ArticleScientific reports2016
Diverse Genetic Background of Multidrug-Resistant Pseudomonas aeruginosa from Mainland China, and Emergence of an Extensively Drug-Resistant ST292 Clone in Kunming.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed.
- Emergence of outbreak-driving high-riskMicrobial genomics · 2026Article
- Epidemiological and molecular characterisation of carbapenemase-producing Pseudomonas aeruginosa from a tertiary care hospital, India.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Molecular Epidemiology ofAntibiotics (Basel, Switzerland) · 2024Review
- Molecular epidemiology and carbapenem resistance mechanisms ofFrontiers in microbiology · 2024Article
- Whole-genome sequencing reveals high-risk clones ofFrontiers in microbiology · 2023Article
- Resistance genomics and molecular epidemiology of high-risk clones of ESBL-producingFrontiers in cellular and infection microbiology · 2023Article
- Molecular characterization and antibiogram of the carbapenemase gene variants in clinical strains of Pseudomonas aeruginosa.Molecular biology reports · 2022Article
- Decoding Genetic Features and Antimicrobial Susceptibility ofInternational journal of molecular sciences · 2022Article
- Inherent and Composite Hydrogels as Promising Materials to Limit Antimicrobial Resistance.Gels (Basel, Switzerland) · 2022Review
- Emergence of Carbapenem-Resistant ST244, ST292, and ST2446Infection and drug resistance · 2022Article
- Prevalence of the Genes Associated with Biofilm and Toxins Synthesis amongst theAntibiotics (Basel, Switzerland) · 2021Article
- Mobile Carbapenemase Genes inFrontiers in microbiology · 2021Review
- Susceptibility to Imipenem/Relebactam ofInfection and drug resistance · 2021Article
- Novel Chromosome-Borne Accessory Genetic Elements Carrying Multiple Antibiotic Resistance Genes inFrontiers in cellular and infection microbiology · 2021Article
- Analysis of Metallo-β-lactamases, oprD Mutation, and Multidrug Resistance of β-lactam Antibiotic-Resistant Strains of Pseudomonas aeruginosa Isolated from Southern China.Current microbiology · 2020Article
- Genotypic characterisation and antimicrobial resistance of Pseudomonas aeruginosa strains isolated from patients of different hospitals and medical centres in Poland.BMC infectious diseases · 2020Article
- Antimicrobial Resistance in ESKAPE Pathogens.Clinical microbiology reviews · 2020Review
- First Italian outbreak of VIM-producingWorld journal of clinical cases · 2019Article
- Dissemination of Carbapenem-Resistance among Multidrug ResistantInfection & chemotherapy · 2019Article
- Molecular epidemiology of Pseudomonas aeruginosa isolated from infected ICU patients: a French multicenter 2012-2013 study.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2019Article
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8 authors.
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Abstract
For a better understanding of the multidrug resistant Pseudomonas aeruginosa (MDR-PA) epidemiology in mainland China, a nationwide surveillance network of 27 tertiary hospitals was established. Non-duplicate MDR-PA isolates from 254 cases of nosocomial infections, were collected during the period August 2011 to July 2012. Minimum inhibitory concentrations (MICs) of nine antimicrobial agents were determined by broth micro-dilution method according to the CLSI guidelines [M7-A10]. Genotyping analysis was performed by multilocus sequence typing (MLST) and pulsed-field gel electrophoresis (PFGE). The presence of acquired carbapenemases was also determined by molecular approaches for 233 carbapenem-resistant isolates. Carbapenemase genes were detected in 19 (8.2%) isolates, with 13 of these isolates encoding IMP-type enzymes, five with VIM-2, and one with KPC-2. MLST analysis revealed significant genetic diversity among the MDR-PA isolates studied, and 91 STs (including 17 novel STs) were identified. However, a long-term outbreak of an emerging extensively drug-resistant (XDR) ST292/PFGE genotype A clone was detected in a hospital from Southwest China. This study has demonstrated that MDR-PA in mainland China have evolved from diverse genetic backgrounds. Evidence of clonal dissemination of the organism and nosocomial outbreaks in some regions, suggest a need to strengthen existing infection control measures.
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