Evidence map›Paper›PMID 27197918›Full record

ReviewJournal of geriatric oncology2016

Chemotherapy-related cognitive impairment in older patients with cancer.

Kah Poh Loh, Michelle C Janelsins, Supriya G Mohile, Holly M Holmes, Tina Hsu, Sharon K Inouye, Meghan S Karuturi, Gretchen G Kimmick, Stuart M Lichtman, Allison Magnuson and 3 more

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of geriatric oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06687291 (Cognitive Impact Associated With Surgery For Gastric Or Esophageal Cancer), which is not on this map. Cited by 67 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06687291 recruitingnot on this mapstarted 2025, after this paper: background citation

Cognitive Impact Associated With Surgery For Gastric Or Esophageal Cancer

Typeobservational_patient_registrySponsorKarolinska InstitutetRan2025 to 2028Enrolled130ConditionsGastroesophageal Cancer (GC), Postoperative Delirium (POD), Quality of Life (QOL), Frailty
3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Risk factors for cancer-related cognitive impairment among individuals with lung cancer: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Trial
  7. Observational
  8. Cancer treatment-related cognitive impairment.Neuro-oncology advances · 2026
    Review
  9. Article
  10. Article
  11. Review
  12. Review
  13. Observational
  14. Article
  15. Review
  16. A nomogram for predicting cancer-related cognitive impairment in lung cancer patients from a nursing science precision health model perspective.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Article
  17. Article
  18. Article
  19. Article
  20. Article

7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Kah Poh LohJames P Wilmot Cancer Institute, University of Rochester, United States. Electronic address: kahpoh_loh@urmc.rochester.edu.
Michelle C JanelsinsJames P Wilmot Cancer Institute, University of Rochester, United States.
Supriya G MohileJames P Wilmot Cancer Institute, University of Rochester, United States.
Holly M HolmesUniversity of Texas Health Science Center at Houston, United States.
Tina HsuThe Ottawa Hospital Cancer Centre, Canada.
Sharon K InouyeHarvard Medical School, Beth Israel Deaconess Medical Center, United States; Hebrew Senior Life, United States.
Meghan S KaruturiUniversity of Texas MD Anderson Cancer Center, United States.
Gretchen G KimmickDuke University Medical Center, United States.
Stuart M LichtmanMemorial Sloan Kettering Cancer Center, United States.
Allison MagnusonJames P Wilmot Cancer Institute, University of Rochester, United States.
Mary I Whitehead
Melisa L WongHelen Diller Family Comprehensive Cancer Center, University of California, San Francisco, United States.
Tim A AhlesMemorial Sloan Kettering Cancer Center, United States.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Collaborations and NCORP Collective ManagementUG1CA189823 · NCI · MAYO CLINIC ROCHESTER · PI Evanthia Galanis, Olwen Hahn · 2014 to 2026
$120.6M
URCC NCORP Research BaseUG1CA189961 · NCI · UNIVERSITY OF ROCHESTER · PI Michelle C Janelsins, KAREN M. MUSTIAN · 2014 to 2026
$67.7M
RESEARCH TRAINING IN GERIATRIC MEDICINET32AG000212 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Alexander Keliimoeanu Smith · 1991 to 2026
$7.7M
Cancer Control Research Training Curriculum (R25T)R25CA102618 · NCI · UNIVERSITY OF ROCHESTER · PI JANELSINS, MICHELLE C, MORROW, GARY R · 2004 to 2018
$6.7M
Clinical and Translational Approaches to Cognitive Impairments in CancerDP2CA195765 · NCI · UNIVERSITY OF ROCHESTER · PI JANELSINS, MICHELLE C · 2014 to 2014
$2.3M
Interventions Targeting Inflammation for Chemotherapy-Related Cognitive ProblemsK07CA168886 · NCI · UNIVERSITY OF ROCHESTER · PI JANELSINS, MICHELLE C · 2013 to 2017
$724k
Geriatric Oncology Research to Improve Clinical CareU13AG038151 · NIA · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI HURRIA, ARTI · 2010 to 2014
$228k
NCI NIH HHS DP2 CA195765NCI NIH HHS K07 CA168886NCI NIH HHS P30 CA008748NCI NIH HHS R25 CA102618NCI NIH HHS UG1 CA189823NCI NIH HHS UG1 CA189961NIA NIH HHS T32 AG000212NIA NIH HHS U13 AG038151
6 · The paper itself

Abstract

Chemotherapy-related cognitive impairment (CRCI) can occur during or after chemotherapy and represents a concern for many patients with cancer. Among older patients with cancer, in whom there is little clinical trial evidence examining side effects like CRCI, many unanswered questions remain regarding risk for and resulting adverse outcomes from CRCI. Given the rising incidence of cancer with age, CRCI is of particular concern for older patients with cancer who receive treatment. Therefore, research related to CRCI in older patients with cancers is a high priority. In this manuscript, we discuss current gaps in research highlighting the lack of clinical studies of CRCI in older adults, the complex mechanisms of CRCI, and the challenges in measuring cognitive impairment in older patients with cancer. Although we focus on CRCI, we also discuss cognitive impairment related to cancer itself and other treatment modalities. We highlight several research priorities to improve the study of CRCI in older patients with cancer.

Indexed as

AgedAge FactorsAntineoplastic AgentsCognitionCognitive DysfunctionHumansMental Status and Dementia TestsNeoplasmsPrevalenceRandomized Controlled Trials as TopicResearchAntineoplastic AgentsCancer treatmentChemotherapyCognitive impairmentOlder patientsResearch gaps

Identifiers

PMID27197918
PMCPMC4969145

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.