Evidence map›Paper›PMID 27199634›Full record

ArticleFrontiers in neuroscience2016

The International Deep Brain Stimulation Registry and Database for Gilles de la Tourette Syndrome: How Does It Work?

Wissam Deeb, Peter J Rossi, Mauro Porta, Veerle Visser-Vandewalle, Domenico Servello, Peter Silburn, Terry Coyne, James F Leckman, Thomas Foltynie, Marwan Hariz and 37 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
13.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.

  1. Pooled it
  2. The CM-aGPi Network in the Generation of Tics in Tourette Syndrome.Movement disorders : official journal of the Movement Disorder Society · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Basal Ganglia Pathways Associated With Therapeutic Pallidal Deep Brain Stimulation for Tourette Syndrome.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2021
    Article
  13. Review
  14. Deep brain stimulation for Tourette's syndrome.Translational neurodegeneration · 2020
    Review
  15. Article
  16. Article
  17. Neuroethics of Neuromodulation: An Update.Current opinion in biomedical engineering · 2018
    Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

47 authors at 20 institutions in 11 countries.

Wissam DeebDepartment of Neurology, University of Florida and Center for Movement Disorders and Neurorestoration Gainesville, FL, USA.
Peter J RossiDepartment of Neurology, University of Florida and Center for Movement Disorders and Neurorestoration Gainesville, FL, USA.
Mauro PortaTourette's Syndrome and Movement Disorders Center, Galeazzi Hospital Milan, Italy.
Veerle Visser-VandewalleDepartment of Stereotactic and Functional Neurosurgery, University of Cologne Cologne, Germany.
Domenico ServelloNeusurgical Department, IRCCS Galeazzi Milan, Italy.
Peter SilburnAsia-Pacific Centre for Neuromodulation, Queensland Brain InstituteBrisbane, Queensland, Australia; University of Queensland Centre for Clinical Research, The University of QueenslandBrisbane, Queensland, Australia.
Terry CoyneUniversity of Queensland Centre for Clinical Research, The University of QueenslandBrisbane, Queensland, Australia; BrizBrain&SpineBrisbane, QLD, Australia.
James F LeckmanDepartments of Psychiatry, Pediatrics and Psychology, Child Study Center, Yale University New Haven, CT, USA.
Thomas FoltynieSobell Department of Motor Neuroscience, University College London Institute of Neurology London, UK.
Marwan HarizSobell Department of Motor Neuroscience, University College London Institute of Neurology London, UK.
Eileen M JoyceSobell Department of Motor Neuroscience, University College London Institute of Neurology London, UK.
Ludvic ZrinzoSobell Department of Motor Neuroscience, University College London Institute of Neurology London, UK.
Zinovia KefalopoulouSobell Department of Motor Neuroscience, University College London Institute of Neurology London, UK.
Marie-Laure WelterAssistance publique - Hôpitaux de Paris, Institut du Cerveau et de la Moelle Epiniere, Institut National de la Santé et de la Recherche Médicale 1127, Pitié-Salpêtrière Hospital, Sorbonne Universités, UPMC Univ Paris 06, Unité Mixte de Recherche 1127, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 7225 Paris, France.
Carine KarachiInstitut National de la Santé et de la Recherche Médicale U 1127, Centre National de la Recherche Scientifique UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Institut du Cerveau et de la Moelle épinièreParis, France; Department of Neurosurgery, Assistance Publique - Hôpitaux de Paris, Hôpital de la Pitié-SalpêtrièreParis, France.
Luc MalletInstitut National de la Santé et de la Recherche Médicale U 1127, Centre National de la Recherche Scientifique UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Institut du Cerveau et de la Moelle épinièreParis, France; Assistance publique - Hôpitaux de Paris, DHU Pe-PSY, Pôle de Psychiatrie et d'addictologie des Hôpitaux Universitaires H Mondor, Université Paris Est CréteilCréteil, France; Department of Mental Health and Psychiatry, Geneva University HospitalGeneva, Switzerland.
Jean-Luc HouetoService de Neurologie, Institut National de la Santé et de la Recherche Médicale-Centres d'Investigation Clinique 1402, Centre Hospitalier Universitaire de Grenoble de Poitiers, Université de Poitiers Poitiers, France.
Joohi Shahed-JimenezParkinson's Disease Center and Movement Disorders Clinic, Baylor College of Medicine Houston, TX, USA.
Fan-Gang MengBeijing Neurosurgical Institute, Capital Medical University Beijing, China.
Bryan T KlassenDepartment of Neurology, Mayo Clinic College of Medicine Rochester, MN, USA.
Alon Y MogilnerDepartment of Neurosurgery, Center for Neuromodulation, NYU Langone Medical Center New York, NY, USA.
Michael H PourfarDepartment of Neurosurgery, Center for Neuromodulation, NYU Langone Medical Center New York, NY, USA.
Jens KuhnDepartment of Psychiatry and Psychotherapy, University of Cologne Cologne, Germany.
L AckermansDepartment of Neurosurgery, Maastricht University Medical Centre Maastricht, Netherlands.
Takanobu KaidoDepartment of Neurosurgery, National Center Hospital, National Center of Neurology and Psychiatry Kodaira, Japan.
Yasin TemelDepartment of Neurosurgery, Maastricht University Medical CenterMaastricht, Netherlands; Faculty of Health, Medicine and Life Sciences, School for Mental Health and Neuroscience, Maastricht UniversityMaastricht, Netherlands.
Robert E GrossDepartment of Neurosurgery, Emory University Atlanta, GA, USA.
Harrison C WalkerDepartment of Neurology, Department of Biomedical Engineering, University of Alabama at Birmingham Birmingham, AL, USA.
Andres M LozanoDivision of Neurosurgery, University of Toronto Toronto, Canada.
Suketu M KhandharDepartment of Neurology, The Permanente Medical Group (Tidewater Physicians Multispecialty Group), Movement Disorders Program Sacramento, CA, USA.
Benjamin L WalterUniversity Hospitals, Case Western Reserve University School of Medicine Cleveland, OH, USA.
Ellen WalterDepartment of Neurology, University Hospitals Case Medical Center, Neurological Institute Cleveland, OH, USA.
Zoltan MariParkinson's & Movement Disorder Center/Division, Johns Hopkins University, School of Medicine Baltimore, MD, USA.
Barbara K ChangiziDepartment of Neurology, The Ohio State University Wexner Medical Center Columbus, OH, USA.
Elena MoroDivision of Neurology, Centre Hospitalier Universitaire de Grenoble Grenoble, Grenoble Alpes University Grenoble, France.
Juan C BaldermannDepartment of Psychiatry and Psychotherapy, Universitätsklinikum Köln Köln, Germany.
Daniel HuysDepartment of Psychiatry and Psychotherapy, Universitätsklinikum Köln Köln, Germany.
S Elizabeth ZauberDepartment of Neurology, Indiana University School of Medicine Indianapolis, IN, USA.
Lauren E SchrockDepartment of Neurology, University of Utah Salt Lake City, UT, USA.
Jian-Guo ZhangDepartment of Functional Neurosurgery, Beijing Tiantan Hospital, Capital Medical University Beijing, China.
Wei HuDepartment of Neurology, University of Florida and Center for Movement Disorders and Neurorestoration Gainesville, FL, USA.
Kelly D FooteDepartment of Neurology, University of Florida and Center for Movement Disorders and NeurorestorationGainesville, FL, USA; Department of Neurological Surgery, University of FloridaGainesville, FL, USA.
Kyle RizerDepartment of Neurology, University of Florida and Center for Movement Disorders and Neurorestoration Gainesville, FL, USA.
Jonathan W MinkDepartment of Neurology, University of Rochester Medical Center Rochester, NY, USA.
Douglas W WoodsDepartment of Psychology, Marquette University Milwaukee, WI, USA.
Aysegul GunduzDepartment of Neurology, University of Florida and Center for Movement Disorders and NeurorestorationGainesville, FL, USA; J. Crayton Pruitt Family Department of Biomedical Engineering, University of FloridaGainesville, FL, USA.
Michael S OkunDepartment of Neurology, University of Florida and Center for Movement Disorders and Neurorestoration Gainesville, FL, USA.
University of Florida · USUniversity College London · GBNYU Langone Health · USUniversity of Cologne · DEAssistance Publique – Hôpitaux de Paris · FRBaylor College of Medicine · USBeijing Institute of Neurosurgery · CNCapital Medical University · CNCase Western Reserve University · USCentre Hospitalier Universitaire de Grenoble · FRCentre Hospitalier Universitaire de Poitiers · FRCentrum für Integrierte Onkologie · DEEmory University · USIndiana University – Purdue University Indianapolis · USInserm · FRIstituto Ortopedico Galeazzi · ITJohns Hopkins University · USMaastricht University · NLMaastricht University Medical Centre · NLMarquette University · US

