ReviewFrontiers in neural circuits2016
Inhibitory Circuits in Cortical Layer 5.
Review in Frontiers in neural circuits, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers.
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Who cites it
86 citing papers in PubMed.
- Decoding the Neural Circuit Underlying Context-Cue Association in Retrieval of Morphine Reward Memory.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Imbalance in excitation and inhibition in sgACC is associated with depression in dementia with Lewy bodies.Translational psychiatry · 2026Article
- Noise-invariant representations of sound emerge along the canonical cortical hierarchy.PLoS biology · 2026Article
- Somatosensory input drives membrane potential dynamics in motor cortex during voluntary limb movement.PLoS biology · 2026Article
- Sexually dimorphic plasticity of PV inhibition in sensory neocortex during learning.Scientific reports · 2026Article
- Functional KCC2 expression marks an evolutionarily conserved population of early-maturing interneurons in the perinatal cortex.Nature communications · 2025Article
- Alcohol Withdrawal Alters the Inhibitory Landscape of the Prelimbic Cortex in an Interneuron- and Sex-specific Manner.Addiction neuroscience · 2025Article
- A whole-brain male mouse atlas of long-range inputs to histaminergic neurons.Nature communications · 2025Article
- Enhanced beta power emerges from simulated parkinsonian primary motor cortex.NPJ Parkinson's disease · 2025Article
- The synaptic architecture of layer 5 thick tufted excitatory neurons in mouse visual cortex.Nature neuroscience · 2025Article
- Enhanced beta power emerges from simulated parkinsonian primary motor cortex.bioRxiv : the preprint server for biology · 2025Article
- Synergistic deficits in parvalbumin interneurons and dopamine signaling drive ACC dysfunction in chronic pain.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- A burst-dependent thalamocortical substrate for perceptual awareness.PLoS computational biology · 2025Article
- Article
- Effects of dendritic CaJournal of computational neuroscience · 2025Article
- Self-organized and self-sustained ensemble activity patterns in simulation of mouse primary motor cortex.bioRxiv : the preprint server for biology · 2025Article
- Fxr1 Deletion from Cortical Parvalbumin Interneurons Modifies Their Excitatory Synaptic Responses.eNeuro · 2025Article
- Focal postnatal deletion ofFrontiers in molecular neuroscience · 2025Article
- Article
- Cell-type-specific enhancement of deviance detection by synaptic zinc in the mouse auditory cortex.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
26 more citing papers are in PubMed but not listed here.
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Authors and funding
2 authors.
Funding
Abstract
Inhibitory neurons play a fundamental role in cortical computation and behavior. Recent technological advances, such as two photon imaging, targeted in vivo recording, and molecular profiling, have improved our understanding of the function and diversity of cortical interneurons, but for technical reasons most work has been directed towards inhibitory neurons in the superficial cortical layers. Here we review current knowledge specifically on layer 5 (L5) inhibitory microcircuits, which play a critical role in controlling cortical output. We focus on recent work from the well-studied rodent barrel cortex, but also draw on evidence from studies in primary visual cortex and other cortical areas. The diversity of both deep inhibitory neurons and their pyramidal cell targets make this a challenging but essential area of study in cortical computation and sensory processing.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.