Evidence map›Paper›PMID 27199164›Full record

ArticleScientific reports2016

The Effects of Tumstatin on Vascularity, Airway Inflammation and Lung Function in an Experimental Sheep Model of Chronic Asthma.

Joanne Van der Velden, Louise M Harkness, Donna M Barker, Garry J Barcham, Cathryn L Ugalde, Emmanuel Koumoundouros, Heidi Bao, Louise A Organ, Ana Tokanovic, Janette K Burgess and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Basement membranes in lung development, disease, and repair.Matrix biology : journal of the International Society for Matrix Biology · 2025
    Review
  2. Article
  3. Beyond classical collagen: basement membrane collagen IV in age-associated lung diseases.European respiratory review : an official journal of the European Respiratory Society · 2025
    Review
  4. Review
  5. Review
  6. Review
  7. Review
  8. ERJ open research · 2021
    Article
  9. Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Joanne Van der VeldenFaculty of Veterinary and Agricultural Science, University of Melbourne, Parkville, Australia.
Louise M HarknessWoolcock Institute of Medical Research, University of Sydney, NSW, Australia.
Donna M BarkerFaculty of Veterinary and Agricultural Science, University of Melbourne, Parkville, Australia.
Garry J BarchamFaculty of Veterinary and Agricultural Science, University of Melbourne, Parkville, Australia.
Cathryn L UgaldeFaculty of Veterinary and Agricultural Science, University of Melbourne, Parkville, Australia.
Emmanuel KoumoundourosDepartment of Electrical and Electronic Engineering, University of Melbourne, Parkville, Australia.
Heidi BaoFaculty of Veterinary and Agricultural Science, University of Melbourne, Parkville, Australia.
Louise A OrganFaculty of Veterinary and Agricultural Science, University of Melbourne, Parkville, Australia.
Ana TokanovicFaculty of Veterinary and Agricultural Science, University of Melbourne, Parkville, Australia.
Janette K BurgessWoolcock Institute of Medical Research, University of Sydney, NSW, Australia.
Kenneth J SnibsonFaculty of Veterinary and Agricultural Science, University of Melbourne, Parkville, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tumstatin, a protein fragment of the alpha-3 chain of Collagen IV, is known to be significantly reduced in the airways of asthmatics. Further, there is evidence that suggests a link between the relatively low level of tumstatin and the induction of angiogenesis and inflammation in allergic airway disease. Here, we show that the intra-segmental administration of tumstatin can impede the development of vascular remodelling and allergic inflammatory responses that are induced in a segmental challenge model of experimental asthma in sheep. In particular, the administration of tumstatin to lung segments chronically exposed to house dust mite (HDM) resulted in a significant reduction of airway small blood vessels in the diameter range 10(+)-20 μm compared to controls. In tumstatin treated lung segments after HDM challenge, the number of eosinophils was significantly reduced in parenchymal and airway wall tissues, as well as in the bronchoalveolar lavage fluid. The expression of VEGF in airway smooth muscle was also significantly reduced in tumstatin-treated segments compared to control saline-treated segments. Allergic lung function responses were not attenuated by tumstatin administration in this model. The data are consistent with the concept that tumstatin can act to suppress vascular remodelling and inflammation in allergic airway disease.

Indexed as

Airway ResistanceAllergensAnimalsAsthmaAutoantigensBronchoalveolar Lavage FluidChronic DiseaseCollagen Type IVDermatophagoides pteronyssinusFemaleInflammationLungMuscle, SmoothSheep, DomesticVascular Endothelial Growth Factor AVascular RemodelingAllergensAutoantigensCollagen Type IVtype IV collagen alpha3 chainVascular Endothelial Growth Factor A

Identifiers

PMID27199164
PMCPMC4873797

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.