ArticleCancer research2016
Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations.
Open access · greenAbstract read
In one paragraph
Article in Cancer research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers, 10 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed, 10 pooled it
5.5field-weighted citation impact, top 4% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
78 citing papers in PubMed, 10 syntheses or guidelines pooled it, 118 citations in OpenAlex.
- Multi-ancestry meta-analysis of keloids uncovers novel susceptibility loci in diverse populations.Nature communications · 2025Pooled it
- Pan-cancer and cross-population genome-wide association studies dissect shared genetic backgrounds underlying carcinogenesis.Nature communications · 2023Pooled it
- Cross-cancer pleiotropic analysis identifies three novel genetic risk loci for colorectal cancer.Human molecular genetics · 2023Pooled it
- Pooled it
- Genome-wide association meta-analysis identifies pleiotropic risk loci for aerodigestive squamous cell cancers.PLoS genetics · 2021Pooled it
- Cross-cancer evaluation of polygenic risk scores for 16 cancer types in two large cohorts.Nature communications · 2021Pooled it
- Pooled it
- Neural crest-derived tumor neuroblastoma and melanoma share 1p13.2 as susceptibility locus that shows a long-range interaction with the SLC16A1 gene.Carcinogenesis · 2020Pooled it
- Circadian pathway genetic variation and cancer risk: evidence from genome-wide association studies.BMC medicine · 2018Pooled it
- Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes.Nature genetics · 2017Pooled it
- Large-scale pleiotropic analysis across cancers reveals shared genetic mechanisms and identifies novel functional genes.Briefings in bioinformatics · 2026Article
- Unsupervised characterization of 100,272 EHR patients identifies high-risk groups and comorbidities linked to premature aging.NPJ digital medicine · 2026Article
- Using Importance Sampling to EstimateArXiv · 2026Article
- Haplotype GWAS in Colorectal Cancer Patients with a Family History of Gastric or Prostate Cancer.International journal of molecular sciences · 2026Article
- Integrating genomic structural equation modeling and experimental validation to unravel the genetic basis of male genital lichen sclerosus.Frontiers in immunology · 2026Article
- Loss of ADAM15 prevents necroptosis induction by partial RIPK1 degradation due to enhanced TNF-R1 surface expression and basal caspase-8 activation.Cell communication and signaling : CCS · 2025Article
- Transformer patient embedding using electronic health records enables patient stratification and progression analysis.NPJ digital medicine · 2025Article
- A Haplotype GWAS in Syndromic Familial Colorectal Cancer.International journal of molecular sciences · 2025Article
- Multi-trait GWAS identifies pleiotropic loci associated with colorectal cancer in East Asian populations.Frontiers in genetics · 2025Article
- Language-model-based patient embedding using electronic health records facilitates phenotyping, disease forecasting, and progression analysis.Research square · 2024Article
18 more citing papers are in PubMed but not listed here.
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Authors and funding
137 authors at 8 institutions in 5 countries.
Gordon FehringerLunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada.
Peter KraftHarvard T.H. Chan School of Public Health, Boston, Massachusetts.
Paul D PharoahUniversity of Cambridge, Cambridge, United Kingdom.
Rosalind A EelesInstitute of Cancer Research, London, United Kingdom.
Nilanjan ChatterjeeNational Cancer Instititute, Bethesda, Maryland.
Fredrick R SchumacherUniversity of Southern California, Los Angeles, California.
Joellen M SchildkrautUniversity of Virginia, Charlottesville, Virginia.
Sara LindströmHarvard T.H. Chan School of Public Health, Boston, Massachusetts.
Paul BrennanInternational Agency for Research on Cancer, Lyon, France.
Heike BickeböllerUniversity of Göttingen, Medical School, Göttingen, Germany.
Richard S HoulstonInstitute of Cancer Research, London, United Kingdom.
Maria Teresa LandiNational Cancer Instititute, Bethesda, Maryland.
Neil CaporasoNational Cancer Instititute, Bethesda, Maryland.
Angela RischDivision of Cancer Genetics/Epigenetics, Department of Molecular Biology, University of Salzburg, Salzburg, Austria. Division of Epigenomics and Cancer Risk Factors, DKFZ - German Cancer Research Center, Heidelberg, Germany. Translational Lung Research Center Heidelberg (TLRC-H), German Center for Lung Research (DZL), Heidelberg, Germany.
Ali Amin Al OlamaCambridge University, Cambridge, United Kingdom.
Sonja I BerndtNational Cancer Instititute, Bethesda, Maryland.
Edward L GiovannucciHarvard T.H. Chan School of Public Health, Boston, Massachusetts.
Henrik GrönbergKarolinska Institutet, Stockholm, Sweden.
Zsofia Kote-JaraiInstitute of Cancer Research, London, United Kingdom.
