Evidence map›Paper›PMID 27199969›Full record

ReviewFrontiers in microbiology2016

The Microbiota and Health Promoting Characteristics of the Fermented Beverage Kefir.

Benjamin C T Bourrie, Benjamin P Willing, Paul D Cotter

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in Frontiers in microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06695221 (Improving Health Outcomes With Kefir), which is not on this map. Cited by 130 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
130citing papers in PubMed, 1 pooled it
34.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06695221 narecruitingnot on this mapstarted 2026, after this paper: background citation

Improving Health Outcomes With Kefir

TypeinterventionalSponsorUniversity of AlbertaRan2026 to 2027Enrolled156ConditionsSystemic Inflammatory Response, Diabetes Mellitus, Type 2, Cardiovascular DiseasesArmsTraditional Kefir, Milk (placebo)
3 · Its place in the literature

Who cites it

130 citing papers in PubMed, 1 synthesis or guideline pooled it, 413 citations in OpenAlex.

  1. The effects ofFrontiers in nutrition · 2025
    Pooled it
  2. Trial
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  6. Article
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  8. Multianalytical Characterization of Elderberry (Foods (Basel, Switzerland) · 2026
    Article
  9. Review
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  12. Review
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  14. Article
  15. Probiotics and Fermented Foods in Human Nutrition.Molecules (Basel, Switzerland) · 2026
    Review
  16. Article
  17. Review
  18. Review
  19. Article
  20. Article

70 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Benjamin C T BourrieAgricultural, Food and Nutritional Sciences, University of AlbertaEdmonton, AB, Canada; Teagasc Food Research CentreFermoy, Ireland.
Benjamin P WillingAgricultural, Food and Nutritional Sciences, University of Alberta Edmonton, AB, Canada.
Paul D CotterTeagasc Food Research CentreFermoy, Ireland; APC Microbiome InstituteCork, Ireland.
Teagasc - The Irish Agriculture and Food Development Authority · IEUniversity of Alberta · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Kefir is a complex fermented dairy product created through the symbiotic fermentation of milk by lactic acid bacteria and yeasts contained within an exopolysaccharide and protein complex called a kefir grain. As with other fermented dairy products, kefir has been associated with a range of health benefits such as cholesterol metabolism and angiotensin-converting enzyme (ACE) inhibition, antimicrobial activity, tumor suppression, increased speed of wound healing, and modulation of the immune system including the alleviation of allergy and asthma. These reports have led to increased interest in kefir as a focus of research and as a potential probiotic-containing product. Here, we review those studies with a particular emphasis on the microbial composition and the health benefits of the product, as well as discussing the further development of kefir as an important probiotic product.

Indexed as

fermented foodsgut microbiotaimmunomodulationkefirmetabolic diseases

Identifiers

PMID27199969
PMCPMC4854945
OpenAlexW2346157024

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.