Evidence map›Paper›PMID 27197848›Full record

Trial reportStroke2016

Endovascular Hypothermia in Acute Ischemic Stroke: Pilot Study of Selective Intra-Arterial Cold Saline Infusion.

Jian Chen, Liqiang Liu, Hongqi Zhang, Xiaokun Geng, Liqun Jiao, Guilin Li, Jonathan M Coutinho, Yuchuan Ding, David S Liebeskind, Xunming Ji

Registry-linked trialOpen access · bronzeAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Stroke, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03163459 (Short-duration Selective Brain Cooling for Ischemic Stroke Patients Undergoing Mechanical Thrombectomy), which is not on this map. Cited by 65 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed, 3 pooled it
9.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03163459 phase2 / phase3suspendednot on this mapstarted 2018, after this paper: background citation

Short-duration Selective Brain Cooling for Ischemic Stroke Patients Undergoing Mechanical Thrombectomy: a Randomized Controlled Trial

TypeinterventionalSponsorCapital Medical UniversityRan2018 to 2020Enrolled120ConditionsHypothermia, Stroke, AcuteArmsselective brain cooling by cold saline perfusion, mechanical thrombectomy
3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 3 syntheses or guidelines pooled it, 109 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Safety, feasibility, and potential efficacy of intraarterial selective cooling infusion for stroke patients treated with mechanical thrombectomy.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2018
    Trial
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  7. Article
  8. Review
  9. Target temperature management in acute ischemic stroke.Frontiers in molecular biosciences · 2026
    Review
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  11. Review
  12. Review
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  14. Article
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5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Jian ChenFrom the Department of Neurosurgery (J.C., L.L., H.Z., X.G., G.L., X.J.) and Interventional Radiology (L.J.), Xuanwu Hospital, Capital Medical University, Beijing, China; Department of Neurological Surgery, Wayne State University School of Medicine, Detroit, MI (Y.D.); Department of Neurology, David Geffen School of Medicine, University of California Los Angeles Stroke Center (D.S.L.); and Department of Neurology, Academic Medical Center, University of Amsterdam, The Netherlands (J.M.C.).
Liqiang LiuFrom the Department of Neurosurgery (J.C., L.L., H.Z., X.G., G.L., X.J.) and Interventional Radiology (L.J.), Xuanwu Hospital, Capital Medical University, Beijing, China; Department of Neurological Surgery, Wayne State University School of Medicine, Detroit, MI (Y.D.); Department of Neurology, David Geffen School of Medicine, University of California Los Angeles Stroke Center (D.S.L.); and Department of Neurology, Academic Medical Center, University of Amsterdam, The Netherlands (J.M.C.).
Hongqi ZhangFrom the Department of Neurosurgery (J.C., L.L., H.Z., X.G., G.L., X.J.) and Interventional Radiology (L.J.), Xuanwu Hospital, Capital Medical University, Beijing, China; Department of Neurological Surgery, Wayne State University School of Medicine, Detroit, MI (Y.D.); Department of Neurology, David Geffen School of Medicine, University of California Los Angeles Stroke Center (D.S.L.); and Department of Neurology, Academic Medical Center, University of Amsterdam, The Netherlands (J.M.C.).
Xiaokun GengFrom the Department of Neurosurgery (J.C., L.L., H.Z., X.G., G.L., X.J.) and Interventional Radiology (L.J.), Xuanwu Hospital, Capital Medical University, Beijing, China; Department of Neurological Surgery, Wayne State University School of Medicine, Detroit, MI (Y.D.); Department of Neurology, David Geffen School of Medicine, University of California Los Angeles Stroke Center (D.S.L.); and Department of Neurology, Academic Medical Center, University of Amsterdam, The Netherlands (J.M.C.).
Liqun JiaoFrom the Department of Neurosurgery (J.C., L.L., H.Z., X.G., G.L., X.J.) and Interventional Radiology (L.J.), Xuanwu Hospital, Capital Medical University, Beijing, China; Department of Neurological Surgery, Wayne State University School of Medicine, Detroit, MI (Y.D.); Department of Neurology, David Geffen School of Medicine, University of California Los Angeles Stroke Center (D.S.L.); and Department of Neurology, Academic Medical Center, University of Amsterdam, The Netherlands (J.M.C.).
Guilin LiFrom the Department of Neurosurgery (J.C., L.L., H.Z., X.G., G.L., X.J.) and Interventional Radiology (L.J.), Xuanwu Hospital, Capital Medical University, Beijing, China; Department of Neurological Surgery, Wayne State University School of Medicine, Detroit, MI (Y.D.); Department of Neurology, David Geffen School of Medicine, University of California Los Angeles Stroke Center (D.S.L.); and Department of Neurology, Academic Medical Center, University of Amsterdam, The Netherlands (J.M.C.).
Jonathan M CoutinhoFrom the Department of Neurosurgery (J.C., L.L., H.Z., X.G., G.L., X.J.) and Interventional Radiology (L.J.), Xuanwu Hospital, Capital Medical University, Beijing, China; Department of Neurological Surgery, Wayne State University School of Medicine, Detroit, MI (Y.D.); Department of Neurology, David Geffen School of Medicine, University of California Los Angeles Stroke Center (D.S.L.); and Department of Neurology, Academic Medical Center, University of Amsterdam, The Netherlands (J.M.C.).
Yuchuan DingFrom the Department of Neurosurgery (J.C., L.L., H.Z., X.G., G.L., X.J.) and Interventional Radiology (L.J.), Xuanwu Hospital, Capital Medical University, Beijing, China; Department of Neurological Surgery, Wayne State University School of Medicine, Detroit, MI (Y.D.); Department of Neurology, David Geffen School of Medicine, University of California Los Angeles Stroke Center (D.S.L.); and Department of Neurology, Academic Medical Center, University of Amsterdam, The Netherlands (J.M.C.).
David S LiebeskindFrom the Department of Neurosurgery (J.C., L.L., H.Z., X.G., G.L., X.J.) and Interventional Radiology (L.J.), Xuanwu Hospital, Capital Medical University, Beijing, China; Department of Neurological Surgery, Wayne State University School of Medicine, Detroit, MI (Y.D.); Department of Neurology, David Geffen School of Medicine, University of California Los Angeles Stroke Center (D.S.L.); and Department of Neurology, Academic Medical Center, University of Amsterdam, The Netherlands (J.M.C.).
Xunming JiFrom the Department of Neurosurgery (J.C., L.L., H.Z., X.G., G.L., X.J.) and Interventional Radiology (L.J.), Xuanwu Hospital, Capital Medical University, Beijing, China; Department of Neurological Surgery, Wayne State University School of Medicine, Detroit, MI (Y.D.); Department of Neurology, David Geffen School of Medicine, University of California Los Angeles Stroke Center (D.S.L.); and Department of Neurology, Academic Medical Center, University of Amsterdam, The Netherlands (J.M.C.). jixm@ccmu.edu.cn.
University of California, Los Angeles · USNeurological Surgery · USWayne State University · US

