Evidence map›Paper›PMID 27198233›Full record

ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2016

Effect of concomitant vitamin D deficiency or insufficiency on lumbar spine volumetric bone mineral density and trabecular bone score in primary hyperparathyroidism.

M D Walker, I Saeed, J A Lee, C Zhang, D Hans, T Lang, S J Silverberg

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Primary Hyperparathyroidism.The Journal of clinical endocrinology and metabolism · 2018
    Review
  8. Characteristics, management, and outcome of primary hyperparathyroidism at a single clinical center from 2005 to 2016.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2018
    Article
  9. Primary hyperparathyroidism.Nature reviews. Endocrinology · 2018
    Review
  10. Maternal vitamin D and offspring trabecular bone score.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

M D WalkerDepartment of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA. mad2037@columbia.edu.
I SaeedDepartment of Radiology and Biomedical Imaging, University of California at San Francisco, San Francisco, CA, USA.
J A LeeDepartment of Surgery, Columbia University College of Physicians and Surgeons, New York, NY, USA.
C ZhangDepartment of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA.
D HansCenter of Bone Diseases, Bone and Joint Department, Lausanne University Hospital, Lausanne, Switzerland.
T LangDepartment of Radiology and Biomedical Imaging, University of California at San Francisco, San Francisco, CA, USA.
S J SilverbergDepartment of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA.
Columbia University · USUniversity of Lausanne · CH

Funding

Vitamin D Deficiency in Primary HyperparathyroidismR01DK084986 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SILVERBERG, SHONNI J · 2010 to 2014
$3.0M
Non-Classical Manifestations of Primary HyperparathyroidismK24DK074457 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SILVERBERG, SHONNI J · 2006 to 2016
$1.7M
NIDDK NIH HHS K24 DK074457NIDDK NIH HHS R01 DK084986
6 · The paper itself

Abstract

unlabelledLower vitamin D and higher parathyroid hormone (PTH) levels are associated with higher volumetric BMD and bone strength at the lumbar spine as measured by central quantitative computed tomography in primary hyperparathyroidism (PHPT), but there are no differences in bone microarchitecture as measured by trabecular bone score (TBS).

introductionThe purpose of this study was to evaluate the association between 25-hydroxyvitamin D (25OHD) and volumetric bone mineral density (vBMD) and the TBS at the lumbar spine (LS) in PHPT.

methodsThis is a cross-sectional analysis of PHPT patients with and without low 25OHD. We measured vBMD with quantitative computed tomography (cQCT) and TBS by dual-energy X-ray absorptiometry (DXA) at the LS in 52 and 88 participants, respectively.

resultsIn the cQCT cohort, those with lower vitamin D (<20 vs. 20-29 vs. ≥30 ng/ml) tended to be younger (p = 0.05), were less likely to use vitamin D supplementation (p < 0.01), and had better renal function (p = 0.03). Those with 25OHD <20 ng/ml had 80 and 126 % higher serum PTH levels respectively vs. those with 25OHD 20-29 ng/ml (p = 0.002) and 25OHD ≥30 ng/ml (p < 0.0001). Covariate-adjusted integral and trabecular vBMD were higher in those with 25OHD 20-29 vs. those with 25OHD ≥30 ng/ml, but those with 25OHD <20 did not differ. Because there were few participants with 25OHD deficiency, we also compared those with vitamin D <30 vs. ≥30 ng/ml. Covariate-adjusted integral and trabecular vBMD were 23 and 30 % higher respectively (both p < 0.05) in those with vitamin D <30 vs. ≥30 ng/ml. TBS was in the partially degraded range but did not differ by vitamin D status.

conclusionIn mild PHPT, lower 25OHD is associated with higher PTH, but vitamin D deficiency and insufficiency using current clinical thresholds did not adversely affect lumbar spine skeletal health in PHPT. Further work is needed to determine if higher vBMD in those with lower vitamin D is due to an anabolic effect of PTH.

Indexed as

Bone DensityAgedCancellous BoneCross-Sectional StudiesFemaleHumansHyperparathyroidism, PrimaryMaleMiddle AgedParathyroid HormoneVitamin DVitamin D Deficiency25-hydroxyvitamin DParathyroid HormoneVitamin DCentral quantitative computed tomographyPrimary hyperparathyroidismTrabecular bone scoreVitamin D deficiencyVolumetric bone density

Identifiers

PMID27198233
PMCPMC5555733
OpenAlexW2399894379

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.