ArticleInternational journal of reproductive biomedicine2016
Protective effect of methanolic extract of Berberis integerrima Bunge. root on carbon tetrachloride-induced testicular injury in Wistar rats.
Article in International journal of reproductive biomedicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 21 citations in OpenAlex.
- Review
- Medicinal Species of the Genus Berberis: A Review of Their Traditional and Ethnomedicinal Uses, Phytochemistry and Pharmacology.Advances in experimental medicine and biology · 2021Review
- Antioxidant Potential of Parsley Leaf (BioMed research international · 2021Article
- Plants-Derived Biomolecules as Potent Antiviral Phytomedicines: New Insights on Ethnobotanical Evidences against Coronaviruses.Plants (Basel, Switzerland) · 2020Review
- The effect of hydroalcoholic Berberis integerrima fruits extract on the lipid profile, antioxidant parameters and liver and kidney function tests in patients with nonalcoholic fatty liver disease.Saudi journal of biological sciences · 2020Article
- Rutin ameliorates carbon tetrachloride (CClPeerJ · 2019Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTissue protective effect of compounds with antioxidant properties has been demonstrated. The alkaloids found in barberry root are considered as antioxidants.
objectiveAccording to barberry protective effects in different tissues, in this study, the protective effect of Berberis integerrima Bge. root )MEBIR) was evaluated against CCl4-induced testicular damages in Wistar rats. MATERIALS AND
methods40 mature male rats were randomly divided into 5 groups: 1: Normal control, 2: Sham: received CCl4 diluted in olive oil (50% v/v; 1ml/kg bw), intraperitoneally, twice a week for 4 weeks, 3 and 4: Sham rats treated with MEBIR (250 and 500 mg/kg bw) for 28 days, 5: Sham rats treated with silymarin (50 mg/kg bw) for 28 days. After 28 days, serum testosterone level, absolute testis weight, catalase activity, malondialdehyde level, and histological parameters were investigated.
resultsIn the treated rats with MEBIR (250 and 500 mg/kg bw) or silymarin (50 mg/kg bw), there was a significant increase in the absolute testis weight, testosterone level, seminiferous tubules diameter (p<0.001), thickness of the epithelium, tubule differentiation index) p<0.001), spermiogenesis index (p<0.001), the activity of catalase, and a significant decrease in interstitial tissue thickness (p<0.001) and malondialdehyde level in comparison with CCl4-treated group. The effect of the MEBIR at dose of 500 mg/kg bw is more than that of the standard drug, silymarin (50 mg/kg bw).
conclusionFrom the results, it is suggested that the protective effects of MEBIR is possibly due to antioxidant effects of its bioactive compounds.
Indexed as
Identifiers
27200428PMC4869158W2296632536What OpenQuestion holds
Registered trials
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