Jing MaHarvard Medical School, Boston Massachusetts. Brigham and Women's Hospital, Boston, Massachusetts.
Kenneth MuirUniversity of Manchester, Manchester, United Kingdom. The University of Warwick, Coventry, United Kingdom.
Meir J StampferHarvard Medical School, Boston Massachusetts.
Victoria L StevensEpidemiology Research Program, American Cancer Society, Atlanta, Georgia.
Fredrik WiklundKarolinska Institutet, Stockholm, Sweden.
Walter C WillettHarvard T.H. Chan School of Public Health, Boston, Massachusetts.
Ellen L GoodeMayo Clinic, Rochester, Minnesota.
Jennifer B PermuthMoffitt Cancer Center, Tampa, Florida.
Harvey A RischYale School of Public Health, New Haven, Connecticut.
Brett M ReidMoffitt Cancer Center, Tampa, Florida.
Stephane BezieauService de Génétique Médicale, Nantes, France.
Hermann BrennerDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany. Division of Preventive Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany. German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Andrew T ChanMassachusetts General Hospital, Boston, Massachusetts.
Jenny Chang-ClaudeNational Center for Tumor Diseases and German Cancer Research Center (DKFZ), Heidelberg, Germany.
Thomas J HudsonOntario Institute for Cancer Research, Toronto, Ontario.
Jonathan K KocarnikFred Hutchinson Cancer Research Center, Seattle, Washington.
Polly A NewcombFred Hutchinson Cancer Research Center, Seattle, Washington.
Robert E SchoenUniversity of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
Martha L SlatteryUniversity of Utah Health Sciences Center, Salt Lake City, Utah.
Emily WhiteFred Hutchinson Cancer Research Center, Seattle, Washington.
Muriel A AdankVU University Medical Center, Amsterdam, the Netherlands.
Habibul AhsanUniversity of Chicago, Chicago, Illinois.
Kristiina AittomäkiUniversity of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
Laura BagliettoThe University of Melbourne, Melbourne, Victoria, Australia.
Carl BlomquistUniversity of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
Federico CanzianGenomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Kamila CzeneKarolinska Institutet, Stockholm, Sweden.
Isabel Dos-Santos-SilvaDepartment of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom.
A Heather EliassenHarvard T.H. Chan School of Public Health, Boston, Massachusetts. Harvard Medical School, Boston Massachusetts.
Jonine D FigueroaNational Cancer Instititute, Bethesda, Maryland.
Dieter Flesch-JanysUniversity Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Olivia FletcherBreakthrough Research Centre, The Institute of Cancer Research, London, United Kingdom.
Montserrat Garcia-ClosasNational Cancer Instititute, Bethesda, Maryland.
Mia M GaudetEpidemiology Research Program, American Cancer Society, Atlanta, Georgia.
Nichola JohnsonBreakthrough Research Centre, The Institute of Cancer Research, London, United Kingdom.
Per HallKarolinska Institutet, Stockholm, Sweden.
Aditi HazraHarvard Medical School, Boston Massachusetts.
Rebecca HeinDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ) Heidelberg, Germany. Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne, Cologne, Germany.
Albert HofmanDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
John L HopperMelbourne School of Population Health, University of Melbourne, Melbourne, Victoria, Australia.
Astrid IrwantoGenome Institute of Singapore, Singapore.
Mattias JohanssonInternational Agency for Research on Cancer, Lyon, France. Department of Biobank Research, Umea University, Umea, Sweden.
Rudolf KaaksNational Center for Tumor Diseases and German Cancer Research Center (DKFZ), Heidelberg, Germany.
Muhammad G KibriyaUniversity of Chicago, Chicago, Illinois.
Peter LichtnerGerman Research Center for Environmental Health, Neuherberg, Germany.
Jianjun LiuGenome Institute of Singapore, Singapore.
Eiliv LundInstitute of Community Medicine, UiT The Arctic University of Norway, Tromso, Norway.
Enes MakalicMelbourne School of Population Health, University of Melbourne, Melbourne, Victoria, Australia.
Alfons MeindlTechnische Universität München, Munich, Germany.
Bertram Müller-MyhsokMax Planck Institute of Psychiatry, Munich, Germany.
Taru A MuranenUniversity of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
Heli NevanlinnaUniversity of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
Petra H PeetersDepartment of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, the Netherlands.
Julian PetoDepartment of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Ross L PrenticeFred Hutchinson Cancer Research Center, Seattle, Washington.
Nazneen RahmanInstitute of Cancer Research, Sutton, United Kingdom.
Maria Jose SanchezEscuela Andaluza de Salud Publica, Instituto de Investigacion Biosanitaria ibs. GRANADA, Granada, Spain. Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain. CIBER de Epidemiología y Salud Pública CIBERESP, Madrid, Spain.
Daniel F SchmidtMelbourne School of Population Health, University of Melbourne, Melbourne, Victoria, Australia.
