ArticleThe Journal of comparative neurology2017
Patterns of cell death in the perinatal mouse forebrain.
Article in The Journal of comparative neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 44 citations in OpenAlex.
- The microbiota shapes the development of the mouse hypothalamic paraventricular nucleus.Hormones and behavior · 2025Article
- The inflammatory response to birth requires MyD88 and is driven by both mother and offspring.Brain, behavior, and immunity · 2024Article
- Lasting impact of postnatal maternal separation on the developing BNST: Lifelong socioemotional consequences.Neuropharmacology · 2023Review
- Developmental patterning of peptide transcription in the central circadian clock in both sexes.Frontiers in neuroscience · 2023Article
- Brain effects of gestating germ-free persist in mouse neonates despite acquisition of a microbiota at birth.Frontiers in neuroscience · 2023Article
- Estimates of total neuron number show that neonatal ethanol causes immediate and lasting neuron loss in cortical and subcortical areas.Frontiers in neuroscience · 2023Article
- Differential effects of early or late exposure to prenatal maternal immune activation on mouse embryonic neurodevelopment.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Perinatal phthalate exposure increases developmental apoptosis in the rat medial prefrontal cortex.Neurotoxicology · 2021Article
- Cell death in the male and female rat medial prefrontal cortex during early postnatal development.IBRO neuroscience reports · 2021Article
- Birth elicits a conserved neuroendocrine response with implications for perinatal osmoregulation and neuronal cell death.Scientific reports · 2021Article
- First Encounters: Effects of the Microbiota on Neonatal Brain Development.Frontiers in cellular neuroscience · 2021Review
- Genesis of the Master Circadian Pacemaker in Mice.Frontiers in neuroscience · 2021Review
- Interaction of Tau, IL-6 and mitochondria on synapse and cognition following sevoflurane anesthesia in young mice.Brain, behavior, & immunity - health · 2020Article
- Exposure to prenatal PCBs shifts the timing of neurogenesis in the hypothalamus of developing rats.Journal of experimental zoology. Part A, Ecological and integrative physiology · 2020Article
- Disruption of Transient SERT Expression in Thalamic Glutamatergic Neurons Alters Trajectory of Postnatal Interneuron Development in the Mouse Cortex.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Effects of neonatal ethanol on cerebral cortex development through adolescence.Brain structure & function · 2019Article
- Birth delivery mode alters perinatal cell death in the mouse brain.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- The microbiota influences cell death and microglial colonization in the perinatal mouse brain.Brain, behavior, and immunity · 2018Article
- Article
- Sex differences in microglial phagocytosis in the neonatal hippocampus.Brain, behavior, and immunity · 2017Article
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
The importance of cell death in brain development has long been appreciated, but many basic questions remain, such as what initiates or terminates the cell death period. One obstacle has been the lack of quantitative data defining exactly when cell death occurs. We recently created a "cell death atlas," using the detection of activated caspase-3 (AC3) to quantify apoptosis in the postnatal mouse ventral forebrain and hypothalamus, and found that the highest rates of cell death were seen at the earliest postnatal ages in most regions. Here we have extended these analyses to prenatal ages and additional brain regions. We quantified cell death in 16 forebrain regions across nine perinatal ages from embryonic day (E) 17 to postnatal day (P) 11 and found that cell death peaks just after birth in most regions. We found greater cell death in several regions in offspring delivered vaginally on the day of parturition compared with those of the same postconception age but still in utero at the time of collection. We also found massive cell death in the oriens layer of the hippocampus on P1 and in regions surrounding the anterior crossing of the corpus callosum on E18 as well as the persistence of large numbers of cells in those regions in adult mice lacking the pro-death Bax gene. Together these findings suggest that birth may be an important trigger of neuronal cell death and identify transient cell groups that may undergo wholesale elimination perinatally. J. Comp. Neurol. 525:47-64, 2017. © 2016 Wiley Periodicals, Inc.
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