ReviewFrontiers in plant science2016
In Search of Enzymes with a Role in 3', 5'-Cyclic Guanosine Monophosphate Metabolism in Plants.
Review in Frontiers in plant science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed, 53 citations in OpenAlex.
- Article
- Synthetic Small Molecules as Regulators of In Vitro Multiplication inPlants (Basel, Switzerland) · 2026Article
- Synergistic Effects of Polystyrene Nanoplastics and Cadmium on the Metabolic Processes and Their Accumulation in Hydroponically Grown Lettuce (Journal of agricultural and food chemistry · 2025Article
- Progress in Plant Nitric Oxide Studies: Implications for Phytopathology and Plant Protection.International journal of molecular sciences · 2025Review
- The role of statistics in advancing nitric oxide research in plant biology: from data analysis to mechanistic insights.Frontiers in plant science · 2025Review
- Metabolomics of early blight (Alternaria solani) susceptible tomato (Solanum lycopersicum) unfolds key biomarker metabolites and involved metabolic pathways.Scientific reports · 2023Article
- Signal Mediators in the Implementation of Jasmonic Acid's Protective Effect on Plants under Abiotic Stresses.Plants (Basel, Switzerland) · 2023Review
- The role of nitric oxide and hydrogen sulfide in regulation of redox homeostasis at extreme temperatures in plants.Frontiers in plant science · 2023Review
- Transcriptomics combined with metabolomics unveiled the key genes and metabolites of mycelium growth inFrontiers in microbiology · 2023Article
- Involvement of Calcium and Calmodulin in NO-Alleviated Salt Stress in Tomato Seedlings.Plants (Basel, Switzerland) · 2022Article
- Review
- Effects of Storage Temperature on Indica-Japonica Hybrid Rice Metabolites, Analyzed Using Liquid Chromatography and Mass Spectrometry.International journal of molecular sciences · 2022Article
- Tryptophan Levels as a Marker of Auxins and Nitric Oxide Signaling.Plants (Basel, Switzerland) · 2022Article
- Metabolic Insight into Cold Stress Response in Two Contrasting Maize Lines.Life (Basel, Switzerland) · 2022Article
- Genome-Wide Analysis and Characterization of the Proline-Rich Extensin-like Receptor Kinases (PERKs) Gene Family Reveals Their Role in Different Developmental Stages and Stress Conditions in Wheat (Plants (Basel, Switzerland) · 2022Article
- Metabolomics Insights into Chemical Convergence inMetabolites · 2021Article
- In Search of Monocot Phosphodiesterases: Identification of a Calmodulin Stimulated Phosphodiesterase fromInternational journal of molecular sciences · 2021Article
- Moonlighting Proteins Shine New Light on Molecular Signaling Niches.International journal of molecular sciences · 2021Review
- The Complex Story of Plant Cyclic Nucleotide-Gated Channels.International journal of molecular sciences · 2021Review
- A tandem motif-based and structural approach can identify hidden functional phosphodiesterases.Computational and structural biotechnology journal · 2021Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In plants, nitric oxide (NO)-mediated 3', 5'-cyclic guanosine monophosphate (cGMP) synthesis plays an important role during pathogenic stress response, stomata closure upon osmotic stress, the development of adventitious roots and transcript regulation. The NO-cGMP dependent pathway is well characterized in mammals. The binding of NO to soluble guanylate cyclase enzymes (GCs) initiates the synthesis of cGMP from guanosine triphosphate. The produced cGMP alters various cellular responses, such as the function of protein kinase activity, cyclic nucleotide gated ion channels and cGMP-regulated phosphodiesterases. The signal generated by the second messenger is terminated by 3', 5'-cyclic nucleotide phosphodiesterase (PDEs) enzymes that hydrolyze cGMP to a non-cyclic 5'-guanosine monophosphate. To date, no homologues of mammalian cGMP-synthesizing and degrading enzymes have been found in higher plants. In the last decade, six receptor proteins from Arabidopsis thaliana have been reported to have guanylate cyclase activity in vitro. Of the six receptors, one was shown to be a NO dependent guanylate cyclase enzyme (NOGC1). However, the role of these proteins in planta remains to be elucidated. Enzymes involved in the degradation of cGMP remain elusive, albeit, PDE activity has been detected in crude protein extracts from various plants. Additionally, several research groups have partially purified and characterized PDE enzymatic activity from crude protein extracts. In this review, we focus on presenting advances toward the identification of enzymes involved in the cGMP metabolism pathway in higher plants.
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