ArticleFrontiers in microbiology2016
Resistance Assessment for Oxathiapiprolin in Phytophthora capsici and the Detection of a Point Mutation (G769W) in PcORP1 that Confers Resistance.
Article in Frontiers in microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25 citing papers in PubMed.
- Antagonistic Mechanisms ofPlants (Basel, Switzerland) · 2026Article
- Resistance risk asssement and molecular basis of metconazole in Fusarium pseudograminearum.Stress biology · 2025Article
- Novel application of ribonucleoprotein-mediated CRISPR-Cas9 gene editing in plant pathogenic oomycete species.Microbiology spectrum · 2025Article
- Phytophthora zoospores display klinokinetic behaviour in response to a chemoattractant.PLoS pathogens · 2024Article
- Deciphering fungicide resistance in Phytophthora: mechanisms, prevalence, and sustainable management approaches.World journal of microbiology & biotechnology · 2024Review
- Replacing Mancozeb with Alternative Fungicides for the Control of Late Blight in Potato.Journal of fungi (Basel, Switzerland) · 2023Article
- A slicing mechanism facilitates host entry by plant-pathogenic Phytophthora.Nature microbiology · 2021Article
- Biotechnological approaches in management of oomycetes diseases.3 Biotech · 2021Review
- Stepwise accumulation of mutations in CesA3 inEvolutionary applications · 2021Article
- Fantastic Downy Mildew Pathogens and How to Find Them: Advances in Detection and Diagnostics.Plants (Basel, Switzerland) · 2021Review
- Assessing the effectiveness of oxathiapiprolin towardFEMS microbes · 2021Article
- Effective control of two genotypes of Phytophthora infestans in the field by three oxathiapiprolin fungicidal mixtures.PloS one · 2021Article
- Polycystic Kidney Disease Ryanodine Receptor Domain (PKDRR) Proteins in Oomycetes.Pathogens (Basel, Switzerland) · 2020Article
- Synthesis and Evaluation of Novel Ellipticines and Derivatives as Inhibitors ofPathogens (Basel, Switzerland) · 2020Article
- Inhibitory Properties of Aldehydes and Related Compounds againstPathogens (Basel, Switzerland) · 2020Article
- Sensitivity of Different Developmental Stages and Resistance Risk Assessment ofFrontiers in microbiology · 2020Article
- A new strategy for durable control of late blight in potato by a single soil application of an oxathiapiprolin mixture in early season.PloS one · 2020Article
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- Novel synergistic fungicidal mixtures of oxathiapiprolin protect sunflower seeds from downy mildew caused by Plasmopara halstedii.PloS one · 2019Article
- Article
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Abstract
The potential for oxathiapiprolin resistance in Phytophthora capsici was evaluated. The baseline sensitivities of 175 isolates to oxathiapiprolin were initially determinated and found to conform to a unimodal curve with a mean EC50 value of 5.61 × 10(-4) μg/ml. Twelve stable oxathiapiprolin-resistant mutants were generated by fungicide adaptation in two sensitive isolates, LP3 and HNJZ10. The fitness of the LP3-mutants was found to be similar to or better than that of the parental isolate LP3, while the HNJZ10-mutants were found to have lost the capacity to produce zoospores. Taken together these results suggest that the risk of P. capsici developing resistance to oxathiapiprolin is moderate. Comparison of the PcORP1 genes in the LP3-mutants and wild-type parental isolate, which encode the target protein of oxathiapiprolin, revealed that a heterozygous mutation caused the amino acid substitution G769W. Transformation and expression of the mutated PcORP1-769W allele in the sensitive wild-type isolate BYA5 confirmed that the mutation in PcORP1 was responsible for the observed oxathiapiprolin resistance. Finally diagnostic tests including As-PCR and CAPs were developed to detect the oxathiapiprolin resistance resulting from the G769W point mutation in field populations of P. capsici.
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