Medicine, University College Dublin, Dublin, Ireland.
H JahnsSchool of Veterinary Medicine, University College Dublin, Dublin, Ireland.
H McAllisterSchool of Veterinary Medicine, University College Dublin, Dublin, Ireland.
A KentDepartment of Veterinary Medicine, University of Cambridge, Cambridge, UK.
B HarrisDepartment of Veterinary Medicine, University of Cambridge, Cambridge, UK.
F ProcoliDepartment of Veterinary Clinical Sciences, Royal Veterinary College, London, UK.
K AllenspachDepartment of Veterinary Clinical Sciences, Royal Veterinary College, London, UK.
E J HallSchool of Veterinary Sciences, University of Bristol, Bristol, UK.
M J DaySchool of Veterinary Sciences, University of Bristol, Bristol, UK.
P J WatsonDepartment of Veterinary Medicine, University of Cambridge, Cambridge, UK.
E J O'NeillSchool of Veterinary Medicine, University College Dublin, Dublin, Ireland.
University College Dublin · IEUniversity of Cambridge · GBRoyal Veterinary College · GBUniversity of Bristol · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBacterial cholangitis and cholecystitis are rarely reported, poorly characterized diseases in the dog.

objectivesTo characterize the clinical features of these conditions. ANIMALS: Twenty-seven client-owned dogs with bacterial cholangitis, cholecystitis, or both.

methodsMulticenter, retrospective cases series of dogs with bacterial cholangitis, cholecystitis, or both, presenting January 2000 to June 2011 to 4 Veterinary Schools in Ireland/United Kingdom. Interrogation of hospital databases identified all cases with the inclusion criteria; histopathologically confirmed cholangitis or cholecystitis and bile culture/cytology results supporting a bacterial etiology.

resultsTwenty-seven dogs met the inclusion criteria with approximately 460 hepatitis cases documented over the same study period. Typical clinical pathology findings were increases in liver enzyme activities (25/26), hyperbilirubinemia (20/26), and an inflammatory leukogram (21/24). Ultrasound findings, although nonspecific, aided decision-making in 25/26 cases. The most frequent hepatobiliary bacterial isolates were Escherichia coli (n = 17; 16 cases), Enterococcus spp. (n = 8; 6 cases), and Clostridium spp. (n = 5; 5 cases). Antimicrobial resistance was an important feature of aerobic isolates; 10/16 E. coli isolates resistant to 3 or more antimicrobial classes. Biliary tract rupture complicated nearly one third of cases, associated with significant mortality (4/8). Discharged dogs had a guarded to fair prognosis; 17/18 alive at 2 months, although 5/10 re-evaluated had persistent liver enzyme elevation 2-12 months later. CONCLUSION AND CLINICAL SIGNIFICANCE: Bacterial cholangitis and cholecystitis occur more frequently than suggested by current literature and should be considered in dogs presenting with jaundice and fever, abdominal pain, or an inflammatory leukogram or with ultrasonographic evidence of gallbladder abnormalities.

Indexed as

AnimalsBacterial InfectionsCholangitisCholecystitisDog DiseasesDogsFemaleIrelandMaleRetrospective StudiesUnited KingdomCanineCholangiohepatitisHepatitisLiver disease

Identifiers

PMID27203848
PMCPMC5084764
OpenAlexW2400351101

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.