ReviewFrontiers in cellular neuroscience2016
Potentiation of Gamma Aminobutyric Acid Receptors (GABAAR) by Ethanol: How Are Inhibitory Receptors Affected?
Review in Frontiers in cellular neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 63 citations in OpenAlex.
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- Comparative Efficacy of Acupuncture Therapy in Primary Essential Tremor: A Network Meta-Analysis and Systematic Review.Healthcare (Basel, Switzerland) · 2026Review
- Prenatal alcohol exposure perturbs the development of radial glial cells in the fetal olfactory bulb.Alcohol, clinical & experimental research · 2025Article
- A pilot exploratory study for analysis of clinical features and plasma catecholamines in blepharospasm.Scientific reports · 2025Article
- Association Between GABRG2 and Self-Rating of the Effects of Alcohol in a French Young Adult Sample.Risk management and healthcare policy · 2025Article
- Cx43 hemichannels and panx1 channels contribute to ethanol-induced astrocyte dysfunction and damage.Biological research · 2024Article
- Mutation of novel ethanol-responsive lncRNA Gm41261 impacts ethanol-related behavioral responses in mice.Genes, brain, and behavior · 2024Article
- Article
- Sexual Violence and Alcohol Intake: A Population-Based Explorative Study in a Northwestern Italian Area.Medicina (Kaunas, Lithuania) · 2023Article
- GABANeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023Article
- The Evolution Toward Designer Benzodiazepines in Drug-Facilitated Sexual Assault Cases.Journal of analytical toxicology · 2023Review
- The pathogenesis of blepharospasm.Frontiers in neurology · 2023Review
- Blood Vessels as a Key Mediator for Ethanol Toxicity: Implication for Neuronal Damage.Life (Basel, Switzerland) · 2022Review
- Functional Alternatives to Alcohol.Nutrients · 2022Review
- Systemic administration of racemic baclofen reduces both acquisition and maintenance of alcohol consumption in male and female mice.Alcohol (Fayetteville, N.Y.) · 2022Article
- GABAMolecules (Basel, Switzerland) · 2021Article
- The Aging GABAergic System and Its Nutritional Support.Journal of nutrition and metabolism · 2021Review
- Role of Hippocampal Neurogenesis in Alcohol Withdrawal Seizures.Brain plasticity (Amsterdam, Netherlands) · 2020Review
- Differential effects of ethanol on behavior and GABAScientific reports · 2020Article
- Sex Differences in the Expression of the α5 Subunit of the GABAAlcoholism, clinical and experimental research · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
In recent years there has been an increase in the understanding of ethanol actions on the type A γ-aminobutyric acid chloride channel (GABAAR), a member of the pentameric ligand gated ion channels (pLGICs). However, the mechanism by which ethanol potentiates the complex is still not fully understood and a number of publications have shown contradictory results. Thus many questions still remain unresolved requiring further studies for a better comprehension of this effect. The present review concentrates on the involvement of GABAAR in the acute actions of ethanol and specifically focuses on the immediate, direct or indirect, synaptic and extra-synaptic modulatory effects. To elaborate on the immediate, direct modulation of GABAAR by acute ethanol exposure, electrophysiological studies investigating the importance of different subunits, and data from receptor mutants will be examined. We will also discuss the nature of the putative binding sites for ethanol based on structural data obtained from other members of the pLGICs family. Finally, we will briefly highlight the glycine gated chloride channel (GlyR), another member of the pLGIC family, as a suitable target for the development of new pharmacological tools.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.