ArticleChemistry (Weinheim an der Bergstrasse, Germany)2016
Harnessing Thin-Film Continuous-Flow Assembly Lines.
Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Developing Novel Fabrication and Optimisation Strategies on Aggregation-Induced Emission Nanoprobe/Polyvinyl Alcohol Hydrogels for Bio-Applications.Molecules (Basel, Switzerland) · 2022Article
- Neutron imaging and modelling inclined vortex driven thin films.Scientific reports · 2019Article
- 3D Printing Bioactive PLGA Scaffolds Using DMSO as a Removable Solvent.Bioprinting (Amsterdam, Netherlands) · 2018Article
- Vortex Fluidic Chemical Transformations.Chemistry (Weinheim an der Bergstrasse, Germany) · 2017Review
- A Unified Continuous Flow Assembly-Line Synthesis of Highly Substituted Pyrazoles and Pyrazolines.Angewandte Chemie (International ed. in English) · 2017Article
- Ten-Minute Protein Purification and Surface Tethering for Continuous-Flow Biocatalysis.Angewandte Chemie (International ed. in English) · 2017Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Inspired by nature's ability to construct complex molecules through sequential synthetic transformations, an assembly line synthesis of α-aminophosphonates has been developed. In this approach, simple starting materials are continuously fed through a thin-film reactor where the intermediates accrue molecular complexity as they progress through the flow system. Flow chemistry allows rapid multistep transformations to occur via reaction compartmentalization, an approach not amenable to using conventional flasks. Thin film processing can also access facile in situ solvent exchange to drive reaction efficiency, and through this method, α-aminophosphonate synthesis requires only 443 s residence time to produce 3.22 g h(-1) . Assembly-line synthesis allows unprecedented reaction flexibility and processing efficiency.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.