Evidence map›Paper›PMID 27198187›Full record

Trial reportThe British journal of nutrition2016

Mycoprotein reduces energy intake and postprandial insulin release without altering glucagon-like peptide-1 and peptide tyrosine-tyrosine concentrations in healthy overweight and obese adults: a randomised-controlled trial.

Jeanne H Bottin, Jonathan R Swann, Eleanor Cropp, Edward S Chambers, Heather E Ford, Mohammed A Ghatei, Gary S Frost

Registry-linked trialOpen access · hybridAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The British journal of nutrition, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02053025 (Appetite Regulation and Mycoprotein), which is not on this map. Cited by 30 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 3 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02053025 nacompletednot on this map

Appetite Regulation and Mycoprotein

TypeinterventionalSponsorImperial College LondonRan2010 to 2012Enrolled52ConditionsAppetite, Energy IntakeArmsmycoprotein, control protein
3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 3 syntheses or guidelines pooled it, 99 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Trial
  6. Trial
  7. Trial
  8. Article
  9. Article
  10. Article
  11. Fungi as Food.Current topics in microbiology and immunology · 2025
    Review
  12. Review
  13. Review
  14. Article
  15. Review
  16. Review
  17. Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Jeanne H Bottin1Nutrition and Dietetics Research Group,Department of Medicine,Division of Diabetes, Endocrinology and Metabolism,Imperial College London,Hammersmith Campus,London W12 0NN,UK.
Jonathan R Swann2Division of Computational and Systems Medicine,Department of Surgery and Cancer,Imperial College London, South Kensington Campus,London SW7 2AZ,UK.
Eleanor Cropp1Nutrition and Dietetics Research Group,Department of Medicine,Division of Diabetes, Endocrinology and Metabolism,Imperial College London,Hammersmith Campus,London W12 0NN,UK.
Edward S Chambers1Nutrition and Dietetics Research Group,Department of Medicine,Division of Diabetes, Endocrinology and Metabolism,Imperial College London,Hammersmith Campus,London W12 0NN,UK.
Heather E Ford1Nutrition and Dietetics Research Group,Department of Medicine,Division of Diabetes, Endocrinology and Metabolism,Imperial College London,Hammersmith Campus,London W12 0NN,UK.
Mohammed A Ghatei3Division of Diabetes, Endocrinology and Metabolism,Department of Medicine,Imperial College London,Hammersmith Campus,London W12 0NN,UK.
Gary S Frost1Nutrition and Dietetics Research Group,Department of Medicine,Division of Diabetes, Endocrinology and Metabolism,Imperial College London,Hammersmith Campus,London W12 0NN,UK.ORCID 0000-0003-0529-6325
Hammersmith Hospital · GBImperial College London · GB

Funding

Biotechnology and Biological Sciences Research CouncilMedical Research CouncilWellcome Trust
6 · The paper itself

Abstract

Dietary mycoprotein decreases energy intake in lean individuals. The effects in overweight individuals are unclear, and the mechanisms remain to be elucidated. This study aimed to investigate the effect of mycoprotein on energy intake, appetite regulation, and the metabolic phenotype in overweight and obese volunteers. In two randomised-controlled trials, fifty-five volunteers (age: 31 (95 % CI 27, 35) years), BMI: 28·0 (95 % CI 27·3, 28·7) kg/m2) consumed a test meal containing low (44 g), medium (88 g) or high (132 g) mycoprotein or isoenergetic chicken meals. Visual analogue scales and blood samples were collected to measure appetite, glucose, insulin, peptide tyrosine-tyrosine (PYY) and glucagon-like peptide-1 (GLP-1). Ad libitum energy intake was assessed after 3 h in part A (n 36). Gastric emptying by the paracetamol method, resting energy expenditure and substrate oxidation were recorded in part B (n 14). Metabonomics was used to compare plasma and urine samples in response to the test meals. Mycoprotein reduced energy intake by 10 % (280 kJ (67 kcal)) compared with chicken at the high content (P=0·009). All mycoprotein meals reduced insulin concentrations compared with chicken (incremental AUClow (IAUClow): -8 %, IAUCmedium: -12 %, IAUChigh: -21 %, P=0·004). There was no significant difference in glucose, PYY, GLP-1, gastric emptying rate and energy expenditure. Following chicken intake, paracetamol-glucuronide was positively associated with fullness. After mycoprotein, creatinine and the deamination product of isoleucine, α-keto-β-methyl-N-valerate, were inversely related to fullness, whereas the ketone body, β-hydroxybutyrate, was positively associated. In conclusion, mycoprotein reduces energy intake and insulin release in overweight volunteers. The mechanism does not involve changes in PYY and GLP-1. The metabonomics analysis may bring new understanding to the appetite regulatory properties of food.

Indexed as

ObesityAdultAnimalsAppetiteAppetite RegulationDietary ProteinsDipeptidesEatingEnergy IntakeFemaleFungal ProteinsFusariumGastric EmptyingGastrointestinal HormonesGlucagon-Like Peptide 1HumansDietary ProteinsDipeptidesFungal ProteinsGastrointestinal HormonesGlucagon-Like Peptide 1InsulinPeptide YYtyrosyltyrosineAppetite hormonesEnergy intakeGAA guanidinoacetic acidGastric emptyingGI gastrointestinalGLP-1 glucagon-like peptide-1IAUC incremental AUCMetabonomicsMycoproteinObesityOverweightPYY peptide tyrosine-tyrosineREE resting energy expenditureT2DM type 2 diabetes mellitus

Identifiers

PMID27198187
PMCPMC4910676
OpenAlexW2403764147

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.