ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2017
Lower Pectoralis Muscle Area Is Associated with a Worse Overall Survival in Non-Small Cell Lung Cancer.
Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 83 citations in OpenAlex.
- Body mass index and mortality in lung cancer patients: a systematic review and meta-analysis.European journal of clinical nutrition · 2018Pooled it
- No evidence of pitavastatin effect on muscle area or density among people with HIV.AIDS (London, England) · 2025 · on this mapTrial
- Thoracic Skeletal Muscle Attenuation Predicts Sex-Specific Mortality After Coronary Artery Bypass Grafting-Sex-Specific Insights into Risk Stratification and Frailty Assessment.Medical sciences (Basel, Switzerland) · 2026Article
- Development and validation of a nomogram for predicting pulmonary embolism recurrence using muscle and fat parameters.Scientific reports · 2026Article
- Skeletal muscle loss and associated clinical outcomes in patients with small-cell lung cancer receiving concurrent chemoradiotherapy.BMC cancer · 2025Article
- The cross-sectional area of the pectoralis major muscle and future exacerbations in patients presenting with bronchiectasis exacerbation: a prospective observational study.BMC pulmonary medicine · 2025Observational
- Imaging Cancer-associated Cachexia: Utilizing Clinical Imaging Modalities for Early Diagnosis.Radiology. Imaging cancer · 2025Review
- Sarcopenia Identification Using Alternative Vertebral Landmarks in Individuals with Lung Cancer.Muscles (Basel, Switzerland) · 2024Article
- Pectoral muscle mass is not a robust prognostic factor for survival after left ventricular assist device (LVAD) implantation.Journal of cardiothoracic surgery · 2024Article
- A fully automated pipeline for the extraction of pectoralis muscle area from chest computed tomography scans.ERJ open research · 2024Article
- Skeletal muscle index is associated with long term outcomes after lobectomy for non-small cell lung cancer.BMC cancer · 2023Article
- Pectoralis muscle index might be a factor associated with frailty in older women with breast cancer.Turkish journal of medical sciences · 2023Observational
- Low muscle mass in lung cancer is associated with an inflammatory and immunosuppressive tumor microenvironment.Journal of translational medicine · 2023Article
- Article
- Impact of pectoralis muscle loss on cardiac outcome and survival in Cancer patients who received anthracycline based chemotherapy: retrospective study.BMC cancer · 2022Article
- Reference values of skeletal muscle area for diagnosis of sarcopenia using chest computed tomography in Asian general population.Journal of cachexia, sarcopenia and muscle · 2022Article
- Chest CT-Derived Muscle Analysis in COVID-19 Patients.Tomography (Ann Arbor, Mich.) · 2022Article
- Prevalence of malnutrition in coronavirus disease 19: the NUTRICOV study.The British journal of nutrition · 2021Observational
- Low thoracic muscle mass index on computed tomography predicts adverse outcomes following lobectomy via thoracotomy for lung cancer.Interactive cardiovascular and thoracic surgery · 2021Article
- Unintentional weight loss: what radiologists need to know and what clinicians want to know.Abdominal radiology (New York) · 2021Review
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundMuscle wasting is a component of the diagnosis of cancer cachexia and has been associated with poor prognosis. However, recommended tools to measure sarcopenia are limited by poor sensitivity or the need to perform additional scans. We hypothesized that pectoralis muscle area (PMA) measured objectively on chest CT scan may be associated with overall survival (OS) in non-small cell lung cancer (NSCLC).
methodsWe evaluated 252 cases from a prospectively enrolling lung cancer cohort. Eligible cases had CT scans performed prior to the initiation of surgery, radiation, or chemotherapy. PMA was measured in a semi-automated fashion while blinded to characteristics of the tumor, lung, and patient outcomes.
resultsMen had a significantly greater PMA than women (37.59 vs. 26.19 cm
conclusionsLower PMA measured from chest CT scans obtained at the time of diagnosis of NSCLC is associated with a worse OS. IMPACT: PMA may be a valuable CT biomarker for sarcopenia-associated lung cancer survival. Cancer Epidemiol Biomarkers Prev; 26(1); 38-43. ©2016 AACR SEE ALL THE ARTICLES IN THIS CEBP FOCUS SECTION, "THE OBESITY PARADOX IN CANCER EVIDENCE AND NEW DIRECTIONS".
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