ArticleFrontiers in microbiology2016
Antibacterial Effect of Copper on Microorganisms Isolated from Bovine Mastitis.
Article in Frontiers in microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed, 78 citations in OpenAlex.
- A Therapeutic Copper Hydrogel for Seborrheic Dermatitis: From Fungal Eradication to Skin Lesion Repair.Advanced healthcare materials · 2026Article
- Exploring the Therapeutic Potential of Essential Oils of the Valdivian Rainforest (Animals : an open access journal from MDPI · 2026Article
- Effects of copper stress on biofilm and capsule gene expression of Streptococcus agalactiae isolated from bovine mastitis.Archives of microbiology · 2025Article
- The importance of zinc, copper and manganese and their impact on growth, immunity and fertility of male cattle: a review.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2025Review
- The influence of trace metal supplementation on the presence of ceftriaxone resistance inMicrobiology spectrum · 2025Article
- Copper- and Zinc-Based Coordination Polymers toward the Development of More Efficient Agrochemicals.ACS omega · 2025Article
- Self-Healing Hydrogels with Intrinsic Antioxidant and Antibacterial Properties Based on Oxidized Hydroxybutanoyl Glycan and Quaternized Carboxymethyl Chitosan for pH-Responsive Drug Delivery.Gels (Basel, Switzerland) · 2025Article
- Analysis of pathogenic bacteria and antimicrobial residues in bovine waste milk on dairy farms in southern Chile.Frontiers in veterinary science · 2025Article
- Effects of a Dietary Multi-Mineral Bolus on Udder Health in Dairy Cows: A Clinical Assessment.Veterinary sciences · 2024Article
- Efficacy of Copper Ion Treatment on Bacteria and Antibiotic Residues Contained in Bovine Waste Milk.Antibiotics (Basel, Switzerland) · 2024Article
- Agricultural Mitigation Strategies to Reduce the Impact of Romaine Lettuce Contamination.Plants (Basel, Switzerland) · 2024Article
- Nutrition, gastrointestinal microorganisms and metabolites in mastitis occurrence and control.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2024Review
- Camel urine as a potential source of bioactive molecules showing their efficacy against pathogens: A systematic review.Saudi journal of biological sciences · 2024Review
- Enhanced healing of wounds that responded poorly to silver dressing by copper wound dressings: Prospective single arm treatment study.Health science reports · 2024Article
- Enhancing bovine immune, antioxidant and anti-inflammatory responses with vitamins, rumen-protected amino acids, and trace minerals to prevent periparturient mastitis.Frontiers in immunology · 2023Review
- Specific and non-specific effects ofFrontiers in veterinary science · 2023Article
- Antibacterial activity, cytocompatibility, and thermomechanical stability of TiMaterials today. Bio · 2022Article
- Inhibitory Effect againstFoods (Basel, Switzerland) · 2022Article
- Zeolite-Supported Aggregate as Potential Antimicrobial Agents in Gypsum Composites.Materials (Basel, Switzerland) · 2022Article
- A Ternary Copper (II) Complex with 4-Fluorophenoxyacetic Acid Hydrazide in Combination with Antibiotics Exhibits Positive Synergistic Effect againstAntibiotics (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The antimicrobial properties of copper have been recognized for several years; applying these properties to the prevention of diseases such as bovine mastitis is a new area of research. The aim of the present study was to evaluate in vitro the antimicrobial activity of copper on bacteria isolated from subclinical and clinical mastitis milk samples from two regions in Chile. A total of 327 microorganisms were recovered between March and September 2013, with different prevalence by sample origin (25 and 75% from the central and southern regions of Chile, respectively). In the central region, Escherichia coli and coagulase negative Staphylococci (CNS) were the most frequently detected in clinical mastitis cases (33%), while in the southern region S. uberis, S. aureus, and CNS were detected with frequencies of 22, 21, and 18%, respectively. Antibiotic susceptibility studies revealed that 34% of isolates were resistant to one or more antibiotics and the resistance profile was different between bacterial species and origins of isolation of the bacteria. The minimum inhibitory concentration of copper (MIC-Cu) was evaluated in all the isolates; results revealed that a concentration as low as 250 ppm copper was able to inhibit the great majority of microorganisms analyzed (65% of isolates). The remaining isolates showed a MIC-Cu between 375 and 700 ppm copper, and no growth was observed at 1000 ppm. A linear relationship was found between the logarithm of viable bacteria number and time of contact with copper. With the application of the same concentration of copper (250 ppm), CNS showed the highest tolerance to copper, followed by S. uberis and S. aureus; the least resistant was E. coli. Based on these in vitro results, copper preparations could represent a good alternative to dipping solutions, aimed at preventing the presence and multiplication of potentially pathogenic microorganisms involved in bovine mastitis disease.
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