Evidence map›Paper›PMID 27200098›Full record

ArticleEvidence-based complementary and alternative medicine : eCAM2016

Study on the Mechanism Underlying the Regulation of the NMDA Receptor Pathway in Spinal Dorsal Horns of Visceral Hypersensitivity Rats by Moxibustion.

L D Wang, J M Zhao, R J Huang, L Y Tan, Z H Hu, Z J Weng, K Wang, H G Wu, H R Liu

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Evidence-based complementary and alternative medicine : eCAM, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. P2X7 and P2YPurinergic signalling · 2025
    Article
  4. Electroacupuncture alleviates zymosan-induced colorectal hypersensitivity.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2025
    Article
  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

L D WangKey Laboratory of Acupuncture and Immunological Effects, Shanghai Research Institute of Acupuncture and Meridian, 650 South Wanping Road, Shanghai 200030, China.
J M ZhaoKey Laboratory of Acupuncture and Immunological Effects, Shanghai Research Institute of Acupuncture and Meridian, 650 South Wanping Road, Shanghai 200030, China.
R J HuangKey Laboratory of Acupuncture and Immunological Effects, Shanghai Research Institute of Acupuncture and Meridian, 650 South Wanping Road, Shanghai 200030, China.
L Y TanKey Laboratory of Acupuncture and Immunological Effects, Shanghai Research Institute of Acupuncture and Meridian, 650 South Wanping Road, Shanghai 200030, China.
Z H HuShanghai TCM-Integrated Hospital, Shanghai University of TCM, Shanghai 200082, China.
Z J WengKey Laboratory of Acupuncture and Immunological Effects, Shanghai Research Institute of Acupuncture and Meridian, 650 South Wanping Road, Shanghai 200030, China.
K WangKey Laboratory of Acupuncture and Immunological Effects, Shanghai Research Institute of Acupuncture and Meridian, 650 South Wanping Road, Shanghai 200030, China.
H G WuKey Laboratory of Acupuncture and Immunological Effects, Shanghai Research Institute of Acupuncture and Meridian, 650 South Wanping Road, Shanghai 200030, China.
H R LiuKey Laboratory of Acupuncture and Immunological Effects, Shanghai Research Institute of Acupuncture and Meridian, 650 South Wanping Road, Shanghai 200030, China.
Shanghai Research Center for Acupuncture and Meridians · CNShanghai University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Visceral hypersensitivity is enhanced in irritable bowel syndrome (IBS) patients. Treatment of IBS visceral pain by moxibustion methods has a long history and rich clinical experience. In the clinic, moxibustion on the Tianshu (ST25) and Shangjuxu (ST37) acupoints can effectively treat bowel disease with visceral pain and diarrhea symptoms. To investigate the regulatory function of moxibustion on the Tianshu (ST25) and Shangjuxu (ST37) acupoints on spinal cord NR1, NR2B, and PKCε protein and mRNA expression in irritable bowel syndrome (IBS) visceral hypersensitivity rats, we did some research. In the study, we found that moxibustion effectively relieved the IBS visceral hyperalgesia status of rats. Analgesic effect of moxibustion was similar to intrathecal injection of Ro 25-6981. The expression of NR1, NR2B, and PKCε in the spinal dorsal horns of IBS visceral hyperalgesia rats increased. Moxibustion on the Tianshu and Shangjuxu acupoints might inhibit the visceral hypersensitivity, simultaneously decreasing the expression of NR1, NR2B, and PKCε in spinal cord of IBS visceral hyperalgesia rats. Based on the above experimental results, we hypothesized NR1, NR2B, and PKCε of spinal cord could play an important role in moxibustion inhibiting the process of central sensitization and visceral hyperalgesia state.

Identifiers

PMID27200098
PMCPMC4855029
OpenAlexW2336230243

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.