ArticleHuman brain mapping2016
A comprehensive tractography study of patients with bipolar disorder and their unaffected siblings.
Article in Human brain mapping, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- White Matter Tract Alterations in Bipolar Disorder: A Systematic Review and Meta-Analysis of Diffusion Tensor Imaging Studies.Brain and behavior · 2026Pooled it
- Common and unique white matter fractional anisotropy patterns in patients with schizophrenia with medication-resistant auditory verbal hallucinations: a retrospective tract-based spatial statistics study.Schizophrenia (Heidelberg, Germany) · 2025Article
- Association Between White Matter Tract Integrity and Frontal-Executive Function in Non-Geriatric Adult Patients With Major Depressive Disorder.Psychiatry investigation · 2024Article
- Tract-based analyses of white matter in schizophrenia, bipolar disorder, aging, and dementia using high spatial and directional resolution diffusion imaging: a pilot study.Frontiers in psychiatry · 2024Article
- Single episode brief psychotic disorder versus bipolar disorder: A diffusion tensor imaging and executive functions study.Schizophrenia research. Cognition · 2022Review
- Evaluating endophenotypes for bipolar disorder.International journal of bipolar disorders · 2021Review
- A quality control pipeline for probabilistic reconstruction of white-matter pathways.Journal of neuroscience methods · 2021Article
- Integrity of the uncinate fasciculus is associated with the onset of bipolar disorder: a 6-year followed-up study.Translational psychiatry · 2021Article
- Making Sense of Connectivity.The international journal of neuropsychopharmacology · 2019Review
- Diffusion imaging markers of bipolar versus general psychopathology risk in youth at-risk.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- White matter aberrations and age-related trajectories in patients with schizophrenia and bipolar disorder revealed by diffusion tensor imaging.Scientific reports · 2018Article
- Neuron-glia Interaction as a Possible Pathophysiological Mechanism of Bipolar Disorder.Current neuropharmacology · 2018Review
- Clinical Findings Documenting Cellular and Molecular Abnormalities of Glia in Depressive Disorders.Frontiers in molecular neuroscience · 2018Review
- Automated tractography in patients with temporal lobe epilepsy using TRActs Constrained by UnderLying Anatomy (TRACULA).NeuroImage. Clinical · 2017Article
- Twin studies for the investigation of the relationships between genetic factors and brain abnormalities in bipolar disorder.Epidemiology and psychiatric sciences · 2016Article
- Preliminary Study of White Matter Abnormalities and Associations With the Metabotropic Glutamate Receptor 5 to Distinguish Bipolar and Major Depressive Disorders.Chronic stress (Thousand Oaks, Calif.)Article
- Quantitative magnetic resonance imaging traits as endophenotypes for genetic mapping in epilepsy.NeuroImage. ClinicalReview
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Authors and funding
11 authors.
Funding
Abstract
backgroundDiffusion tensor imaging studies show reductions in fractional anisotropy (FA) in individuals with bipolar disorder and their unaffected siblings. However, the use of various analysis methods is an important source of between-study heterogeneity. Using tract-based spatial statistics, we previously demonstrated widespread FA reductions in patients and unaffected relatives. To better interpret the neuroanatomical pattern of this previous finding and to assess the influence of methodological heterogeneity, we here applied tractography to the same sample.
methodsDiffusion-weighted images were acquired for 96 patients, 69 unaffected siblings and 56 controls. We applied TRACULA, an extension of a global probabilistic tractography algorithm, to automatically segment 18 major fiber tracts. Average FA within each tract and at each cross-section along each tract was compared between groups.
resultsPatients had reduced FA compared to healthy controls and their unaffected siblings in general, and in particular in the parietal part of the superior longitudinal fasciculus. In unaffected siblings, FA was nominally reduced compared to controls in the corpus callosum. Point-wise analyses indicated that similar effects were present along extended sections, but with variable effect sizes. Current symptom severity negatively correlated with FA in several fronto-limbic association tracts.
conclusionsThe differential sensitivity of analysis techniques likely explains between-study heterogeneity in anatomical localization of FA reductions. The present tractography analysis confirms the presence of overall FA reductions in patients with bipolar disorder, which are most pronounced in the superior longitudinal fasciculus. Unaffected siblings may display similar, albeit more subtle and anatomically restricted FA reductions. Hum Brain Mapp 37:3474-3485, 2016. © 2016 Wiley Periodicals, Inc.
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