ArticleFrontiers in physiology2016
Toxic Effects of Zinc Chloride on the Bone Development in Danio rerio (Hamilton, 1822).
Article in Frontiers in physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 67 citations in OpenAlex.
- Antibiotic Resistance Genes in Klebsiella pneumoniae and Heavy Metal Contamination in Tilapia (Oreochromis niloticus): A Public Health Risk Assessment in Bangladesh.Veterinary medicine and science · 2026Article
- Metal(oid) profiling of the common site of osteoporotic fractures with bone microarchitecture correlation analysis: a comparative study of hip fracture patients and healthy individuals.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2025Article
- Ovary of Zebrafish during Spawning Season: Ultrastructure and Immunohistochemical Profiles of Sox9 and Myostatin.Animals : an open access journal from MDPI · 2023Article
- Review
- Copper and Zinc Treatments Alter the Thyroid Endocrine System in Zebrafish Embryos/Larvae.Toxics · 2022Article
- Article
- Study of the Mandibular Bone Microstructure and Blood Minerals Bioavailability in Rainbow Trout (Animals : an open access journal from MDPI · 2022Article
- Interference with zinc homeostasis and oxidative stress induction as probable mechanisms for cadmium-induced embryo-toxicity in zebrafish.Environmental science and pollution research international · 2022Article
- Impacts of heavy metals on early development, growth and reproduction of fish - A review.Toxicology reports · 2022Review
- Survival of Embryos and Fry of Sea Trout (Animals : an open access journal from MDPI · 2021Article
- A Systematic Analysis of Metal and Metalloid Concentrations in Eight Zebrafish Recirculating Water Systems.Zebrafish · 2021Article
- Learning by Doing: The Use of Distance, Corners and Length in Rewarded Geometric Tasks by Zebrafish (Animals : an open access journal from MDPI · 2021Article
- Oocyte Ageing in ZebrafishAnimals : an open access journal from MDPI · 2021Article
- Effect of salinity on zinc toxicity (ZnClEnvironmental science and pollution research international · 2020Article
- Effect of Zinc onToxins · 2020Article
- Zinc Chloride Exposure Inhibits Brain Acetylcholine Levels, Produces Neurotoxic Signatures, and Diminishes Memory and Motor Activities in Adult Zebrafish.International journal of molecular sciences · 2018Article
- Differential Toxicity of mDia Formin-Directed Functional Agonists and Antagonists in Developing Zebrafish.Frontiers in pharmacology · 2018Article
- Screening in larval zebrafish reveals tissue-specific distribution of fifteen fluorescent compounds.Disease models & mechanisms · 2017Article
- Toxicity Evaluation of Graphene Oxide and Titania Loaded Nafion Membranes in Zebrafish.Frontiers in physiology · 2017Article
- Evaluation of Chronic Nanosilver Toxicity to Adult Zebrafish.Frontiers in physiology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The increase of heavy metals in the environment involves a high exposure of aquatic organisms to these pollutants. The present study is planned to investigate the effects of zinc chloride (ZnCl2) on the bone embryonic development of Danio rerio and confirm the use of zebrafish as a model organism to study the teratogenic potential of this pollutant. Zebrafish embryos were exposed to different ZnCl2 concentrations and analyzed by ICP-MS. The skeletal anomalies were evaluated to confocal microscope after staining with calcein solution and RhodZin(TM)-3,AM. The data show a delay in hatching compared with the controls, malformations in the process of calcification and significant defects in growth. In conclusion, the current work demonstrates for the first time the Zn toxic effects on calcification process and confirm zebrafish (Danio rerio) as suitable alternative vertebrate model to study the causes and the mechanisms of the skeletal malformations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.