ArticleFrontiers in pharmacology2016
Metagenomic Analysis of Antibiotic-Induced Changes in Gut Microbiota in a Pregnant Rat Model.
Article in Frontiers in pharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Maternal Metformin Exposure Induces Gut Microbial Shifts in Non-Diabetic Dams and Sex-Stratified Changes in Mouse Offspring.Biomolecules · 2026Article
- A Review of Gut Microbiota Dynamics: From Healthy Gestation to Gestational Diabetes in Human and Mouse Models.Biomedicines · 2026Review
- Biomaterials mediated 3R (remove-remodel-repair) strategy: holistic management of Helicobacter pylori infection.Journal of nanobiotechnology · 2025Review
- Dynamic Changes in the Gut Microbiota During Peripartum in Jennies.Animals : an open access journal from MDPI · 2025Article
- Leveraging the role of the microbiome in endometriosis: novel non-invasive and therapeutic approaches.Frontiers in immunology · 2025Review
- Physiological function of gut microbiota and metabolome on successful pregnancy and lactation in the captive Yangtze finless porpoise (Neophocaena asiaeorientalis asiaeorientalis)†.Biology of reproduction · 2024Article
- Antibiotic alters host's gut microbiota, fertility, and antimicrobial peptide gene expression vis-à-vis ampicillin treatment on model organism Drosophila melanogaster.International microbiology : the official journal of the Spanish Society for Microbiology · 2024Article
- Alcohol consumption during pregnancy differentially affects the fecal microbiota of dams and offspring.Scientific reports · 2024Article
- An altered gut microbiome in pre-eclampsia: cause or consequence.Frontiers in cellular and infection microbiology · 2024Review
- Maternal antibiotic exposure and childhood allergies: The Japan Environment and Children's Study.The journal of allergy and clinical immunology. Global · 2023Article
- Gut Microbiota Composition in the First and Third Trimester of Pregnancy among Malay Women is Associated with Body Mass Index: A Pilot Study.The Malaysian journal of medical sciences : MJMS · 2023Article
- Early life adverse exposures in irritable bowel syndrome: new insights and opportunities.Frontiers in pediatrics · 2023Review
- Microbiota and nutrition as risk and resiliency factors following prenatal alcohol exposure.Frontiers in neuroscience · 2023Review
- 16S rRNA Gene Sequencing Revealed Changes in Gut Microbiota Composition during Pregnancy and Lactation in Mice Model.Veterinary sciences · 2022Article
- Dynamic alterations in the donkey fecal bacteria community and metabolome characteristics during gestation.Frontiers in microbiology · 2022Article
- Alterations in the gut microbiome and metabolic profile in rats acclimated to high environmental temperature.Microbial biotechnology · 2022Article
- The effect of different combinations of antibiotic cocktails on mice and selection of animal models for further microbiota research.Applied microbiology and biotechnology · 2021Article
- Variation of Gut Microbiome in Free-Ranging Female Tibetan Macaques (Animals : an open access journal from MDPI · 2020Article
- Maternal Microbiome and Infections in Pregnancy.Microorganisms · 2020Review
- Assessing the ocular surface microbiome in severe ocular surface diseases.The ocular surface · 2020Observational
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Food and Drug Administration (FDA, USA)-approved category B antibiotics are commonly prescribed to treat infections during pregnancy. The aim of this study was to investigate antibiotic-induced changes in gut microbiota (GM) that occur during pregnancy. The 16S rRNA amplicon deep-sequencing method was used to analyze the effect of category B antibiotics (azithromycin, amoxicillin and cefaclor) on GM during pregnancy using a rat model. The GM composition was substantially modulated by pregnancy and antibiotics administration. Firmicutes, Bacteroidetes, Proteobacteria, Chlamydiae, Actinobacteria, and Cyanobacteria were the dominant phyla. Antibiotic treatment during pregnancy increased the relative abundance of Proteobacteria and reduced Firmicutes. The genera Shigella, Streptococcus, Candidatus Arthromitus, and Helicobacter were significantly (p < 0.05) more abundant during pregnancy. Antibiotics significantly (p < 0.05) reduced the relative abundance of Lactobacillus but increased that of Enterobacter. There was a significant (p < 0.05) decrease in Lactobacillus sp., Lactobacillus gallinarum and Lactobacillus crispatus during pregnancy. Antibiotic treatment reduced bacterial diversity; the lowest number of operational taxonomic units (OTUs) were detected in the cefaclor-treated groups. Antibiotics significantly (p < 0.05) promoted weight gain during pregnancy, and increased relative abundance of Shigella sonnei, Enterococcus hormaechei, and Acinetobacter sp. GM perturbations were accompanied by increases in Proteobacteria abundance and weight gain in pregnancy following antibiotic treatment.
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