ArticlePloS one2016
The Effects of Cigarette Smoke Condensate and Nicotine on Periodontal Tissue in a Periodontitis Model Mouse.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- What is the impact of nicotine pouches on oral health: a systematic review.BMC oral health · 2024Pooled it
- Systematic review of longitudinal studies on the association between cluster of health-related behaviors and tooth loss among adults.Acta odontologica Scandinavica · 2024Pooled it
- The associations between volatile organic compounds and bone loss around teeth among US adults.BMC public health · 2026Article
- Social Support and Functional Dentition Among English Older Adults.Dentistry journal · 2025Article
- Health-Related Behaviour Clusters and Functional Dentition in Older People.Gerodontology · 2025Article
- Article
- Investigating oral nicotine pouch use among adults in Riyadh, Saudi Arabia: prevalence, awareness, susceptibility, and associated symptoms.Frontiers in public health · 2025Article
- Anti-inflammatory effectiveness ofBiochemistry and biophysics reports · 2024Article
- A Flagellin-Adjuvanted Trivalent Mucosal Vaccine Targeting Key Periodontopathic Bacteria.Vaccines · 2024Article
- Smoking and osteoimmunology: Understanding the interplay between bone metabolism and immune homeostasis.Journal of orthopaedic translation · 2024Review
- Evaluation of implants in smoking and non-smoking patients with peri-implant disease risk analysis and esthetic scores: an observational study.BMC oral health · 2023Observational
- Emerging Oral Nicotine Products and Periodontal Diseases.International journal of dentistry · 2023Review
- Associations between dental caries and systemic diseases: a scoping review.BMC oral health · 2021Article
- Application of Ligature-Induced Periodontitis in Mice to Explore the Molecular Mechanism of Periodontal Disease.International journal of molecular sciences · 2021Review
- Periodontal Wound Healing and Tissue Regeneration: A Narrative Review.Pharmaceuticals (Basel, Switzerland) · 2021Review
- Zbp1-positive cells are osteogenic progenitors in periodontal ligament.Scientific reports · 2021Article
- Host-microbe interactions: Profiles in the transcriptome, the proteome, and the metabolome.Periodontology 2000 · 2020Review
- Smoking increases the risk of infectious diseases: A narrative review.Tobacco induced diseases · 2020Review
- Permanence of Modifications in Oral Microcirculation in Ex-Smokers.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- Mucosal Exposure to Cigarette Components Induces Intestinal Inflammation and Alters Antimicrobial Response in Mice.Frontiers in immunology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cigarette smoking is a major lifestyle-related risk factor for periodontal diseases. However, the pathophysiological role of cigarette smoking in periodontal disease has yet to be fully elucidated. Here we report that the systemic administration of cigarette smoke condensate or nicotine, which is the major ingredient of cigarette smoke, augmented alveolar bone loss. Concomitantly, the number of osteoclasts in periodontal tissues increased and the expression of receptor activator of nuclear factor κB ligand was upregulated at the ligated side in mice with periodontitis. Nicotine also attenuated alveolar bone repair after ligature removal. These observations highlight the destruction of periodontal tissue by smoking and the unfavorable clinical course of periodontal disease in patients with a cigarette smoking habit. The present study demonstrates that periodontal disease models are useful for elucidating the pathogenesis of cigarette smoking-related periodontal diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.