ArticlePhysical review letters2016
Role of Turnover in Active Stress Generation in a Filament Network.
Article in Physical review letters, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Rapid actin filament turnover maintains cortical connectivity while allowing for cell cortex deformation and flow.bioRxiv : the preprint server for biology · 2026Article
- Myosin-induced F-actin fragmentation facilitates contraction of actin networks.Cytoskeleton (Hoboken, N.J.) · 2024Article
- Cytosolic concentrations of actin binding proteins and the implications for in vivo F-actin turnover.The Journal of cell biology · 2023Article
- Actomyosin-Driven Division of a Synthetic Cell.ACS synthetic biology · 2022Review
- Protein friction and filament bending facilitate contraction of disordered actomyosin networks.Biophysical journal · 2021Article
- Nonlinear Elastic and Inelastic Properties of Cells.Journal of biomechanical engineering · 2020Review
- Tug-of-war between actomyosin-driven antagonistic forces determines the positioning symmetry in cell-sized confinement.Nature communications · 2020Article
- Stratification relieves constraints from steric hindrance in the generation of compact actomyosin asters at the membrane cortex.Science advances · 2020Article
- The Actin Cytoskeleton as an Active Adaptive Material.Annual review of condensed matter physics · 2020Article
- Dynamic motions of molecular motors in the actin cytoskeleton.Cytoskeleton (Hoboken, N.J.) · 2019Article
- Scaling behaviour in steady-state contracting actomyosin networks.Nature physics · 2019Article
- Effects of spatial dimensionality and steric interactions on microtubule-motor self-organization.Physical biology · 2019Article
- Article
- Unite to divide - how models and biological experimentation have come together to reveal mechanisms of cytokinesis.Journal of cell science · 2018Review
- Balance between Force Generation and Relaxation Leads to Pulsed Contraction of Actomyosin Networks.Biophysical journal · 2018Article
- Nonequilibrium phase diagrams for actomyosin networks.Soft matter · 2018Article
- The actin filament bundling protein α-actinin-4 actually suppresses actin stress fibers by permitting actin turnover.The Journal of biological chemistry · 2018Article
- The actin cortex at a glance.Journal of cell science · 2018Review
- Filament turnover tunes both force generation and dissipation to control long-range flows in a model actomyosin cortex.PLoS computational biology · 2017Article
- A theory that predicts behaviors of disordered cytoskeletal networks.Molecular systems biology · 2017Article
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Authors and funding
2 authors.
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Abstract
We study the effect of turnover of cross-linkers, motors, and filaments on the generation of a contractile stress in a network of filaments connected by passive cross-linkers and subjected to the forces exerted by molecular motors. We perform numerical simulations where filaments are treated as rigid rods and molecular motors move fast compared to the time scale of an exchange of cross-linkers. We show that molecular motors create a contractile stress above a critical number of cross-linkers. When passive cross-linkers are allowed to turn over, the stress exerted by the network vanishes due to the formation of clusters. When both filaments and passive cross-linkers turn over, clustering is prevented and the network reaches a dynamic contractile steady state. A maximum stress is reached for an optimum ratio of the filament and cross-linker turnover rates. Taken together, our work reveals conditions for stress generation by molecular motors in a fluid isotropic network of rearranging filaments.
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