Evidence map›Paper›PMID 27200505›Full record

ArticleInternational journal of obesity (2005)2016

Recovery of brain structural abnormalities in morbidly obese patients after bariatric surgery.

Y Zhang, G Ji, M Xu, W Cai, Q Zhu, L Qian, Y E Zhang, K Yuan, J Liu, Q Li and 11 more

2 registry-linked trialsAbstract read
PubMed Publisher
In one paragraph

Article in International journal of obesity (2005), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 45 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 3 pooled it
7.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03528044 nacompletednot on this mapstarted 2017, after this paper: background citation

Evaluation and Follow up of Emotional Regulation, Cognition, Impulsivity and Reward System in Obesity, and Determination of Its Biopsychosocial Risk Factors: A Prospective Study of Obese Patients Before and After Bariatric Surgery

TypeinterventionalSponsorKoç UniversityRan2017 to 2022Enrolled50ConditionsObesity, Cognitive DisorderArmsBariatric surgery
NCT03547063 suspendednot on this mapstarted 2018, after this paper: background citation

Responses to Appetite and Taste in the Brain Circuits That Control Eating Behaviour: An fMRI Study Evaluating Brain Structure, Connectivity and Responses to Taste Across Different Body Weight Categories and in Response to Weight Loss

TypeobservationalSponsorUniversity College, LondonRan2018 to 2022Enrolled75ConditionsObesity
3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 3 syntheses or guidelines pooled it, 86 citations in OpenAlex.

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  18. Is there a role for higher cognitive processes in the development of obesity in humans?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 7 institutions in 2 countries.

Y ZhangCenter for Brain Imaging, School of Life Science and Technology, Xidian University, Xi'an, China.
G JiXijing Gastrointestinal Hospital, the Fourth Military Medical University, Xi'an, China.
M XuDepartment of Biomedical Engineering, Peking University, Beijing, China.
W CaiCenter for Brain Imaging, School of Life Science and Technology, Xidian University, Xi'an, China.
Q ZhuCenter for Brain Imaging, School of Life Science and Technology, Xidian University, Xi'an, China.
L QianDepartment of Biomedical Engineering, Peking University, Beijing, China.
Y E ZhangDepartment of Psychiatry and McKnight Brain Institute, University of Florida, Gainesville, FL, USA.
K YuanCenter for Brain Imaging, School of Life Science and Technology, Xidian University, Xi'an, China.
J LiuCenter for Brain Imaging, School of Life Science and Technology, Xidian University, Xi'an, China.
Q LiDepartment of Radiology, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.
G CuiDepartment of Radiology, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.
H WangDepartment of Psychiatry, Xijing Hospital, the Fourth Military Medical University, Xi'an, China.
Q ZhaoXijing Gastrointestinal Hospital, the Fourth Military Medical University, Xi'an, China.
K WuXijing Gastrointestinal Hospital, the Fourth Military Medical University, Xi'an, China.
D FanXijing Gastrointestinal Hospital, the Fourth Military Medical University, Xi'an, China.
M S GoldDepartment of Psychiatry and McKnight Brain Institute, University of Florida, Gainesville, FL, USA.
J TianCenter for Brain Imaging, School of Life Science and Technology, Xidian University, Xi'an, China.
D TomasiLaboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, USA.
Y LiuDepartment of Psychiatry and McKnight Brain Institute, University of Florida, Gainesville, FL, USA.
Y NieXijing Gastrointestinal Hospital, the Fourth Military Medical University, Xi'an, China.
G-J WangLaboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, USA.
Air Force Medical University · CNXidian University · CNPeking University · CNUniversity of Florida · USNational Institute on Alcohol Abuse and Alcoholism · USShandong Institute of Automation · CNXijing Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesObesity-related brain structural abnormalities have been reported extensively, and bariatric surgery (BS) is currently the most effective intervention to produce sustained weight reduction in overtly obese (OB) people. It is unknown whether BS can repair the brain circuitry abnormalities concomitantly with long-term weight loss. SUBJECTS/

methodsIn order to investigate whether BS promotes neuroplastic structural recovery in morbidly OB patients, we quantified fractional anisotropy (FA), mean diffusivity (MD) and gray (GM) and white (WM) matter densities in 15 morbidly OB patients and in 18 normal weight (NW) individuals. OB patients were studied at baseline and also 1 month after laparoscopic sleeve gastrectomy surgery.

resultsTwo-sample t-test between OB (baseline) and NW groups showed decreased FA values, GM/WM densities and increased MD value in brain regions associated with food intake control (that is, caudate, orbitofrontal cortex, body and genu of corpus callosum) and cognitive-emotion regulation (that is, inferior frontal gyrus, hippocampus, insula, external capsule) (P<0.05, family-wise error correction). Paired t-test in the OB group between before and after surgery showed that BS generated partial neuroplastic structural recovery in the OB group, but the differences had relative less strength and smaller volume (P<0.001).

conclusionsThis study provides the first anatomical evidence for BS-induced acute neuroplastic recovery that might in part mediate the long-term benefit of BS in weight reduction. It also highlights the importance of this line of gut-brain axis research employing the combined BS and neuroimaging model for identifying longitudinal changes in brain structure that correlated with obesity status.

Indexed as

Bariatric SurgeryDiffusion Tensor ImagingNeuroimagingAdultChinaCognitionCorpus CallosumEmotionsFeeding BehaviorFemaleHippocampusHumansMaleNeural PathwaysObesity, MorbidPostoperative Period

Identifiers

PMID27200505
OpenAlexW2406406058

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.