Evidence map›Paper›PMID 27197987›Full record

ArticleAJNR. American journal of neuroradiology2016

MRI Evaluation of Non-Necrotic T2-Hyperintense Foci in Pediatric Diffuse Intrinsic Pontine Glioma.

O Clerk-Lamalice, W E Reddick, X Li, Y Li, A Edwards, J O Glass, Z Patay

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AJNR. American journal of neuroradiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03620032 (Phase 2 Randomized Study of RT and Reirradiation at Relapse vs Multiple Elective RT Courses With Same Concomitant CT for Newly Diagnosed), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03620032 phase2unknown statusnot on this map

Phase 2 Randomized Study of RT and Reirradiation at Relapse vs Multiple Elective RT Courses With Same Concomitant CT for Newly Diagnosed

TypeinterventionalSponsorFondazione IRCCS Istituto Nazionale dei Tumori, MilanoRan2015 to 2024Enrolled54ConditionsDiffuse Intrinsic Pontine GliomaArmsNimotuzumab, Vinorelbine, Radiotherapy
3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. T2-weighted images are superior to other MR image types for the determination of diffuse intrinsic pontine glioma intratumoral heterogeneity.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

O Clerk-LamaliceFrom the Departments of Diagnostic Imaging (O.C.-L., W.E.R., A.E., J.O.G., Z.P.).ORCID http://orcid.org/0000-0002-1204-2385
W E ReddickFrom the Departments of Diagnostic Imaging (O.C.-L., W.E.R., A.E., J.O.G., Z.P.).ORCID http://orcid.org/0000-0002-1054-1201
X LiBiostatistics (X.L., Y.L.), St. Jude Children's Research Hospital, Memphis, Tennessee.ORCID http://orcid.org/0000-0003-1653-4886
Y LiBiostatistics (X.L., Y.L.), St. Jude Children's Research Hospital, Memphis, Tennessee.ORCID http://orcid.org/0000-0002-7046-4316
A EdwardsFrom the Departments of Diagnostic Imaging (O.C.-L., W.E.R., A.E., J.O.G., Z.P.).ORCID http://orcid.org/0000-0003-2979-5508
J O GlassFrom the Departments of Diagnostic Imaging (O.C.-L., W.E.R., A.E., J.O.G., Z.P.).ORCID http://orcid.org/0000-0001-9679-2054
Z PatayFrom the Departments of Diagnostic Imaging (O.C.-L., W.E.R., A.E., J.O.G., Z.P.) zoltan.patay@stjude.org.ORCID http://orcid.org/0000-0003-1479-9864

Funding

Viral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHARLES ROBERTS · 1985 to 2026
$166.9M
NCI NIH HHS P30 CA021765
6 · The paper itself

Abstract

background and purposeThe conventional MR imaging appearance of diffuse intrinsic pontine glioma suggests intralesional histopathologic heterogeneity, and various distinct lesion components, including T2-hypointense foci, have been described. Here we report the prevalence, conventional MR imaging semiology, and advanced MR imaging features of non-necrotic T2-hyperintense foci in diffuse intrinsic pontine glioma. MATERIALS AND

methodsTwenty-five patients with diffuse intrinsic pontine gliomas were included in this study. MR imaging was performed at 3T by using conventional and advanced MR imaging sequences. Perfusion (CBV), vascular permeability (v

resultsSixteen non-necrotic T2-hyperintense foci were found in 12 tumors. In these foci, ADC values were significantly higher than those in either T2-hypointense foci (

conclusionsNon-necrotic T2-hyperintense foci are common, distinct lesion components within diffuse intrinsic pontine gliomas. Advanced MR imaging data suggest low cellularity and an early stage of angioneogenesis with leaky vessels resulting in expansion of the extracellular space. Because of the lack of biopsy validation, the underlying histoarchitectural and pathophysiologic changes remain unclear; therefore, these foci may correspond to a poorly understood biologic event in tumor evolution.

Identifiers

PMID27197987
PMCPMC5116289

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.