ArticleInternational journal of reproductive biomedicine2016
Effect of Genistein on reproductive parameter and serum nitric oxide levels in morphine-treated mice.
Article in International journal of reproductive biomedicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 53 citations in OpenAlex.
- Antinociceptive Role of β-alanine in Hot Plate-induced Pain in Mice.Archives of Razi Institute · 2025Article
- The effects of modest intake of soy milk enriched with Lactobacillus casei and omega-3 on the testis parameters in diabetic rats: a stereological study.International urology and nephrology · 2025Article
- Sex and dose differences in morphine administration on renal function, inflammatory and apoptotic markers in male and female Wistar rats.Current research in physiology · 2025Article
- The Therapeutic Role of Genistein in Perimenopausal and Postmenopausal Women.The Journal of clinical and aesthetic dermatology · 2024Review
- Influence of substance use on male reproductive health and offspring outcomes.Nature reviews. Urology · 2024Review
- Evaluation of the Effect of Vitamin E on Reproductive Parameters in Morphine-Treated Male Mice.Addiction & health · 2023Article
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- Opioid replacement therapy with methadone or buprenorphine effects on male mice reproduction.Psychopharmacology · 2023Article
- Prenatal Exposure to L-Citrulline Has Positive Effects on Reflexive Motor Behavior in Newborn Mice.Archives of Razi Institute · 2022Article
- The effects of morphine abuse on sperm parameters, chromatin integrity and apoptosis in men.JBRA assisted reproduction · 2022Article
- The Role of Selected Natural Biomolecules in Sperm Production and Functionality.Molecules (Basel, Switzerland) · 2021Review
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- Effect of Co-exposure to Heat and Psychological Stressors on Sperm DNA and Semen Parameters.Toxicology reports · 2021Article
- Evaluation of male infertility treatment following Rhus coriaria extract administration on rats exposed to morphine.Molecular biology reports · 2020Article
- Protective effects ofInternational journal of reproductive biomedicine · 2020Article
- Effect of Herbal Medicine on Fertility Potential in Experimental Animals - an Update Review.Materia socio-medica · 2020Review
- Genistein improve nicotine toxicity on male mice pancreas.Anatomy & cell biology · 2019Article
- The Impact ofIranian journal of medical sciences · 2019Article
- Effects of Crocin on Sperm Parameters and Seminiferous Tubules in Diabetic Rats.Advanced biomedical research · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe predominant phytoestrogen in soy and derived products is the isoflavone Genistein. Genistein has antioxidant properties. Morphine is a main psychoactive chemical in opium that can increase the generation of free radicals and therefore it could adversely affects the spermatogenesis.
objectiveThe main goal was to investigate whether the Genistein could protect morphine adverse effects on sperm cells viability, count, motility, and testis histology and testosterone hormone and nitric oxide in blood serum. MATERIALS AND
methodsIn this study, various doses of Genistein (0, 1, 2, and 3 mg/kg) and Genistein plus morphine (0, 1, 2, and 3 mg/kg) were administered interaperitoneally to 48 male mice for 30 consequent days. These mice were randomly assigned to 8 groups (n=6) and sperm parameters (sperm cells viability, count, motility and morphology), testis weight and histology, testosterone hormone (ELISA method), FSH and LH hormones (immunoradiometry) and serum nitric oxide (griess assay) were analyzed and compared.
resultsThe results indicated that morphine administration significantly decreased testosterone (0.03 ng/mg) LH and FSH level, histological parameters, count, viability (55.3%), morphology and motility of sperm cells (1%), testis weight (0.08 gr) and increase nitric oxide compared to saline group (p=0.00). However, administration of Genistein and Genistein plus morphine significantly boosted motility, morphology, count, viability of sperm cells, seminiferous tubules diameter, germinal thickness, testosterone, LH and FSH while decrease nitric oxide level in all groups compared to morphine group (p<0.025).
conclusionIt seems that Genistein administration could increase the quality of spermatozoa and prevent morphine- induced adverse effects on sperm parameters.
Indexed as
Identifiers
27200423PMC4869156W2293371096What OpenQuestion holds
Registered trials
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