Funding

Modeling of Collateral Perfusion in the Ischemic BrainK24NS072272 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LIEBESKIND, DAVID SIGMUND · 2011 to 2015
$939k
NINDS NIH HHS K24 NS072272
6 · The paper itself

Abstract

background and purposeWe conducted a pilot feasibility and safety study of selective brain cooling with intra-arterial infusion of cold saline combined with endovascular reperfusion for acute ischemic stroke.

methodsPatients with large-vessel occlusion within 8 hours after symptom onset were enrolled. All patients received intra-arterial recanalization combined with infusion of cold isotonic saline (4°C) in the ischemic territory through the angiographic catheter.

resultsTwenty-six patients underwent the procedure, which was technically successful in all. The temperature of ischemic cerebral tissue was decreased by at least 2°C during infusion of the cold solution, and systemic temperature was mildly reduced (maximum 0.3°C). No obvious complications related to intra-arterial hypothermia were observed.

conclusionsSelective brain cooling by intra-arterial infusion of cold saline combined with endovascular recanalization therapy in acute ischemic stroke seems feasible and safe.

Indexed as

Endovascular ProceduresAdultAgedBrain IschemiaCold TemperatureCombined Modality TherapyFeasibility StudiesFemaleFibrinolytic AgentsHumansHypothermia, InducedInfusions, Intra-ArterialMaleMiddle AgedPilot ProjectsSodium ChlorideFibrinolytic AgentsSodium Chlorideendovascular procedureshypothermiaintra-arterial infusionsneuroprotectionreperfusion injury

Identifiers

PMID27197848
PMCPMC4927369
OpenAlexW2401831246

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.