Observational studyBMC infectious diseases2016
Poor tuberculosis treatment outcomes in Southern Mozambique (2011-2012).
Observational study in BMC infectious diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers, 2 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- Tuberculosis Treatment Outcome and Predictors in Africa: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2021Pooled it
- Mortality in children diagnosed with tuberculosis: a systematic review and meta-analysis.The Lancet. Infectious diseases · 2017Pooled it
- Factors associated with unsuccessful tuberculosis treatment outcome in children in four provinces of Mozambique: a retrospective cohort study, 2018-2021.BMC infectious diseases · 2026Article
- Within-host evolution of drug tolerance inJAC-antimicrobial resistance · 2026Article
- A stool based qPCR for the diagnosis of TB in children and people living with HIV in Uganda, Eswatini and Mozambique (Stool4TB): a protocol for a multicenter diagnostic evaluation.BMC infectious diseases · 2024Article
- Determinants of unsuccessful tuberculosis treatment outcome in Southwest Ethiopia regional state public hospitals, 2022: a multi-center case control study.Frontiers in public health · 2024Article
- Indonesian Ulema Council Fatwa on Religious Activities During the COVID-19 Pandemic: An Investigation of Muslim Attitudes and Practices.Journal of religion and health · 2023Article
- Altered Mental Status Among Febrile Hospitalized HIV-Infected Children Aged 0-59 Months in Mozambique.Journal of tropical pediatrics · 2021Observational
- Article
- Mortality and risk of tuberculosis among people living with HIV in whom TB was initially ruled out.Scientific reports · 2020Article
- Treatment success and mortality among adults with tuberculosis in rural eastern Uganda: a retrospective cohort study.BMC public health · 2020Article
- Multiple Concurrent Illnesses Associated with Anemia in HIV-Infected and HIV-Exposed Uninfected Children Aged 6-59 Months, Hospitalized in Mozambique.The American journal of tropical medicine and hygiene · 2020Article
- Article
- Diabetes Mellitus among new tuberculosis patients in Bamako, Mali.Journal of clinical tuberculosis and other mycobacterial diseases · 2019Article
- Tuberculosis Treatment Outcomes Among Children in Rural Southern Mozambique: A 12-year Retrospective Study.The Pediatric infectious disease journal · 2019Article
- BCG vaccination in southern rural Mozambique: an overview of coverage and its determinants based on data from the demographic and health surveillance system in the district of Manhiça.BMC pediatrics · 2018Article
- Predictors of therapy failure in newly diagnosed pulmonary tuberculosis cases in Beira, Mozambique.BMC research notes · 2018Observational
- Impact of alcohol disorder and the use of illicit drugs on tuberculosis treatment outcomes: a retrospective cohort study.Archives of public health = Archives belges de sante publique · 2018Article
- IP-10 Kinetics in the First Week of Therapy are Strongly Associated with Bacteriological Confirmation of Tuberculosis Diagnosis in HIV-Infected Patients.Scientific reports · 2017Article
- Knowledge, attitudes and practices regarding tuberculosis care among health workers in Southern Mozambique.BMC pulmonary medicine · 2017Article
Corrections and comments
- Erratum issued
Authors and funding
12 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn Mozambique, there is limited data regarding the monitoring of Tuberculosis (TB) treatment results and determinants of adverse outcomes under routine surveillance conditions. The objectives of this study were to evaluate treatment outcomes among TB patients, analyze factors associated with a fatal outcome and determine the proportion of deaths attributable to TB in the district of Manhiça, Southern Mozambique.
methodsThis is a retrospective observational study based on TB patients diagnosed in the period 2011-2012. We used three different data sources: a) TB related variables collected by the National TB Control Program in the district of Manhiça for all TB cases starting treatment in the period 2011-2012. b) Population estimates for the district were obtained through the Mozambican National Statistics Institute. c) Deaths and other relevant demographic variables were collected from the Health and Demographic Surveillance System at Manhiça Health Research Center. WHO guidelines were used to define TB cases and treatment outcomes.
resultsOf the 1957 cases starting TB treatment in the period 2011-2012, 294 patients (15.1 %) died during anti-tuberculous treatment. Ten per cent of patients defaulted treatment. The proportion of patients considered to have treatment failure was 1.1 %. HIV infection (OR 2.73; 95 % CI: 1.70-4.38), being male (OR: 1.39; 95 % CI 1.01-1.91) and lack of laboratory confirmation (OR: 1.54; 95 % CI 1.12-2.13) were associated with dying during the course of TB treatment (p value <0.05). The contribution of TB to the overall death burden of the district for natural reasons was 6.5 % (95 % CI: 5.5-7.6), higher for males than for females (7.8 %; 95 % CI: 6.1-9.5 versus 5.4 %; 95 % CI: 4.1-6.8 respectively). The age group within which TB was responsible for the highest proportion of deaths was 30-34 among males and 20-24 among females (20 % of all deaths in both cases).
conclusionThis study shows a very high proportion of fatal outcomes among TB cases starting treatment. There is a high contribution of TB to the overall causes of mortality. These results call for action in order to improve TB (and TB/HIV) management and thus treatment outcomes of TB patients.
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