ArticleMediators of inflammation2016
Correlation between Serum Osteopontin and miR-181a Levels in Allergic Rhinitis Children.
Article in Mediators of inflammation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 21 citations in OpenAlex.
- MicroRNAs-Are They Possible Markers of Allergic Diseases and Efficient Immunotherapy?International journal of molecular sciences · 2026Review
- The immune duality of osteopontin and its therapeutic implications for kidney transplantation.Frontiers in immunology · 2025Review
- Osteopontin mediated eosinophils activation by group II innate lymphoid cells.The World Allergy Organization journal · 2022Article
- Genetics and Epigenetics in Allergic Rhinitis.Genes · 2021Review
- MicroRNAs: Potential Biomarkers and Targets of Therapy in Allergic Diseases?Archivum immunologiae et therapiae experimentalis · 2019Review
- Correlation of microRNA profiles with disease risk and severity of allergic rhinitis.International journal of clinical and experimental pathology · 2018Article
- Osteopontin plays a pivotal role in increasing severity of respiratory syncytial virus infection.PloS one · 2018Article
- Effects of anticholinergic agent on miRNA profiles and transcriptomes in a murine model of allergic rhinitis.Molecular medicine reports · 2017Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOsteopontin (OPN) has been proved to be associated with allergic airway inflammation. However, the roles of OPN and its regulation in childhood allergic rhinitis (AR) are poorly understood.
objectiveThis study aims to evaluate the expression of OPN and miR-181a in children with AR and their association with Th1/Th2 immune response.
methodsChildren who suffered from AR were included along with control subjects. Serum was collected to examine the level of OPN and Th1/Th2 cytokines by enzyme-linked immunosorbent assay (ELISA) and the level of miR-181a by quantitative polymerase chain reaction (qPCR).
resultsChildren with AR had significantly higher serum levels of OPN and lower serum levels of miR-181a than healthy controls. Furthermore, serum levels of OPN were positively correlated with Th2 cytokine and negatively correlated with Th1 cytokine. On the contrary, miR-181a level had a negative correlation with IL-4/IL-5 and positive correlation with IFN-γ/IL-12. More importantly, there was also significant negative correlation between OPN and miR-181a.
conclusionThe OPN protein and miR-181a levels may serve as predictors of disease severity in childhood AR and appear to be promising targets for modulating AR.
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Registered trials
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