ArticleFrontiers in microbiology2016
Spatial and Temporal Profiling of Griseofulvin Production in Xylaria cubensis Using Mass Spectrometry Mapping.
Article in Frontiers in microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 36 citations in OpenAlex.
- Mining the Hidden Pharmacopeia: Fungal Endophytes, Natural Products, and the Rise of AI-Driven Drug Discovery.International journal of molecular sciences · 2026Review
- Article
- Biopesticide Compounds from an Endolichenic FungusMolecules (Basel, Switzerland) · 2025Article
- Fungal-fungal co-culture: a primer for generating chemical diversity.Natural product reports · 2022Review
- Endophytic Fungi: Key Insights, Emerging Prospects, and Challenges in Natural Product Drug Discovery.Microorganisms · 2022Review
- Fungal Guttation, a Source of Bioactive Compounds, and Its Ecological Role-A Review.Biomolecules · 2021Review
- Drug Leads from Endophytic Fungi: Lessons Learned via Scaled Production.Planta medica · 2020Article
- Metabolomic-guided discovery of cyclic nonribosomal peptides from Xylaria ellisii sp. nov., a leaf and stem endophyte of Vaccinium angustifolium.Scientific reports · 2020Article
- Wheldone: Characterization of a Unique Scaffold from the Coculture ofOrganic letters · 2020Article
- Mass Spectrometry Guided Discovery and Design of Novel Asperphenamate Analogs FromFrontiers in microbiology · 2020Article
- Draft Genome Sequence of the Griseofulvin-Producing Fungus Xylaria flabelliformis Strain G536.Microbiology resource announcements · 2019Article
- Droplet probe: coupling chromatography to the in situ evaluation of the chemistry of nature.Natural product reports · 2019Review
- Mapping the Fungal Battlefield: UsingFrontiers in microbiology · 2019Article
- Media studies to enhance the production of verticillins facilitated by in situ chemical analysis.Journal of industrial microbiology & biotechnology · 2018Article
- Calothrixamides A and B from the Cultured Cyanobacterium Calothrix sp. UIC 10520.Journal of natural products · 2018Article
- Endophytic Fungi: A Source of Potential Antifungal Compounds.Journal of fungi (Basel, Switzerland) · 2018Review
- In situ mass spectrometry monitoring of fungal cultures led to the identification of four peptaibols with a rare threonine residue.Phytochemistry · 2017Article
- qNMR for profiling the production of fungal secondary metabolites.Magnetic resonance in chemistry : MRC · 2017Article
- Secondary metabolites of endophytic Xylaria species with potential applications in medicine and agriculture.World journal of microbiology & biotechnology · 2017Review
- Prealamethicin F50 and related peptaibols fromRSC advances · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A large portion of natural products research revolves around the discovery of new, bioactive chemical entities; however, studies to probe the biological purpose of such secondary metabolites for the host organism are often limited. Mass spectrometry mapping of secondary metabolite biosynthesis in situ can be used to probe a series of ecological questions about fungi that may be lost through traditional natural products chemistry extraction protocols. A griseofulvin-producing fungal culture of the Xylariaceae family, isolated as an endophyte of the tree Asimina triloba, was analyzed through a series of spatial and temporal mapping experiments. This fungus produced unique fungal characteristics, such as guttates and stroma, both of which were explored spatially. The distribution of griseofulvin on this culture in isolation was compared to its dispersal when grown in co-culture with a competing Penicillium species via a droplet-based surface sampling system. The fungistatic properties of griseofulvin were visualized, including the consequences for biosynthesis of polyhydroxyanthraquinones in a rival culture.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.