ArticleScientifica2016
Modulation of Drug Resistance in Staphylococcus aureus with Coumarin Derivatives.
Article in Scientifica, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 32 citations in OpenAlex.
- Plant-Derived Antimicrobials and Their Crucial Role in Combating Antimicrobial Resistance.Antibiotics (Basel, Switzerland) · 2024Review
- Coumarin derivatives ameliorate the intestinal inflammation and pathogenic gut microbiome changes in the model of infectious colitis through antibacterial activity.Frontiers in cellular and infection microbiology · 2024Article
- 3-Substituted Coumarins Inhibit NorA and MepA Efflux Pumps ofAntibiotics (Basel, Switzerland) · 2023Article
- Coumarin-Encapsulated Solid Lipid Nanoparticles as an Effective Therapy against Methicillin-ResistantBioengineering (Basel, Switzerland) · 2022Article
- Preliminary Phytochemical Profile and Bioactivity ofPlants (Basel, Switzerland) · 2022Article
- Progress in Alternative Strategies to Combat Antimicrobial Resistance: Focus on Antibiotics.Antibiotics (Basel, Switzerland) · 2022Review
- Modulation of Drug Resistance by Furanochromones inEvidence-based complementary and alternative medicine : eCAM · 2022Article
- Plant Lectins: A Review on their Biotechnological Potential Toward Human Pathogens.Current protein & peptide science · 2022Review
- Tackling Multiple-Drug-Resistant Bacteria With Conventional and Complex Phytochemicals.Frontiers in cellular and infection microbiology · 2022Review
- Brief Overview of Approaches and Challenges in New Antibiotic Development: A Focus On Drug Repurposing.Frontiers in cellular and infection microbiology · 2021Review
- Challenges to antimicrobial susceptibility testing of plant-derived polyphenolic compounds.Arhiv za higijenu rada i toksikologiju · 2020Review
- An Updated Review on the Synthesis and Antibacterial Activity of Molecular Hybrids and Conjugates Bearing Imidazole Moiety.Molecules (Basel, Switzerland) · 2020Review
- Spiro-Indole-Coumarin Hybrids: Synthesis, ADME, DFT, NBO Studies and In Silico Screening through Molecular Docking on DNA G-Quadruplex.ChemistrySelect · 2020Article
- Development and Evaluation of Antimicrobial and Modulatory Activity of Inclusion Complex ofInternational journal of molecular sciences · 2020Article
- Preparation And Antibacterial Effects Of Carboxymethyl Chitosan-Modified Photo-ResponsiveInternational journal of nanomedicine · 2019Article
- Review on plant antimicrobials: a mechanistic viewpoint.Antimicrobial resistance and infection control · 2019Review
- Modulation of antimicrobial efflux pumps of the major facilitator superfamily inAIMS microbiology · 2018Review
- Synergism of Plant Compound With Traditional Antimicrobials AgainstFrontiers in microbiology · 2018Article
- Synthesis,Frontiers in chemistry · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Semisynthetic and commercial coumarins were investigated for their antibacterial and adjuvant properties with antibiotic agents against norfloxacin, erythromycin, and tetracycline resistant Staphylococcus aureus as based on efflux mechanisms. The coumarins and certain commercial antibiotics had their Minimum Inhibitory Concentrations determined by broth microdilution assay against resistant S. aureus strains which overexpress efflux pump proteins. For evaluation of the modulatory activity, the antibiotics MICs were determined in the presence of the coumarin derivatives at subinhibitory concentration. Although the coumarins did not display relevant antibacterial activity (MIC ≥ 128 µg/mL), they did modulate the antibiotics activities. Various coumarins, especially the alkylated derivatives in combination with antibiotics at subinhibitory concentrations, modulated antibiotic activity, reducing the MIC for tetracycline and norfloxacin by 2 to 8 times. Polar Surface Area (PSA) studies were performed and the fact that the presence of apolar groups is an important factor for the modulatory activity of coumarins was corroborated. Docking on the Penicillin-Binding Protein from MRSA identified that 18 is a potential ligand presenting low E binding. The results indicate that coumarin derivatives modulated antibiotic resistance and may be used as potential antibiotic adjuvants, acting by bacterial efflux pump inhibition in S. aureus.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.