Rita K SchmutzlerUniversity of Cologne, Cologne, Germany.
Melissa C SoutheyThe University of Melbourne, Melbourne, Victoria, Australia.
Rulla TamimiHarvard Medical School, Boston Massachusetts.
Ruth C TravisCancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.
Clare TurnbullInstitute of Cancer Research, Sutton, United Kingdom.
Andre G UitterlindenDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands. Department of Internal Medicine, Erasmus MC, Rotterdam, the Netherlands.
Zhaoming WangNational Cancer Instititute, Bethesda, Maryland.
Alice S WhittemoreStanford University, Stanford, California.
Xiaohong R YangNational Cancer Instititute, Bethesda, Maryland.
Wei ZhengVanderbilt University, Nashville, Tennessee.
Daniel D BuchananThe University of Melbourne, Melbourne, Victoria, Australia.
Graham CaseyUniversity of Southern California, Los Angeles, California.
David V ContiUniversity of Southern California, Los Angeles, California.
Christopher K EdlundUniversity of Southern California, Los Angeles, California.
Steven GallingerLunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada.
Robert W HaileStanford University, Stanford, California.
Mark JenkinsThe University of Melbourne, Melbourne, Victoria, Australia.
Loïc Le MarchandEpidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii.
Li LiCase Comprehensive Cancer Center and Mary Ann Swetland Center for Environmental Health, Case Western Reserve University, Cleveland, Ohio.
Noralene M LindorMayo Clinic, Scottsdale, Arizona.
Stephanie L SchmitUniversity of Southern California, Los Angeles, California.
Stephen N ThibodeauMayo Clinic, Rochester, Minnesota.
Michael O WoodsMemorial University of Newfoundland, St. John's, Newfoundland, Canada.
Thorunn RafnardeCODE genetics, Amgen, Reykjavik, Iceland.
Julius GudmundssondeCODE genetics, Amgen, Reykjavik, Iceland.
Simon N StaceydeCODE genetics, Amgen, Reykjavik, Iceland.
Kari StefanssondeCODE genetics, Amgen, Reykjavik, Iceland.
Patrick SulemdeCODE genetics, Amgen, Reykjavik, Iceland.
Y Ann ChenMoffitt Cancer Center, Tampa, Florida.
Jonathan P TyrerUniversity of Cambridge, Cambridge, United Kingdom.
David C ChristianiHarvard T.H. Chan School of Public Health, Boston, Massachusetts.
Yongyue WeiHarvard T.H. Chan School of Public Health, Boston, Massachusetts.
Hongbing ShenNanjing Medical University School of Public Health, Nanjing, China.
Zhibin HuNanjing Medical University School of Public Health, Nanjing, China.
Xiao-Ou ShuVanderbilt University, Nashville, Tennessee.
Kouya ShiraishiDivision of Genome Biology, National Cancer Center Research Institute, Tokyo, Japan.
Atsushi TakahashiLaboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Yohan BosséDepartment of Molecular Medicine, Institut universitaire de cardiologie et de pneumologie de Québec, Laval University, Québec, Canada.
Ma'en ObeidatUniversity of British Columbia Centre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, Canada.
David NickleMerck & Co, Merck Research Laboratories, Seattle, Washington.
Wim TimensUniversity of Groningen, University Medical Center Groningen, GRIAC Research Institute, Groningen, the Netherlands.
Matthew L FreedmanDana-Farber Cancer Institute, Boston, Massachusetts.
Qiyuan LiXiamen University, Xiamen, China.
Daniela SeminaraNational Cancer Instititute, Bethesda, Maryland.
Stephen J ChanockNational Cancer Instititute, Bethesda, Maryland.
Jian GongFred Hutchinson Cancer Research Center, Seattle, Washington.
Ulrike PetersFred Hutchinson Cancer Research Center, Seattle, Washington.
Stephen B GruberUniversity of Southern California, Los Angeles, California.
Christopher I AmosGeisel School of Medicine, Dartmouth College, Hanover, New Hampshire.
Thomas A SellersMoffitt Cancer Center, Tampa, Florida.
Douglas F EastonUniversity of Cambridge, Cambridge, United Kingdom.
David J HunterHarvard T.H. Chan School of Public Health, Boston, Massachusetts.
Christopher A HaimanUniversity of Southern California, Los Angeles, California.
Brian E HendersonUniversity of Southern California, Los Angeles, California.
Rayjean J HungLunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada. rayjean.hung@lunenfeld.ca.
