Evidence map›Paper›PMID 27198742›Full record

ArticleJournal of surgical oncology2016

Assessing the impact of common bile duct resection in the surgical management of gallbladder cancer.

Faiz Gani, Stefan Buettner, Georgios A Margonis, Cecilia G Ethun, George Poultsides, Thuy Tran, Kamran Idrees, Chelsea A Isom, Ryan C Fields, Bradley Krasnick and 12 more

Open access · greenAbstract readComparative Study
In one paragraph

Article in Journal of surgical oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 40 citations in OpenAlex.

  1. Observational
  2. Article
  3. Article
  4. Incidental Gallbladder Cancer: A Comprehensive Review.Journal of gastrointestinal cancer · 2025
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Gallbladder cancer: Historical treatment and new management options.World journal of gastrointestinal oncology · 2021
    Review
  10. Article
  11. The Landmark Series: Gallbladder Cancer.Annals of surgical oncology · 2020
    Review
  12. Article
  13. Article
  14. Updates on Gallbladder Cancer Management.Current oncology reports · 2018
    Review
  15. Surgical Site Infection Is Associated with Tumor Recurrence in Patients with Extrahepatic Biliary Malignancies.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2017
    Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 10 institutions in 1 country.

Faiz GaniDepartment of Surgery, Johns Hopkins Hospital, Baltimore, Maryland.
Stefan BuettnerDepartment of Surgery, Johns Hopkins Hospital, Baltimore, Maryland.
Georgios A MargonisDepartment of Surgery, Johns Hopkins Hospital, Baltimore, Maryland.
Cecilia G EthunDepartment of Surgery, Winship Cancer Institute, Emory University, Atlanta, Georgia.
George PoultsidesDepartment of Surgery, Stanford University Medical Center, Stanford, California.
Thuy TranDepartment of Surgery, Stanford University Medical Center, Stanford, California.
Kamran IdreesDepartment of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee.
Chelsea A IsomDepartment of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee.
Ryan C FieldsDepartment of Surgery, Washington University School of Medicine, St Louis, Missouri.
Bradley KrasnickDepartment of Surgery, Washington University School of Medicine, St Louis, Missouri.
Sharon M WeberDepartment of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
Ahmed SalemDepartment of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
Robert C G MartinDepartment of Surgery, University of Louisville, Louisville, Kentucky.
Charles ScogginsDepartment of Surgery, University of Louisville, Louisville, Kentucky.
Perry ShenDepartment of Surgery, Wake Forest University, Winston-Salem, North Carolina.
Harveshp D MogalDepartment of Surgery, Wake Forest University, Winston-Salem, North Carolina.
Carl SchmidtDepartment of Surgery, Ohio State University Comprehensive Cancer Center, Columbus, Ohio.
Eliza BealDepartment of Surgery, Ohio State University Comprehensive Cancer Center, Columbus, Ohio.
Ioannis HatzarasDepartment of Surgery, New York University, New York, New York.
Rivfka ShenoyDepartment of Surgery, New York University, New York, New York.
Shishir K MaithelDepartment of Surgery, Winship Cancer Institute, Emory University, Atlanta, Georgia.
Timothy M PawlikDepartment of Surgery, Johns Hopkins Hospital, Baltimore, Maryland.
Johns Hopkins Hospital · USEmory University · USNew York University · USStanford University · USThe Ohio State University · USUniversity of Louisville · USUniversity of Wisconsin–Madison · USVanderbilt University Medical Center · USWake Forest University · USWashington University in St. Louis · US

Funding

Vanderbilt Clinical Oncology Research Career Development ProgramK12CA090625 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Debra L. Friedman, Paula Jill Hurley · 2001 to 2026
$16.9M
Advanced Research Training in Immunology for Surgery Trainees (ARTIST)T32AI106704 · NIAID · OHIO STATE UNIVERSITY · PI GINNY L BUMGARDNER, Jon R Wisler · 2014 to 2026
$3.5M
NCI NIH HHS K12 CA090625NIAID NIH HHS T32 AI106704
6 · The paper itself

Abstract

backgroundAlthough radical re-resection for gallbladder cancer (GBC) has been advocated, the optimal extent of re-resection remains unknown. The current study aimed to assess the impact of common bile duct (CBD) resection on survival among patients undergoing surgery for GBC.

methodsPatients undergoing curative-intent surgery for GBC were identified using a multi-institutional cohort of patients. Multivariable Cox-proportional hazards regression was performed to identify risk factors for a poor overall survival (OS).

resultsAmong the 449 patients identified, 26.9% underwent a concomitant CBD resection. The median number of lymph nodes harvested did not differ based on CBD resection (CBD, 4 [IQR: 2-9] vs. no CBD, 3 [IQR: 1-7], P = 0.108). While patients who underwent a CBD resection had a worse OS, after adjusting for potential confounders, CBD resection did not impact OS (HR = 1.40, 95%CI 0.87-2.27, P = 0.170). Rather, the presence of advanced disease (T3: HR = 3.11, 95%CI 1.22-7.96, P = 0.018; T4: HR = 7.24, 95%CI 1.70-30.85, P = 0.007) and the presence of disease at the surgical margin (HR = 2.58, 95%CI 1.26-5.31, P = 0.010) were predictive of a worse OS.

conclusionsCBD resection did not yield a higher lymph node count and was not associated with an improved survival. Routine CBD excision in the re-resection of GBC is unwarranted and should only be performed selectively. J. Surg. Oncol. 2016;114:176-180. © 2016 Wiley Periodicals, Inc.

Indexed as

AgedCommon Bile DuctFemaleGallbladder NeoplasmsHumansLymph NodesMaleMiddle AgedMultivariate AnalysisProportional Hazards ModelsRisk Factorscommon bile ductgallbladder cancersurgical resectionsurvival

Identifiers

PMID27198742
PMCPMC5450028
OpenAlexW2407122952

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.