Evidence map›Paper›PMID 27197253›Full record

ArticleCancer research2016

Immunoregulatory Protein B7-H3 Reprograms Glucose Metabolism in Cancer Cells by ROS-Mediated Stabilization of HIF1α.

Sangbin Lim, Hao Liu, Luciana Madeira da Silva, Ritu Arora, Zixing Liu, Joshua B Phillips, David C Schmitt, Tung Vu, Steven McClellan, Yifeng Lin and 4 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 109 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
109citing papers in PubMed, 1 pooled it
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

109 citing papers in PubMed, 1 synthesis or guideline pooled it, 154 citations in OpenAlex.

  1. Pooled it
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  18. Pneumococcal HbioRxiv : the preprint server for biology · 2025
    Article
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49 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 3 countries.

Sangbin LimCenter for Cell Death and Metabolism, Mitchell Cancer Institute, University of South Alabama, Mobile, Alabama.
Hao LiuCenter for Cell Death and Metabolism, Mitchell Cancer Institute, University of South Alabama, Mobile, Alabama. Department of Biochemistry and Molecular Biology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, China. mtan@health.southalabama.edu liuhaoy@hotmail.com Oystein.Fodstad@rr-research.no.
Luciana Madeira da SilvaCenter for Cell Death and Metabolism, Mitchell Cancer Institute, University of South Alabama, Mobile, Alabama.
Ritu AroraCenter for Cell Death and Metabolism, Mitchell Cancer Institute, University of South Alabama, Mobile, Alabama.
Zixing LiuCenter for Cell Death and Metabolism, Mitchell Cancer Institute, University of South Alabama, Mobile, Alabama.
Joshua B PhillipsCenter for Cell Death and Metabolism, Mitchell Cancer Institute, University of South Alabama, Mobile, Alabama.
David C SchmittCenter for Cell Death and Metabolism, Mitchell Cancer Institute, University of South Alabama, Mobile, Alabama.
Tung VuCenter for Cell Death and Metabolism, Mitchell Cancer Institute, University of South Alabama, Mobile, Alabama.
Steven McClellanCenter for Cell Death and Metabolism, Mitchell Cancer Institute, University of South Alabama, Mobile, Alabama.
Yifeng LinDepartment of Neuroscience, University of Minnesota, Minneapolis, Minnesota.
Wensheng LinDepartment of Neuroscience, University of Minnesota, Minneapolis, Minnesota.
Gary A PiazzaCenter for Cell Death and Metabolism, Mitchell Cancer Institute, University of South Alabama, Mobile, Alabama.
Oystein FodstadCenter for Cell Death and Metabolism, Mitchell Cancer Institute, University of South Alabama, Mobile, Alabama. Department of Tumor Biology, Norwegian Radium Hospital, Oslo University Hospital, and Institute for Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway. mtan@health.southalabama.edu liuhaoy@hotmail.com Oystein.Fodstad@rr-research.no.
Ming TanCenter for Cell Death and Metabolism, Mitchell Cancer Institute, University of South Alabama, Mobile, Alabama. Department of Biochemistry and Molecular Biology, University of South Alabama, Mobile, Alabama. mtan@health.southalabama.edu liuhaoy@hotmail.com Oystein.Fodstad@rr-research.no.
USA Mitchell Cancer Institute · USUniversity of Minnesota · USOslo University Hospital · NOSichuan University · CN

Funding

The effects of the unfolded protein response on medulloblastomaR01NS073132 · NINDS · UNIVERSITY OF SOUTH ALABAMA · PI LIN, WENSHENG · 2011 to 2015
$1.6M
Glucose metabolism and ErbB2-mediated cancer progressionR01CA149646 · NCI · UNIVERSITY OF SOUTH ALABAMA · PI TAN, MING · 2011 to 2016
$1.4M
NCI NIH HHS R01 CA149646NINDS NIH HHS R01 NS073132
6 · The paper itself

Abstract

B7-H3 is a member of B7 family of immunoregulatory transmembrane glycoproteins expressed by T cells. While B7-H3 overexpression is associated with poor outcomes in multiple cancers, it also has immune-independent roles outside T cells and its precise mechanistic contributions to cancer are unclear. In this study, we investigated the role of B7-H3 in metabolic reprogramming of cancer cells in vitro and in vivo We found that B7-H3 promoted the Warburg effect, evidenced by increased glucose uptake and lactate production in B7-H3-expressing cells. B7-H3 also increased the protein levels of HIF1α and its downstream targets, LDHA and PDK1, key enzymes in the glycolytic pathway. Furthermore, B7-H3 promoted reactive oxygen species-dependent stabilization of HIF1α by suppressing the activity of the stress-activated transcription factor Nrf2 and its target genes, including the antioxidants SOD1, SOD2, and PRX3. Metabolic imaging of human breast cancer xenografts in mice confirmed that B7-H3 enhanced tumor glucose uptake and tumor growth. Together, our results illuminate the critical immune-independent contributions of B7-H3 to cancer metabolism, presenting a radically new perspective on B7 family immunoregulatory proteins in malignant progression. Cancer Res; 76(8); 2231-42. ©2016 AACR.

Indexed as

AnimalsB7 AntigensBreast NeoplasmsCell Line, TumorCell ProliferationFemaleGlucoseHeterograftsHumansHypoxia-Inducible Factor 1, alpha SubunitMiceMice, NudeReactive Oxygen SpeciesB7 AntigensCD276 protein, humanGlucoseHIF1A protein, humanHypoxia-Inducible Factor 1, alpha SubunitReactive Oxygen Species

Identifiers

PMID27197253
PMCPMC4874665
OpenAlexW2333305684

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.