Funding

Training In Rehabilitation and Neuromuscular PlasticityT32HD043730 · NICHD · UNIVERSITY OF FLORIDA · PI DAVID D FULLER · 2003 to 2026
$5.3M
Mobile Decision Support System for Nurse Management of Neuromodulation TherapyR01NR014852 · NINR · UNIVERSITY OF UTAH · PI BUTSON, CHRISTOPHER R, OKUN, MICHAEL S · 2015 to 2019
$2.9M
NICHD NIH HHS T32 HD043730NINR NIH HHS R01 NR014852
6 · The paper itself

Abstract

Tourette Syndrome (TS) is a neuropsychiatric disease characterized by a combination of motor and vocal tics. Deep brain stimulation (DBS), already widely utilized for Parkinson's disease and other movement disorders, is an emerging therapy for select and severe cases of TS that are resistant to medication and behavioral therapy. Over the last two decades, DBS has been used experimentally to manage severe TS cases. The results of case reports and small case series have been variable but in general positive. The reported interventions have, however, been variable, and there remain non-standardized selection criteria, various brain targets, differences in hardware, as well as variability in the programming parameters utilized. DBS centers perform only a handful of TS DBS cases each year, making large-scale outcomes difficult to study and to interpret. These limitations, coupled with the variable effect of surgery, and the overall small numbers of TS patients with DBS worldwide, have delayed regulatory agency approval (e.g., FDA and equivalent agencies around the world). The Tourette Association of America, in response to the worldwide need for a more organized and collaborative effort, launched an international TS DBS registry and database. The main goal of the project has been to share data, uncover best practices, improve outcomes, and to provide critical information to regulatory agencies. The international registry and database has improved the communication and collaboration among TS DBS centers worldwide. In this paper we will review some of the key operation details for the international TS DBS database and registry.

Indexed as

databasedeep brain stimulationregistryregulatory agenciesticsTourette syndrome

Identifiers

PMID27199634
PMCPMC4842757
OpenAlexW2343712834

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.