Evidence map›Paper›PMID 27199769›Full record

ArticleFrontiers in physiology2016

Heritability of ECG Biomarkers in the Netherlands Twin Registry Measured from Holter ECGs.

Emily C Hodkinson, Melanie Neijts, Arash Sadrieh, Mohammad S Imtiaz, Mathias Baumert, Rajesh N Subbiah, Christopher S Hayward, Dorret Boomsma, Gonneke Willemsen, Jamie I Vandenberg and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 3 pooled it
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 3 syntheses or guidelines pooled it, 12 citations in OpenAlex.

  1. The diagnostic role of T wave morphology biomarkers in congenital and acquired long QT syndrome: A systematic review.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2023
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Observational
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  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Emily C HodkinsonMolecular Cardiology and Biophysics, Victor Chang Cardiac Research InstituteDarlinghurst, NSW, Australia; St Vincent's Clinical School, University of New South WalesSydney, NSW, Australia.
Melanie NeijtsDepartment of Biological Psychology, EMGO+ Institute, VU University and VU Medical Center Amsterdam, Netherlands.
Arash SadriehMolecular Cardiology and Biophysics, Victor Chang Cardiac Research InstituteDarlinghurst, NSW, Australia; St Vincent's Clinical School, University of New South WalesSydney, NSW, Australia.
Mohammad S ImtiazMolecular Cardiology and Biophysics, Victor Chang Cardiac Research InstituteDarlinghurst, NSW, Australia; St Vincent's Clinical School, University of New South WalesSydney, NSW, Australia.
Mathias BaumertSchool of Electrical and Electronic Engineering, University of Adelaide Adelaide, SA, Australia.
Rajesh N SubbiahSt Vincent's Clinical School, University of New South Wales Sydney, NSW, Australia.
Christopher S HaywardSt Vincent's Clinical School, University of New South Wales Sydney, NSW, Australia.
Dorret BoomsmaDepartment of Biological Psychology, EMGO+ Institute, VU University and VU Medical Center Amsterdam, Netherlands.
Gonneke WillemsenDepartment of Biological Psychology, EMGO+ Institute, VU University and VU Medical Center Amsterdam, Netherlands.
Jamie I VandenbergMolecular Cardiology and Biophysics, Victor Chang Cardiac Research InstituteDarlinghurst, NSW, Australia; St Vincent's Clinical School, University of New South WalesSydney, NSW, Australia.
Adam P HillMolecular Cardiology and Biophysics, Victor Chang Cardiac Research InstituteDarlinghurst, NSW, Australia; St Vincent's Clinical School, University of New South WalesSydney, NSW, Australia.
Eco De GeusDepartment of Biological Psychology, EMGO+ Institute, VU University and VU Medical Center Amsterdam, Netherlands.
Amsterdam UMC Location VUmc · NLUNSW Sydney · AUVictor Chang Cardiac Research Institute · AUSt Vincent's Clinic · AUUniversity of Adelaide · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe resting ECG is the most commonly used tool to assess cardiac electrophysiology. Previous studies have estimated heritability of ECG parameters based on these snapshots of the cardiac electrical activity. In this study we set out to determine whether analysis of heart rate specific data from Holter ECGs allows more complete assessment of the heritability of ECG parameters. METHODS AND

resultsHolter ECGs were recorded from 221 twin pairs and analyzed using a multi-parameter beat binning approach. Heart rate dependent estimates of heritability for QRS duration, QT interval, Tpeak-Tend and Theight were calculated using structural equation modeling. QRS duration is largely determined by environmental factors whereas repolarization is primarily genetically determined. Heritability estimates of both QT interval and Theight were significantly higher when measured from Holter compared to resting ECGs and the heritability estimate of each was heart rate dependent. Analysis of the genetic contribution to correlation between repolarization parameters demonstrated that covariance of individual ECG parameters at different heart rates overlap but at each specific heart rate there was relatively little overlap in the genetic determinants of the different repolarization parameters.

conclusionsHere we present the first study of heritability of repolarization parameters measured from Holter ECGs. Our data demonstrate that higher heritability can be estimated from the Holter than the resting ECG and reveals rate dependence in the genetic-environmental determinants of the ECG that has not previously been tractable. Future applications include deeper dissection of the ECG of participants with inherited cardiac electrical disease.

Indexed as

ECGheritabilityHolter electrocardiogramhuman geneticstwins

Identifiers

PMID27199769
PMCPMC4850154
OpenAlexW2344266236

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.