ArticleInternational journal of nanomedicine2016
Manganese dioxide nanosheets-based redox/pH-responsive drug delivery system for cancer theranostic application.
Article in International journal of nanomedicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- ROS-Responsive MnOJournal of nanobiotechnology · 2026Article
- Biodegradation of patulin in apple juice by phosphoribosyl transferase (URA5): implications for food safety.BMC biotechnology · 2025Article
- Embracing cancer immunotherapy with manganese particles.Cellular oncology (Dordrecht, Netherlands) · 2025Review
- Periodic Table of Immunomodulatory Elements and Derived Two-Dimensional Biomaterials.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Manganese Oxide Nanoparticles for MRI-Based Multimodal Imaging and Theranostics.Molecules (Basel, Switzerland) · 2024Review
- Recent Advances on Pt-Based Compounds for Theranostic Applications.Molecules (Basel, Switzerland) · 2024Review
- Redox double-switch cancer theranostics through Pt(IV) functionalised manganese dioxide nanostructures.Nanoscale · 2023Article
- Recent development of pH-responsive theranostic nanoplatforms for magnetic resonance imaging-guided cancer therapy.Exploration (Beijing, China) · 2023Review
- Redox/pH-responsive hollow manganese dioxide nanoparticles for thyroid cancer treatment.Frontiers in chemistry · 2023Article
- 2D layered nanomaterials for therapeutics delivery.Current opinion in biomedical engineering · 2021Article
- Emerging 2D Nanomaterials for Biomedical Applications.Materials today (Kidlington, England) · 2021Article
- Recent Advances of Manganese-Based Hybrid Nanomaterials for Cancer Precision Medicine.Frontiers in oncology · 2021Review
- Smart magnetic resonance imaging-based theranostics for cancer.Theranostics · 2021Review
- A nano-integrated diagnostic and therapeutic platform with oxidation-reduction reactions in tumor microenvironments.Nanoscale advances · 2020Article
- Manganese Oxide Nanoparticles As MRI Contrast Agents In Tumor Multimodal Imaging And Therapy.International journal of nanomedicine · 2019Review
- Applications of Nanosheets in Frontier Cellular Research.Nanomaterials (Basel, Switzerland) · 2018Review
- Hypoxia-activated prodrugs and redox-responsive nanocarriers.International journal of nanomedicine · 2018Review
- Theranostic Probes for Targeting Tumor Microenvironment: An Overview.International journal of molecular sciences · 2017Review
- Redox-Responsive Manganese Dioxide Nanoparticles for Enhanced MR Imaging and Radiotherapy of Lung Cancer.Frontiers in chemistry · 2017Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to construct redox- and pH-responsive degradable manganese dioxide (MnO2) nanosheets for cancer theranostic application. The small MnO2 nanosheets were synthesized, and then functionalized by hyaluronic acid (HA), demonstrating excellent stability and tumor-targeting ability. Cisplatin (cis-diamminedichloroplatinum [CDDP]) was absorbed by the nanosheets through a physical action, which was designed as MnO2/HA/CDDP. The prepared MnO2/HA/CDDP formulation was able to efficiently deliver CDDP to tumor cells in vitro and in vivo, resulting in improved therapeutic efficiency. Subsequently, they were triggered by lower pH and higher level of reduced glutathione to generate Mn(2+), enabling magnetic resonance imaging. The smart multifunctional system combining efficient magnetic resonance imaging and chemotherapy has the potential to be used as a tumor-targeting theranostic nanomedicine.
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Registered trials
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