Evidence map›Paper›PMID 27199663›Full record

ReviewFrontiers in cellular neuroscience2016

Extracellular Vesicles in Physiology, Pathology, and Therapy of the Immune and Central Nervous System, with Focus on Extracellular Vesicles Derived from Mesenchymal Stem Cells as Therapeutic Tools.

Sylwia Koniusz, Anna Andrzejewska, Maurizio Muraca, Amit K Srivastava, Miroslaw Janowski, Barbara Lukomska

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in cellular neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 116 papers.

0numbers the graph read from it
0cells of the map it votes in
116citing papers in PubMed
11.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

116 citing papers in PubMed, 183 citations in OpenAlex.

  1. Article
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  6. FeBioengineering (Basel, Switzerland) · 2026
    Article
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  11. Osteogenic Effects of Brown AlgaePreventive nutrition and food science · 2025
    Article
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56 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 3 countries.

Sylwia KoniuszNeuroRepair Department, Mossakowski Medical Research Centre, Polish Academy of Sciences Warsaw, Poland.
Anna AndrzejewskaNeuroRepair Department, Mossakowski Medical Research Centre, Polish Academy of Sciences Warsaw, Poland.
Maurizio MuracaDepartment of Women's and Children's Health, University of Padua Padua, Italy.
Amit K SrivastavaRussel H. Morgan Department of Radiology and Radiological Science, Division of MR Research, The Johns Hopkins University School of Medicine, Baltimore MD, USA.
Miroslaw JanowskiNeuroRepair Department, Mossakowski Medical Research Centre, Polish Academy of SciencesWarsaw, Poland; Russel H. Morgan Department of Radiology and Radiological Science, Division of MR Research, The Johns Hopkins University School of Medicine, BaltimoreMD, USA.
Barbara LukomskaNeuroRepair Department, Mossakowski Medical Research Centre, Polish Academy of Sciences Warsaw, Poland.
Johns Hopkins University · USMossakowski Medical Research Institute, Polish Academy of Sciences · PLPolish Academy of Sciences · PLUniversity of Padua · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extracellular vesicles (EVs) are membrane-surrounded structures released by most cell types. They are characterized by a specific set of proteins, lipids and nucleic acids. EVs have been recognized as potent vehicles of intercellular communication to transmit biological signals between cells. In addition, pathophysiological roles of EVs in conditions like cancer, infectious diseases and neurodegenerative disorders are well established. In recent years focus has been shifted on therapeutic use of stem cell derived-EVs. Use of stem cell derived-EVs present distinct advantage over the whole stem cells as EVs do not replicate and after intravenous administration, they are less likely to trap inside the lungs. From the therapeutic perspective, the most promising cellular sources of EVs are mesenchymal stem cells (MSCs), which are easy to obtain and maintain. Therapeutic activity of MSCs has been shown in numerous animal models and the beneficial paracrine effect of MSCs may be mediated by EVs. The various components of MSC derived-EVs such as proteins, lipids, and RNA might play a specific therapeutic role. In this review, we characterize the role of EVs in immune and central nervous system (CNS); present evidences for defective signaling of these vesicles in neurodegeneration and therapeutic role of EVs in CNS.

Indexed as

biomarkersCNSextracellular vesiclesmesenchymal stromal cellsneurological diseasestransplantation

Identifiers

PMID27199663
PMCPMC4852177
OpenAlexW2345269382

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.