Ovarian Cancer Association Consortium (OCAC)
PRACTICAL Consortium
Hereditary Breast and Ovarian Cancer Research Group Netherlands (HEBON)
Colorectal Transdisciplinary (CORECT) Study
African American Breast Cancer Consortium (AABC) and African Ancestry Prostate Cancer Consortium (AAPC)
University of Southern California · USSvenska Örtmedicinska Institute · SEInstitute of Cancer Research · GBUniversity of Cambridge · GBCentre international de recherche sur le cancer · FRGerman Center for Lung Research · DEHarvard University · USUniversity of Manchester · GB
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MTRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI KENNETH Lynn WRIGHT · 1998 to 2026
$93.5MTranslational Engineering in Cancer (TEC)P30CA023108 · NCI · DARTMOUTH COLLEGE · PI Steven D Leach · 1985 to 2026
$91.3MUniversity of Hawaii Cancer Center CCSGP30CA071789 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI Xin Chen · 1996 to 2026
$56.2MUnderstanding Population Differences in Cancer: The MEC StudyU01CA164973 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI HAIMAN, CHRISTOPHER ALAN, LE MARCHAND, LOIC · 2015 to 2025
$37.4MUse of microfluidic tumor cultures to enable clinical trials of therapies for ovarian cancerP50CA136393 · NCI · MAYO CLINIC ROCHESTER · PI Zhenkun Lou · 2009 to 2026
$37.0MRisk Factors for Breast Cancer in Younger NursesR01CA050385 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI ELIASSEN, A. HEATHER, WILLETT, WALTER C. · 1989 to 2019
$32.3MMolecular pathological epidemiology of colorectal cancerU01CA137088 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI PETERS, ULRIKE · 2009 to 2018
$21.8MDetection of Colorectal Cancer Susceptibility Loci Using Genome-Wide SequencingU01CA164930 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI PETERS, ULRIKE · 2012 to 2015
$12.4MCancer Epidemiology Cohort in Male Health ProfessionalsUM1CA167552 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI WILLETT, WALTER C. · 2012 to 2016
$11.5MColon Cancer Family Registry CohortUM1CA167551 · NCI · STANFORD UNIVERSITY · PI HAILE, ROBERT WILLIAM, JENKINS, MARK A · 2013 to 2017
$11.3MTransdisciplinary Studies of Genetic Variation in Colorectal CancerU19CA148107 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI GRUBER, STEPHEN B · 2010 to 2014
$11.1MCancer Research UK 10119Cancer Research UK 10124Cancer Research UK 15106Cancer Research UK 15116Cancer Research UK 16491Cancer Research UK 16561Cancer Research UK 19170Cancer Research UK A10118Cancer Research UK A10119Cancer Research UK A10124Cancer Research UK A12014Cancer Research UK A16561Cancer Research UK A5660Cancer Research UK A8339Medical Research Council G0700491NCATS NIH HHS UL1 TR001863NCI NIH HHS K05 CA152715NCI NIH HHS P30 CA023108NCI NIH HHS P30 CA071789NCI NIH HHS P30 CA076292NCI NIH HHS P50 CA136393NCI NIH HHS R01 CA050385NCI NIH HHS R01 CA055769NCI NIH HHS R01 CA074386NCI NIH HHS R01 CA092824NCI NIH HHS R01 CA121197NCI NIH HHS R01 CA127219NCI NIH HHS R01 CA133996NCI NIH HHS R35 CA197449NCI NIH HHS U01 CA137088NCI NIH HHS U01 CA164930NCI NIH HHS U01 CA164973NCI NIH HHS U19 CA148065NCI NIH HHS U19 CA148107NCI NIH HHS U19 CA148112NCI NIH HHS U19 CA148127NCI NIH HHS U19 CA148537NCI NIH HHS UM1 CA167551NCI NIH HHS UM1 CA167552NIH HHS S10 OD020069World Health Organization 001
Abstract
Identifying genetic variants with pleiotropic associations can uncover common pathways influencing multiple cancers. We took a two-stage approach to conduct genome-wide association studies for lung, ovary, breast, prostate, and colorectal cancer from the GAME-ON/GECCO Network (61,851 cases, 61,820 controls) to identify pleiotropic loci. Findings were replicated in independent association studies (55,789 cases, 330,490 controls). We identified a novel pleiotropic association at 1q22 involving breast and lung squamous cell carcinoma, with eQTL analysis showing an association with ADAM15/THBS3 gene expression in lung. We also identified a known breast cancer locus CASP8/ALS2CR12 associated with prostate cancer, a known cancer locus at CDKN2B-AS1 with different variants associated with lung adenocarcinoma and prostate cancer, and confirmed the associations of a breast BRCA2 locus with lung and serous ovarian cancer. This is the largest study to date examining pleiotropy across multiple cancer-associated loci, identifying common mechanisms of cancer development and progression. Cancer Res; 76(17); 5103-14. ©2016 AACR.
Indexed as
Breast NeoplasmsColorectal NeoplasmsFemaleGenome-Wide Association StudyGenotypeHumansLung NeoplasmsMaleOvarian NeoplasmsProstatic Neoplasms
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